Results 71 to 80 of about 14,891 (243)
Neurotrophin receptor p75 mediates amyloid β-induced tau pathology
Neurobiology of Disease, 2019 Neurofibrillary tangles of hyperphosphorylated tau protein (p-tau) are a key pathological feature of Alzheimer's disease (AD). Tau phosphorylation is suggested to be secondary to amyloid-beta (Aβ) accumulation.
Lin-Lin Shen +14 more
doaj +1 more source
ASN Neuro, 2020 The p75 neurotrophin receptor (p75NTR) can regulate multiple cellular functions including proliferation, survival, and apoptotic cell death. The p75NTR is widely expressed in the developing brain and is downregulated as the nervous system matures, with ...
Laura E. Montroull +8 more
doaj +1 more source
p75NTR Promotes Circadian‐Driven Mineralization During Tooth Development via CK2/PER2 Pathway
Cell Proliferation, EarlyView.The diagram illustrates how the circadian rhythm regulates the p75NTR‐CK2‐PER2 axis, driving rhythmic biomineralisation during tooth development. ABSTRACT Circadian rhythm is an essential biological process that synchronises physiological activities with environmental light/dark cycles.
Manzhu Zhao +8 more
wiley +1 more source
Immune activation of the p75 neurotrophin receptor: implications in neuroinflammation
Frontiers in Molecular Neuroscience, 2023 Despite structural similarity with other tumor necrosis factor receptor superfamily (TNFRSF) members, the p75 neurotrophin receptor (p75NTR, TNFR16) mediates pleiotropic biological functions not shared with other TNFRs.
Victor Danelon +4 more
doaj +1 more source
Pro-neurotrophins secreted from retinal ganglion cell axons are necessary for ephrinA-p75NTR-mediated axon guidance [PDF]
, 2010 Background: Retinotectal map formation develops via topographically specific guidance and branching of retinal axons in their target area. This process is controlled, in part, by reverse signalling of ephrinAs expressed on retinal axons.
Corinna Wentzel +4 more
core +2 more sources
Nitrate Prevents Sjögren's Disease by Modulating T Helper Cells via NF‐κB Pathway Suppression
Oral Diseases, EarlyView.ABSTRACT Objective Sjögren's disease (SjD) is a chronic autoimmune disease characterized by abnormal T helper (Th) cell distribution in the salivary glands (SGs). Although nitrate can regulate immune responses and preserve SGs function, its preventive effects on SjD remain unexplored.
Conglin Du +8 more
wiley +1 more source
p75NTR in Huntington's disease: beyond the basal ganglia
Oncotarget, 2015 Huntington’s disease (HD) is a fatal neurodegenerative disorder with a characteristic phenotype including chorea and dystonia, uncoordinated fine movements, cognitive decline and psychiatric disturbances. Even though the clinical diagnosis of HD relies on the manifestation of motor abnormalities, the associated memory ...
Brito, Verónica, Ginés Padrós, Silvia
openaire +3 more sources
Rabies Virus Hijacks and accelerates the p75NTR retrograde axonal transport machinery. [PDF]
PLoS Pathogens, 2014 Rabies virus (RABV) is a neurotropic virus that depends on long distance axonal transport in order to reach the central nervous system (CNS). The strategy RABV uses to hijack the cellular transport machinery is still not clear.
Shani Gluska +6 more
doaj +1 more source
Nerve Growth Factor Regulates the Firing Patterns and Synaptic Composition of Motoneurons [PDF]
, 2010 Target-derived neurotrophins exert powerful synaptotrophic actions in the adult brain and are involved in the regulation of different forms of synaptic plasticity.
Davis López de Carrizosa, María América +4 more
core +1 more source