Loss of p62 Binding Allows TIF-IA Accumulation in Senescence, Which Promotes Phenotypic Changes to Nucleoli and the Senescence Associated Secretory Phenotype. [PDF]
Thoms HC +17 more
europepmc +1 more source
Traumatic brain injury and autophagy: a pilot study about the immunohistochemical expression of LC3B, Beclin 1, p62, and LAMP2A in human autoptic samples [PDF]
Tommaso Livieri +8 more
openalex +1 more source
Tui Na Acupressure Modulates Treg Immunosuppression via FoxP3/mTORC1 Signalling in ALS Mice
The proposed mechanism by which Tui Na acupressure improves motor and cognitive dysfunction in ALS mice by activating the FoxP3/mTORC1 pathway. ABSTRACT Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease driven by neuroinflammation, where regulatory T cell (Treg) dysfunction exacerbates immune imbalance.
Jie Han +7 more
wiley +1 more source
Comprehensive pan-cancer analysis of p62 reveals its contribution to shaping tumor microenvironment and anti-tumor immunity. [PDF]
Nayeri Z +6 more
europepmc +1 more source
Consumer Perspectives on PICU Safety and Quality
ABSTRACT This study aimed to examine consumer perceptions and priorities for safety and quality in paediatric intensive care units (PICUs) to inform safety measurement and quality improvement efforts. We conducted a cross‐sectional, co‐designed survey distributed to PICU parents/caregivers across Australia and New Zealand.
Karina R. Charles +10 more
wiley +1 more source
Low-dose Simvastatin protects pancreatic cancer cells by promoting mitochondrial autophagy through TFEB. [PDF]
Wang Z +16 more
europepmc +1 more source
NSUN2 mediated-aberrant 5-methylcytosine methylation regulates autophagy-related ferroptosis in oral squamous cell carcinoma progression. [PDF]
Lu Y +11 more
europepmc +1 more source
The Phospholamban (PLN) R9C mutation reduces SERCA2a binding, increasing calcium recycling and baseline contractility. However, the excess of free PLN promotes pentamer formation, limiting phosphorylation and blunting β‐adrenergic signaling. Under cardiac stress, enhanced functional demands overwhelm proteostasis in PLN R9C cells, leading to misfolded ...
Qi Yu +10 more
wiley +1 more source
Acacetin Attenuates Lysophosphatidylcholine-Induced Vascular Smooth Muscle Cell Injury via Sirt1-Nrf2/p62 Signaling Axis. [PDF]
Li YD +7 more
europepmc +1 more source
Alteration of p62/SQSTM1 Expression Is Uncommon in Gastrointestinal and Prostate Cancer Tissues
Eun Mi Je, Nam Jin Yoo, Sung Sik Lee
openalex +1 more source

