Results 71 to 80 of about 10,177 (244)

Biochemical and functional interactions between the neurotrophin receptors trk and p75NTR [PDF]

The EMBO Journal, 1999
Neurotrophins bind to two structurally unrelated receptors, the trk tyrosine kinases and the neurotrophin receptor p75(NTR). Ligand activation of these two types of receptor can lead to opposite actions, in particular the prevention or activation of programmed cell death.
Bibel, M., Hoppe, E., Barde, Y. A.
openaire   +3 more sources

Electrical stimulation of injured nerves promotes recovery in animals and humans

The Journal of Physiology, EarlyView.
Abstract figure legend Poor functional recovery after surgical repair is frequently disappointing. In an experimental rat model, we found that by isolating the effects of prolonged motoneurone isolation from targets (prolonged axotomy), reduced regenerative capacity and prolonged isograft denervation, and muscle denervation each reduced regeneration ...
Tessa Gordon
wiley   +1 more source

Fast-diffusing p75NTR monomers support apoptosis and growth cone collapse by neurotrophin ligands

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Neurotrophins (NTs) are homodimeric growth factors displaying fundamental roles in the nervous system. Their activity stems from binding and activation of 3 different receptor types in nervous cell membranes. The p75 NT receptor (p75NTR) was
L. Marchetti, Fulvio Bonsignore, F. Gobbo, Rosy Amodeo, M. Calvello, A. Jacob, G. Signore, Chiara Schirripa Spagnolo, David Porciani, M. Mainardi, F. Beltram, S. Luin, A. Cattaneo   +12 more
semanticscholar   +1 more source

Mouse skin fibroblasts with mesenchymal stem cell marker p75 neurotrophin receptor proliferate in response to prolyl-hydroxyproline

Journal of Functional Foods, 2020
Prolyl-hydroxyproline (Pro-Hyp) levels increase in human blood on ingesting collagen hydrolysate and trigger proliferation of primary cultured fibroblasts attached on collagen.
Tomoko T. Asai, Kazunobu Yoshikawa, Kazuhiro Sawada, Kazuna Fukamizu, Yoh-ichi Koyama, Yasutaka Shigemura, Shiro Jimi, Kenji Sato   +7 more
doaj  

Rabies Virus Hijacks and accelerates the p75NTR retrograde axonal transport machinery. [PDF]

PLoS Pathogens, 2014
Rabies virus (RABV) is a neurotropic virus that depends on long distance axonal transport in order to reach the central nervous system (CNS). The strategy RABV uses to hijack the cellular transport machinery is still not clear.
Shani Gluska, Eitan Erez Zahavi, Michael Chein, Tal Gradus, Anja Bauer, Stefan Finke, Eran Perlson   +6 more
doaj   +1 more source

Immune activation of the p75 neurotrophin receptor: implications in neuroinflammation

Frontiers in Molecular Neuroscience, 2023
Despite structural similarity with other tumor necrosis factor receptor superfamily (TNFRSF) members, the p75 neurotrophin receptor (p75NTR, TNFR16) mediates pleiotropic biological functions not shared with other TNFRs.
Victor Danelon, Sarah C. Garret-Thomson, Steven C. Almo, Francis S. Lee, Barbara L. Hempstead   +4 more
doaj   +1 more source

Arterial–venous differences of brain‐derived neurotrophic factor isoforms across the brain and muscle after exercise at different intensities

The Journal of Physiology, EarlyView.
Abstract figure legend Exercise‐induced increases in forearm venous plasma and serum brain‐derived neurotrophic factor (BDNF) are often assumed to be indicative of release from the brain. Sixteen healthy and physically fit adults (20–40 years old) were recruited to investigate whether exercise‐induced changes in forearm venous mature BDNF (mBDNF) and ...
Olga Tarassova, Yiwen Jiang, Helena Wallin, Mats Jensen‐Urstad, Nikola Drca, Julia Röja, Marjan Pontén, Abram Katz, Jonna Nilsson, Maria M. Ekblom, Marcus Moberg   +10 more
wiley   +1 more source

Exploring of Antidepressant Components and Mechanisms of Zhizichi Decoction: Integration of Serum Pharmacochemistry, Network Pharmacology and Anti‐inflammatory Analysis Verification

Analytical Science Advances, Volume 6, Issue 1, June 2025.
ABSTRACT Using LC–MS to screen and analyse the characteristics of components and biological systems is a new approach to study the pharmacological substance basis of traditional Chinese medicine, which has strong novelty in analytical science. This study analyses the antidepressant material basis of Zhizichi decoction through the integration strategy ...
Chuan Chai, Bo Jin, Jinghan Bi, Yuhan Cui, Xiaobing Cui, Chenxiao Shan, Sheng Yu, Hongmei Wen   +7 more
wiley   +1 more source

Ablation of p75NTR signaling strengthens gamma–theta rhythm interaction and counteracts Aβ-induced degradation of neuronal dynamics in mouse hippocampus in vitro

Translational Psychiatry, 2021
Gamma and theta brain rhythms play important roles in cognition and their interaction can affect gamma oscillation features. Hippocampal theta oscillations depend on cholinergic and GABAergic input from the medial septum-diagonal band of Broca.
Yuniesky Andrade-Talavera, Hugo Balleza-Tapia, Pablo Dolz-Gaitón, Gefei Chen, Jan Johansson, André Fisahn   +5 more
doaj   +1 more source

NRAGE, a p75NTR adaptor protein, is required for developmental apoptosis in vivo [PDF]

Cell Death & Differentiation, 2008
NRAGE (also known as Maged1, Dlxin) is a member of the MAGE gene family that may play a role in the neuronal apoptosis that is regulated by the p75 neurotrophin receptor (p75NTR). To test this hypothesis in vivo, we generated NRAGE knockout mice and found that NRAGE deletion caused a defect in developmental apoptosis of sympathetic neurons of the ...
H N T Nguyen, David Andrieu, M Leclercq-Smekens, Françoise Muscatelli, O De Backer, O De Backer, Philip A. Barker, Mariève Bertrand, Mariève Bertrand, Mariève Bertrand, Bruce D. Carter, Rajappa S. Kenchappa   +11 more
openaire   +7 more sources