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Bu Yang Huan Wu Decoction controls synovitis via HIF-1/VEGF signaling for osteoarthritis therapy. [PDF]

Medicine (Baltimore)
Li X, Lv Y, Yang X, Wang S, Liang Q.
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Paeoniflorin suppresses IL-33 production by macrophages

Immunopharmacology and Immunotoxicology, 2020
Objective: Interleukin (IL)-33 has been attracting more and more attention as a new member of theIL-1 cytokine family in recent years. However, the underlying mechanisms referred to the regulation of endogenous IL-33 production are not fully illustrated.
Weihua Li, Wenting Tao, Jiaojiao Chen, Yi Zhai, Nina Yin, Zhigang Wang   +5 more
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Sodium paeoniflorin sulfonate, a process derived artefact from paeoniflorin

Tetrahedron Letters, 2005
Sodium paeoniflorin sulfonate 2 was isolated from processed, but not unprocessed, Paeonia lactiflora roots and characterized by mass spectrometry and NMR spectroscopy. A notable and characteristic downfield shift in the H-1 NMR was observed for the hydrogens to the alkoxysulfonate moiety in 2 and in other model compounds. (c) 2005 Elsevier Ltd.
Hayes, P. Y. N., Lehmann, R. P., Penman, K. G., Kitching, W., De Voss, J. J.   +4 more
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Detection of Paeoniflorin and Albiflorin by Immunostaining Technique Using Anti‐Paeoniflorin Monoclonal Antibody

Phytochemical Analysis, 2012
ABSTRACTIntroductionPaeoniae radix is one of the most important crude drugs used in Kampo medicines (KMs). A part of its pharmaceutical properties is due to the presence of paeoniflorin (PF) and albiflorin (AF).ObjectiveFor the specific and easy identification of PF and AF, an immunostaining technique was developed using anti‐PF monoclonal antibody ...
Osamu, Morinaga, Zhaohua, Lu, Lidong, Lin, Takuhiro, Uto, Suphattra, Sangmalee, Waraporn, Putalun, Hiroyuki, Tanaka, Yukihiro, Shoyama   +7 more
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Microbiological transformation of paeoniflorin and albiflorin

China Journal of Chinese Matera Medica, 2010
To investigate the microbiological transformation of paeoniflorin and albiflorin.The bacteria strains able to transform paeoniflorin and albiflorin were screened from 18 strains of microorganisms. The products were isolated by chromatography method and their structures were elucidated by spectral technology.It was found that Cunninghamella blakesleana (
Xinxin, Liu, Xiaochi, Ma, Changhong, Huo, Shuhong, Yu, Qiao, Wang   +4 more
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Paeoniflorin inhibits macrophage-mediated lung cancer metastasis

Chinese Journal of Natural Medicines, 2015
Alternatively activated macrophages are more frequently involved in tumor growth, angiogenesis, and immunosuppression. A previous study showed that paeoniflorin, the major active constituent of Paeonia lactiflora Pallas, can inhibit tumor growth and lung metastases of Lewis lung tumor-bearing mice.
Qi, Wu, Gang-Ling, Chen, Ya-Juan, Li, Yang, Chen, Fang-Zhen, Lin   +4 more
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Paeoniflorin attenuates allergic inflammation in asthmatic mice

International Immunopharmacology, 2015
Paeoniflorin (PF), one of the major active ingredients of Chinese peony, has demonstrated anti-inflammatory and immunoregulatory effects. However, it has remained unclear whether PF treatment can inhibit allergic inflammation in asthma. In this study, we evaluated the effects of PF on pulmonary function and airway inflammation in asthmatic mice.
Jing, Sun, Jinfeng, Wu, Changqing, Xu, Qingli, Luo, Bei, Li, Jingcheng, Dong   +5 more
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Involvement of Multitargets in Paeoniflorin-Induced Preconditioning

The Journal of Pharmacology and Experimental Therapeutics, 2006
Paeoniflorin (PF) is the principal component of Paeoniae radix prescribed in traditional Chinese medicine. The delayed neuroprotection induced by PF preconditioning and its underlying mechanisms were investigated in rat middle cerebral artery occlusion (MCAO) and reperfusion model.
Dong-Mei, Chen, Liang, Xiao, Xin, Cai, Rong, Zeng, Xing-Zu, Zhu   +4 more
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