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The Novel Antigenic Epitopes of African Swine Fever Virus Inner Membrane p54 Protein Revealed by Monoclonal Antibodies [PDF]

Animals
African swine fever (ASF) is caused by the African swine fever virus (ASFV); infection in domestic pigs and wild boars leads to a highly contagious, hemorrhagic disease.
Jianfa Bai, Wanglong Zheng, Nanhua Chen
exaly   +6 more sources

Development of a cost-effective serodiagnosis for African swine fever using solubility-enhanced recombinant p54, p30, and p72 [PDF]

Veterinary World
Background and Aim: The rapid spread of African swine fever (ASF) in Indonesia and other Asian countries has devastated domestic and wild pig populations.
Simson Tarigan, Sumarningsih Sumarningsih, Atik Ratnawati, Muharam Saepulloh, Wasito Wasito, Indrawati Sendow, Harimurti Nuradji, Ni Luh Putu Indi Dharmayanti   +7 more
doaj   +5 more sources

Identification of a Conserved Linear Epitope on the p54 Protein of African Swine Fever Virus [PDF]

Viruses
African swine fever virus (ASFV) is a highly virulent pathogen that causes nearly 100% mortality in acute infections and poses persistent risks. Effective containment of ASFV outbreaks requires rapid and reliable diagnostic tools.
Kuijing He, Yue Wu, Zhipeng Su, Yue Zeng, Guishan Ye, Qi Wu, Long Li, Anding Zhang   +7 more
doaj   +4 more sources

Identification of a Linear B Cell Epitope on p54 of African Swine Fever Virus Using Nanobodies as a Novel Tool

Microbiology Spectrum, 2023
African swine fever (ASF) has received great attention from the swine industry due to the pandemic and the lack of vaccines or effective treatments. In the present study, 13 African swine fever virus (ASFV) p54-specific nanobodies (Nbs) were successfully
Huijun Zhao, Gaijie Wang, Haoxin Dong, Shuya Wu, Yongkun Du, Bo Wan, Pengchao Ji, Yanan Wu, Dawei Jiang, Guoqing Zhuang, Hong Duan, Gaiping Zhang, Angke Zhang   +12 more
doaj   +3 more sources

Fusion with immunoglobulin Fc fragment enhances the immunogenicity of the African swine fever virus p30/p54 fusion protein [PDF]

Applied Microbiology and Biotechnology
African swine fever (ASF) is a significant threat to the global pig breeding industry, making the development of a vaccine extremely urgent. In this study, the key antigenic proteins p30 and p54 of African swine fever virus (ASFV) were fused with the Fc ...
Haimi Dang, Yi Ru, Guoqiang Wu, Rongzeng Hao, Jie Xu, Yajun Li, Dongmei Zhao, Chenghui Jiang, Shengnan Han, Xinyu Hu, Xiuping Wu, Yang Yang, Haixue Zheng   +12 more
doaj   +3 more sources

Novel Linear B Cell Epitopes of ASFV p54: Screening and Fine-Scale Mapping [PDF]

Microorganisms
African swine fever (ASF) is an acute, febrile, and lethal pig disease induced by the African swine fever virus (ASFV). In the absence of an effective vaccine, early diagnosis is essential for the prevention and control of ASF disease. The p54 protein is
Haili Wang, Wenying Yan, Xiao Liu, Yanwei Wang, Shulei Li, Linyi Bai, Xiaomin Li, Yaxin Guo, Aiping Wang   +8 more
doaj   +3 more sources

A Novel Linear B-Cell Epitope on the P54 Protein of African Swine Fever Virus Identified Using Monoclonal Antibodies

Viruses, 2023
The African swine fever virus (ASFV) is a highly infectious viral pathogen that presents a major threat to the global pig industry. No effective vaccine is available for the virus.
Shichong Han, Yongkun Du
exaly   +4 more sources

Characterization of Anti-p54 Monoclonal Antibodies and Their Potential Use for African Swine Fever Virus Diagnosis

Pathogens, 2021
African swine fever (ASF) is a highly lethal hemorrhagic viral disease of domestic pigs caused by African swine fever virus (ASFV). Although a good advance has been made to understand the virus, a safe and effective vaccine against ASFV is still lacking ...
Dongming Zhao, Zhigao Bu, Weldu Tesfagaber   +2 more
exaly   +4 more sources

Preparation of Monoclonal Antibodies Against the Viral p54 Protein and a Blocking ELISA for Detection of the Antibody Against African Swine Fever Virus

Viruses, 2022
African swine fever virus (ASFV) causes a highly contagious viral disease in domestic and wild pigs, leading to serious economic losses. As there are no vaccines or drugs available, early accurate diagnosis and eradiation of infected animals are the most
Haixue Zheng, Lujie Zhang
exaly   +4 more sources

Indirect ELISA Using Multi–Antigenic Dominants of p30, p54 and p72 Recombinant Proteins to Detect Antibodies against African Swine Fever Virus in Pigs

Viruses, 2022
African swine fever (ASF) caused by ASF virus (ASFV) is a fatal disease in pigs and results in great economic losses. Due to the lack of available vaccines and treatments, serological diagnosis of ASF plays a key role in the surveillance program, but due
Dexin Li, Qin Zhang, Yutian Liu, Miaoli Wang, Lei Zhang, Liyuan Han, Xuefei Chu, Guofei Ding, Yingchao Li, Yanmeng Hou, Sidang Liu, Zhiliang Wang, Yihong Xiao   +12 more
doaj   +2 more sources