Results 111 to 120 of about 14,891 (243)
Functional Diversity of Neurotrophin Actions on the Oculomotor System [PDF]
, 2016 Neurotrophins play a principal role in neuronal survival and differentiation during development, but also in the maintenance of appropriate adult neuronal circuits and phenotypes.
Benítez Temiño, Beatriz +5 more
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Frontiers in Molecular Neuroscience, 2018 The p75 neurotrophin receptor (p75NTR), also known as low-affinity nerve growth factor, belongs to the tumor necrosis factor family of receptors. p75NTR is widely expressed in the nervous system during the development, as well as, in the neural crest ...
Sabine Wislet +3 more
doaj +1 more source
The FEBS Journal, Volume 292, Issue 23, Page 6163-6181, December 2025.Conserved context‐dependent cis‐regulatory elements act as a major reservoir of disease‐associated polymorphisms in the human genome and are also affected by epigenetic change. This ‘state‐of‐the‐art’ review explores the latest developments in studying these enigmatic elements and how the effects of disease‐associated polymorphisms and environmentally ...
Andrew McEwan +5 more
wiley +1 more source
Nerve growth factor improves the muscle regeneration capacity of muscle stem cells in dystrophic muscle. [PDF]
, 2006 Researchers have attempted to use gene- and cell-based therapies to restore dystrophin and alleviate the muscle weakness that results from Duchenne muscular dystrophy (DMD). Our research group has isolated populations of muscle-derived stem cells (MDSCs)
ACOSTA C.G. +8 more
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Human immunomodulatory ligand B7-1 mediates synaptic remodeling via the p75 neurotrophin receptor
The Journal of Clinical Investigation, 2022 Cell surface receptors, ligands, and adhesion molecules underlie development, circuit formation, and synaptic function of the central nervous system and represent important therapeutic targets for many neuropathologies.
Nicholas C. Morano +14 more
doaj +1 more source
p75NTR receptor – role in cell growth and apoptosis
Postępy Higieny i Medycyny Doświadczalnej, 2012 The neurotrophins play an important role in the development of the nervous system. These trophic factors affect the cells through the neurotrophin receptors Trk and p75NTR. Trk (tyrosine kinase receptor) mediated signaling promotes survival and growth, while p75NTR-mediated signaling promotes cell death.
openaire +2 more sources
p75NTR prevents the onset of cerebellar granule cell migration via RhoA activation
, 2022 Juan Pablo Zanin, Wilma Friedman
openalex +1 more source
An antisense-long-noncoding-RNA modulates p75NTR expression levels during neuronal polarization
iScienceSummary: Proper polarization of newly generated neurons is a critical process for neural network formation and brain development. The pan-neurotrophin p75NTR receptor plays a key role in this process localizing asymmetrically in one of the ...
Veronica De Paolis +9 more
doaj +1 more source
The p75 Neurotrophin Receptor Facilitates TrkB Signaling and Function in Rat Hippocampal Neurons
Frontiers in Cellular Neuroscience, 2019 Neurotrophins activate Trk receptor signaling to support neuronal survival and many aspects of neuronal function. Early studies demonstrated that TrkA formed a complex with the p75 neurotrophin receptor (p75NTR), which increased the affinity and ...
Juan P. Zanin +3 more
doaj +1 more source
Cartilage stem/progenitor cells are activated in osteoarthritis via interleukin-1β/nerve growth factor signaling [PDF]
, 2015 Introduction: Interleukin-1β (IL-1β) and nerve growth factor (NGF) are key regulators in the pathogenesis of inflammatory arthritis; specifically, IL-1β is involved in tissue degeneration and NGF is involved in joint pain.
Hu, C +6 more
core +3 more sources