Results 41 to 50 of about 10,177 (244)
p75NTR as a Molecular Memory Switch [PDF]
, 2019 In recent years, many molecular and environmental factors have been studied to understand how synaptic plasticity is modulated. Sleep, as an evolutionary conserved biological function, has shown to be a critical player for the consolidation and filtering of synaptic circuitry underlying memory traces.
Ning, Shen, Jorfi, Mehdi
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Oxidative Medicine and Cellular Longevity, 2020 Oxidative stress and apoptosis play a key role in the pathogenesis of sepsis-associated acute kidney injury (AKI). Dexmedetomidine (DEX) may present renal protective effects in sepsis. Therefore, we studied antioxidant effects and the mechanism of DEX in
Zhe Wang +6 more
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Reduced anxiety-like behavior and altered hippocampal morphology in female p75NTR exon IV-/- mice.
Frontiers in Behavioral Neuroscience, 2016 The presence of the neurotrophin receptor p75NTR in adult basal forebrain cholinergic neurons, precursor cells in the subventricular cell layer and the subgranular cell layer of the hippocampus has been linked to alterations in learning as well as ...
Zoe ePuschban +4 more
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Expression and clinical significance of p75NTR in esophageal squamous cell carcinoma
Mathematical Biosciences and Engineering, 2019 Objectives To analyze the expression and clinical significance of p75NTR in esophageal squamous cell carcinoma. Methods Sixty patients with esophageal squamous cell carcinoma who underwent surgical resection in our hospital between January 2017 and ...
Dijian Shen, Youhua Jiang, Kaiyi Tao
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NADE, a p75NTR-associated Cell Death Executor, Is Involved in Signal Transduction Mediated by the Common Neurotrophin Receptor p75NTR [PDF]
Journal of Biological Chemistry, 2000 The low affinity neurotrophin receptor p75NTR can mediate cell survival as well as cell death of neural cells by NGF and other neurotrophins. To elucidate p75NTR-mediated signal transduction, we screened p75NTR-associated proteins by a yeast two-hybrid system.
Shisako Shoji-Hoshino +10 more
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AraC interacts with p75NTR transmembrane domain to induce cell death of mature neurons
Cell Death and Disease, 2023 Cytosine arabinoside (AraC) is one of the main therapeutic treatments for several types of cancer, including acute myeloid leukaemia. However, after a high-dose AraC chemotherapy regime, patients develop severe neurotoxicity and cell death in the central
Vanessa Lopes-Rodrigues +10 more
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Genetic Dissection of Neurotrophin Signaling through the p75 Neurotrophin Receptor
Cell Reports, 2012 Structural determinants underlying signaling specificity in the tumor necrosis factor receptor superfamily (TNFRSF) are poorly characterized, and it is unclear whether different signaling outputs can be genetically dissociated.
Ioannis Charalampopoulos +5 more
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Journal of Neuroinflammation, 2021 Background Streptococcus pneumoniae meningitis is a destructive central nervous system (CNS) infection with acute and long-term neurological disorders. Previous studies suggest that p75NTR signaling influences cell survival, apoptosis, and proliferation ...
Dandan Zhang +8 more
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p75 Neurotrophin Receptor Suppresses the Proliferation of Human Gastric Cancer Cells
Neoplasia: An International Journal for Oncology Research, 2007 Identifying an effective therapeutic target is pivotal in the treatment of gastric cancer. In this study, we investigated the expression of p75 neurotrophin receptor (p75NTR) in gastric cancer and the impact of its alteration on tumor growth.
Haifeng Jin +10 more
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p75NTR Is Positively Promiscuous [PDF]
Neuron, 2004 Although identified almost 20 years ago, the precise physiological role of the p75 neurotrophin receptor (p75NTR) has remained elusive. Recent studies have revealed that p75NTR is a component of three distinct receptor platforms that bind different ligands and that, under differing circumstances, facilitate cell survival, cell death, or growth ...
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