Results 41 to 50 of about 14,891 (243)

The role and potential mechanism of p75NTR in mineralization via in vivo p75NTR knockout mice and in vitro ectomesenchymal stem cells [PDF]

Cell Proliferation, 2020
AbstractObjectiveThe aim of this study is to investigate the role and potential mechanism of p75NTR in mineralization in vivo using p75NTR‐knockout mice and in vitro using ectomesenchymal stem cells (EMSCs).Materials and methodsFemur bone mass and daily incisor mineralization speed were assessed in an in vivo p75NTR‐knockout mouse model.
Manzhu Zhao, Yingying Wang, Gang Li, Jun Li, Kun Yang, Chang Liu, Xiujie Wen, Jinlin Song   +7 more
openaire   +2 more sources

The pharmacological perturbation of brain zinc impairs BDNF-related signaling and the cognitive performances of young mice. [PDF]

, 2018
Zinc (Zn2+) is a pleiotropic modulator of the neuronal and brain activity. The disruption of intraneuronal Zn2+ levels triggers neurotoxic processes and affects neuronal functioning.
Bomba, Manuela, Castelli, Vanessa, Castelli, Vanessa, Cimini, Annamaria, d'Aurora, Marco, Delli Pizzi, Stefano, Frazzini, Valerio, Gatta, Valentina, Granzotto, Alberto, Iorio, Mariangela, Massetti, Noemi, Mosca, Alessandra, Punzi, Miriam, Sensi, Stefano L   +13 more
core   +3 more sources

Genetic Dissection of Neurotrophin Signaling through the p75 Neurotrophin Receptor

Cell Reports, 2012
Structural determinants underlying signaling specificity in the tumor necrosis factor receptor superfamily (TNFRSF) are poorly characterized, and it is unclear whether different signaling outputs can be genetically dissociated.
Ioannis Charalampopoulos, Annalisa Vicario, Iosif Pediaditakis, Achille Gravanis, Anastasia Simi, Carlos F. Ibáñez   +5 more
doaj   +1 more source

Developmental axon pruning mediated by BDNF-p75NTR–dependent axon degeneration [PDF]

, 2008
The mechanisms that regulate the pruning of mammalian axons are just now being elucidated. Here, we describe a mechanism by which, during developmental sympathetic axon competition, winning axons secrete brain-derived neurotrophic factor (BDNF) in an ...
A Bagri, AP Hibbert, AR Vaillant, Bianca M Kramer, BL MacInnis, C Mytilineou, CE Hill, CG Causing, D Purves, David R Kaplan, DL Bishop, DR Kaplan, Elizabeth J Hong, FD Miller, FD Miller, Freda D Miller, G Yiu, GJ Michael, H Nakamura, IJ MacPhee, J Kohn, JK Atwal, JK Atwal, JM Korhonen, JM Lawrence, Karun K Singh, Katya J Park, KF Lee, KK Singh, L Cao, L Luo, M Majdan, M Majdan, M Vidovic, M Vidovic, Michael E Greenberg, N Plachta, NK Dhanoa, Q Zhai, RB Campenot, RB Campenot, RB Campenot, RE Coggeshall, RS Aloyz, SX Bamji, TT Yeo, WB Gan, WG Chen, WJ Friedman, X Tao, Y Ma   +50 more
core   +1 more source

The p75NTR neurotrophin receptor is required to organize the mature neuromuscular synapse by regulating synaptic vesicle availability

Acta Neuropathologica Communications, 2019
The coordinated movement of organisms relies on efficient nerve-muscle communication at the neuromuscular junction. After peripheral nerve injury or neurodegeneration, motor neurons and Schwann cells increase the expression of the p75NTR pan-neurotrophin
Viviana Pérez, Francisca Bermedo-Garcia, Diego Zelada, Felipe A. Court, Miguel Ángel Pérez, Marco Fuenzalida, Johanna Ábrigo, Claudio Cabello-Verrugio, Guillermo Moya-Alvarado, Juan Carlos Tapia, Vicente Valenzuela, Claudio Hetz, Francisca C. Bronfman, Juan Pablo Henríquez   +13 more
doaj   +1 more source

NADE, a p75NTR-associated Cell Death Executor, Is Involved in Signal Transduction Mediated by the Common Neurotrophin Receptor p75NTR [PDF]

Journal of Biological Chemistry, 2000
The low affinity neurotrophin receptor p75NTR can mediate cell survival as well as cell death of neural cells by NGF and other neurotrophins. To elucidate p75NTR-mediated signal transduction, we screened p75NTR-associated proteins by a yeast two-hybrid system.
J, Mukai, T, Hachiya, S, Shoji-Hoshino, M T, Kimura, D, Nadano, P, Suvanto, T, Hanaoka, Y, Li, S, Irie, L A, Greene, T A, Sato   +10 more
openaire   +2 more sources

p75 Neurotrophin Receptor Suppresses the Proliferation of Human Gastric Cancer Cells

Neoplasia: An International Journal for Oncology Research, 2007
Identifying an effective therapeutic target is pivotal in the treatment of gastric cancer. In this study, we investigated the expression of p75 neurotrophin receptor (p75NTR) in gastric cancer and the impact of its alteration on tumor growth.
Haifeng Jin, Yanglin Pan, Lina Zhao, Huihong Zhai, Xiaohua Li, Li Sun, Lijie He, Yu Chen, Liu Hong, Yulei Du, Daiming Fan   +10 more
doaj   +1 more source

p75NTR: an enhancer of fenretinide toxicity in neuroblastoma [PDF]

Cancer Chemotherapy and Pharmacology, 2013
Neuroblastoma is a common, frequently fatal, neural crest tumor of childhood. Chemotherapy-resistant neuroblastoma cells typically have Schwann cell-like ("S-type") morphology and express the p75 neurotrophin receptor (p75NTR). p75NTR has been previously shown to modulate the redox state of neural crest tumor cells.
Veena, Ganeshan, John, Ashton, Nina F, Schor   +2 more
openaire   +2 more sources

Trophic and neurotrophic factors in human pituitary adenomas (Review) [PDF]

, 2017
The pituitary gland is an organ that functionally connects the hypothalamus with the peripheral organs. The pituitary gland is an important regulator of body homeostasis during development, stress, and other processes.
Agostinelli, Enzo, Altissimi, Giancarlo, Artico, Marco, Bardella, Lia, Giangaspero, Felice, Minni, Antonio, Parnigotto, Pier Paolo, Pastore, Francesco Saverio, Spoletini, Marialuisa, Taurone, Samanta, Tombolini, Mario, Wierzbicki, Venceslao   +11 more
core   +1 more source

The p75 neurotrophin receptor localization in blood-CSF barrier: expression in choroid plexus epithelium

BMC Neuroscience, 2011
Background The presence of neurotrophins and their receptors Trk family has been reported in the choroid plexus. High levels of Nerve Growth Factor (NGF), Neurotrophin-4 (NT-4) and TrkB receptor were detected, while nothing was know about p75 ...
Spuch Carlos, Carro Eva
doaj   +1 more source