Results 191 to 200 of about 9,582 (244)

Paeoniflorin modulates AGEs/RAGE/P38MAPK/ERK/mTOR autophagy pathway to improve cognitive dysfunction in MRL/lpr mice.

International Journal of Biological Macromolecules
OBJECTIVE The objective of this study was to investigate the therapeutic effects of paeoniflorin (PA) on cognitive impairment and to elucidate its potential mechanisms in MRL/lpr mice, a model of systemic lupus erythematosus-associated cognitive ...
Honghui Tang, Tianzhen Ma, Yanxin Wang, Chuanmeng Zhang, Yuanding Chu, Yuqing Guo, Jin Xi, Dongliang Jiao, Baiqing Li, Changhao Xie, Yuanyuan Wang   +10 more
semanticscholar   +1 more source

Paeoniflorin attenuates polystyrene nanoparticle-induced reduction in reproductive capacity and increase in germline apoptosis through suppressing DNA damage checkpoints in Caenorhabditis elegans.

Science of the Total Environment, 2023
Due to high sensitivity to environmental exposures, Caenorhabditis elegans is helpful for toxicity evaluation and toxicological study of pollutants. Using this animal model, we investigated the reproductive toxicity of 20 nm polystyrene nanoparticle (PS ...
Xin Hua, Xiaoli Feng, Yingshun Hua, Dayong Wang   +3 more
semanticscholar   +1 more source

Paeoniflorin confers ferroptosis resistance by regulating the gut microbiota and its metabolites in diabetic cardiomyopathy.

American Journal of Physiology - Cell Physiology
Diabetic cardiomyopathy (DCM) is closely related to ferroptosis, a new type of cell death that mainly manifests as intracellular iron accumulation and lipid peroxidation.
Haowei Wu, Peipei Zhang, Jiedong Zhou, Songqing Hu, Jinjin Hao, Zuoquan Zhong, Haijun Yu, Juntao Yang, Hangyuan Guo, Jufang Chi   +9 more
semanticscholar   +1 more source

Paeoniflorin protects the vascular endothelial barrier in mice with sepsis by activating RXRα signaling.

Phytomedicine
OBJECTIVE Sepsis is a life-threatening condition characterized by organ dysfunction resulting from the body's aberrant response to infection. A primary indicator of early sepsis is vascular leakage due to endothelial injury.
Xinyue Cao, Ruihua Ma, Yirui Wang, Yuran Huang, Keyuan You, Lijie Zhang, Haidong Li, Guize Feng, Tongqing Chen, Dong Wang, Keyu Sun, Hao Fang, Xiaoyan Shen   +12 more
semanticscholar   +1 more source

Paeoniflorin suppresses neuronal ferroptosis to improve the cognitive behaviors in Alzheimer's disease mice

Phytotherapy Research, 2023
Aim of this research was to examine the impact of paeoniflorin (Pae) in suppressing the occurrence of ferroptosis in individuals with Alzheimer's disease (AD). The study utilized APP/PS1 mice with AD as the experimental subjects.
L. Zhai, Hong-yan Pei, Heping Shen, Yi Yang, Chenyang Han, Q. Guan   +5 more
semanticscholar   +1 more source

Paeoniflorin attenuates allergic inflammation in asthmatic mice

International Immunopharmacology, 2015
Paeoniflorin (PF), one of the major active ingredients of Chinese peony, has demonstrated anti-inflammatory and immunoregulatory effects. However, it has remained unclear whether PF treatment can inhibit allergic inflammation in asthma. In this study, we evaluated the effects of PF on pulmonary function and airway inflammation in asthmatic mice.
Jing, Sun, Jinfeng, Wu, Changqing, Xu, Qingli, Luo, Bei, Li, Jingcheng, Dong   +5 more
openaire   +2 more sources

Paeoniflorin suppresses IL-33 production by macrophages

Immunopharmacology and Immunotoxicology, 2020
Objective: Interleukin (IL)-33 has been attracting more and more attention as a new member of theIL-1 cytokine family in recent years. However, the underlying mechanisms referred to the regulation of endogenous IL-33 production are not fully illustrated.
Weihua Li, Wenting Tao, Jiaojiao Chen, Yi Zhai, Nina Yin, Zhigang Wang   +5 more
openaire   +2 more sources

Development of Fluorescence-Linked Immunosorbent Assay for Paeoniflorin

Journal of Fluorescence, 2015
In this study, we developed a fluorescent immunoassay approach to detect paeoniflorin (PF) using a fluorescently labelled monoclonal antibody. The PF-specific antibody was purified by the caprylic acid-ammonium sulfate method and protein G Sepharose 4 Fast Flow column and then labelled with fluorescein isothiocyanate (FITC).
Yan, Zhao, Huihua, Qu, Xueqian, Wang, Yue, Zhang, Jinjun, Cheng, Yan, Zhao, Qingguo, Wang   +6 more
openaire   +2 more sources

Paeoniflorin suppresses ferroptosis after traumatic brain injury by antagonizing P53 acetylation.

Phytomedicine
BACKGROUND Traumatic brain injury (TBI) could induce multiple forms of cell death, ferroptosis, a novel form of cell death distinct from apoptosis and autophagy, plays an important role in disease progression in TBI.
Simin Zhi, Yue Cui, Yang Liu, Jiatong Zhang, Xiao-Jian Li, Bin Sheng, Xiang-xin Chen, Chaolong Yan, Wei Li, Jian-Nan Mao, Hui-ying Yan, Wei Jin   +11 more
semanticscholar   +1 more source

The interactions of paeoniflorin and veratrine on isolated rat atria

Journal of Ethnopharmacology, 1997
In this study, we attempted to identify the interactions and mechanisms between veratrine and paeoniflorin on isolated rat atria. Paeoniflorin alone showed no effect on the rat atria. Veratrine increased the atrial contraction and induced arrhythmia at 1 x 10(-5) g/ml. Veratrine could directly induce contraction and elicit tetanic contraction at 1 x 10(
H Y, Tsai, Y T, Lin, Y F, Chen, C F, Chen   +3 more
openaire   +2 more sources