Results 31 to 40 of about 14,891 (243)

Nerve growth factor, brain-derived neurotrophic factor, and the chronobiology of mood: a new insight into the "neurotrophic hypothesis" [PDF]

, 2015
The light information pathways and their relationship with the body rhythms have generated a new insight into the neurobiology and the neurobehavioral sciences, as well as into the clinical approaches to human diseases associated with disruption of ...
IANNITELLI, ANGELA, Quartini, Adele, Tirassa, Paola   +2 more
core   +2 more sources

Increased expression and activity of p75NTR are crucial events in azacitidine-induced cell death in prostate cancer [PDF]

, 2016
The high affinity nerve growth factor (NGF) NGF receptor, p75NTR, is a member of the tumor necrosis factor (TNF) receptor superfamily that shares a conserved intracellular death domain capable of inducing apoptosis and suppressing growth in prostate ...
Biordi, Leda, Colapietro, Alessandro, Festuccia, Claudio, Ficorella, Corrado, Gravina, Giovanni Luca, Jitariuc, Ana, Mancini, Andrea, Marampon, Francesco, Sanità, Patrizia, Scarsella, Luca   +9 more
core   +2 more sources

AraC interacts with p75NTR transmembrane domain to induce cell death of mature neurons

Cell Death and Disease, 2023
Cytosine arabinoside (AraC) is one of the main therapeutic treatments for several types of cancer, including acute myeloid leukaemia. However, after a high-dose AraC chemotherapy regime, patients develop severe neurotoxicity and cell death in the central
Vanessa Lopes-Rodrigues, Pia Boxy, Eunice Sim, Dong Ik Park, Michael Habeck, Josep Carbonell, Annika Andersson, Diana Fernández-Suárez, Poul Nissen, Anders Nykjær, Lilian Kisiswa   +10 more
doaj   +1 more source

p75 neurotrophin receptor mediates apoptosis in transit-amplifying cells and its overexpression restores cell death in psoriatic keratinocytes. [PDF]

, 2011
p75 neurotrophin receptor (p75NTR) belongs to the TNF-receptor superfamily and signals apoptosis in many cell settings. In human epidermis, p75NTR is mostly confined to the transit-amplifying (TA) sub-population of basal keratinocytes.
DALLAGLIO, Katiuscia, LOTTI, Roberta, M. C. Panza, MARCONI, Alessandra, P. Atzei, PALAZZO, ELISABETTA, PINCELLI, Carlo, R. Tiberio, TRUZZI, Francesca, VASCHIERI, Cristina   +9 more
core   +1 more source

Nogo receptor antagonizes p75NTR-dependent motor neuron death [PDF]

Proceedings of the National Academy of Sciences, 2008
The Nogo-66 receptor (NgR) plays a critical role in restricting axon regeneration in the central nervous system. This inhibitory action is in part mediated by a neuronal receptor complex containing p75NTR, a multifunctional receptor also well known to trigger cell death upon binding to neurotrophins such as NGF.
Dupuis, L, Pehar, M, Cassina, P, Rene, F, Castellanos, R, Rouaux, C, Gandelman, M, Dimou, L, Schwab, M E, Loeffler, J P, Barbeito, L, Gonzalez de Aguilar, J L   +11 more
openaire   +3 more sources

p75NTR as a Molecular Memory Switch [PDF]

, 2019
In recent years, many molecular and environmental factors have been studied to understand how synaptic plasticity is modulated. Sleep, as an evolutionary conserved biological function, has shown to be a critical player for the consolidation and filtering of synaptic circuitry underlying memory traces.
Shen Ning, Mehdi Jorfi
openalex   +4 more sources

Expression and clinical significance of p75NTR in esophageal squamous cell carcinoma

Mathematical Biosciences and Engineering, 2019
Objectives To analyze the expression and clinical significance of p75NTR in esophageal squamous cell carcinoma. Methods Sixty patients with esophageal squamous cell carcinoma who underwent surgical resection in our hospital between January 2017 and ...
Dijian Shen, Youhua Jiang, Kaiyi Tao
doaj   +1 more source

Isolation and characterization of neural crest-like progenitor cells in human umbilical cord blood

Regenerative Therapy, 2020
Introduction: Neural crest (NC)-like stem/progenitor cells provide an attractive cell source for regenerative medicine because of their multipotent property and ease of isolation from adult tissue.
Zena Al-Bakri, Mika Ishige-Wada, Noboru Fukuda, Chikako Yoshida-Noro, Narihito Nagoshi, Hideyuki Okano, Hideo Mugishima, Taro Matsumoto   +7 more
doaj   +1 more source

Regulation of the p75 neurotrophin receptor attenuates neuroinflammation and stimulates hippocampal neurogenesis in experimental Streptococcus pneumoniae meningitis

Journal of Neuroinflammation, 2021
Background Streptococcus pneumoniae meningitis is a destructive central nervous system (CNS) infection with acute and long-term neurological disorders. Previous studies suggest that p75NTR signaling influences cell survival, apoptosis, and proliferation ...
Dandan Zhang, Shengnan Zhao, Zhijie Zhang, Danfeng Xu, Di Lian, Jing Wu, Dake He, Kun Sun, Ling Li   +8 more
doaj   +1 more source

p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks. [PDF]

, 2013
The p75 neurotrophin receptor (p75(NTR)) is a member of the tumor necrosis factor receptor superfamily with a widespread pattern of expression in tissues such as the brain, liver, lung, and muscle.
Akassoglou, Katerina, Baeza-Raja, Bernat, Eckel-Mahan, Kristin, Ptácek, Louis J, Sassone-Corsi, Paolo, Tsigelny, Igor F, Vagena, Eirini, Zhang, Luoying   +7 more
core   +2 more sources