Results 121 to 130 of about 2,196,996 (280)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

In situ structures of the portal-neck-tail complex of bacteriophage T4 inform a viral genome positioning mechanism

Nature Communications
The post-genome packaging mechanisms that govern the assembly of an infectious virion are poorly understood in bacteriophages and other viruses. Here, our near-atomic resolution cryo-EM structural analyses uncovered an assembly- and conformation-driven ...
Andrei Fokine, Jingen Zhu, Thomas Klose, Frank Vago, Charles-Adrien Arnaud, Zhiqing Wang, Baldeep Khare, Michael G. Rossmann, Zhenguo Chen, Lei Sun, Qianglin Fang, Richard J. Kuhn, Venigalla B. Rao   +12 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Influence of packaging design on littering behavior

, 2006
Litter is an environmental and social problem that is closely related to packaging. Many attempts have been made to reduce litter. So far these attempts have mainly focused on influencing littering behavior either through general campaigns or through ...
Wever, R. (author)
core  

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Investigation on the development and characterization of barkcloth-velvetleaf fiber composites using Taguchi-grey relational analysis for sustainable food packaging applications

Materials Research Express
The rising demand for biodegradable and sustainable packaging materials has generated delicate interest in natural fiber composites, with barkcloth-velvetleaf fiber composites providing a renewable alternative for food packaging applications.
Richard Tukamuhebwa, Milon Selvam Dennison, Joseph Valerian Tesha   +2 more
doaj   +1 more source

Identification of the initial nucleocapsid recognition element in the HIV-1 RNA packaging signal. [PDF]

Proc Natl Acad Sci U S A, 2020
Ding P, Kharytonchyk S, Waller A, Mbaekwe U, Basappa S, Kuo N, Frank HM, Quasney C, Kidane A, Swanson C, Van V, Sarkar M, Cannistraci E, Chaudhary R, Flores H, Telesnitsky A, Summers MF.   +16 more
europepmc   +1 more source

Systole: A python package for cardiac signal synchrony and analysis [PDF]

Journal of Open Source Software, 2022
Nicolas Legrand, Micah Allen
openaire   +2 more sources