Results 201 to 210 of about 9,582 (244)

Paeoniflorin inhibits the inflammation of rheumatoid arthritis fibroblast-like synoviocytes by downregulating hsa_circ_009012

Heliyon
Background Rheumatoid arthritis (RA) is a chronic inflammatory disease that leads to progressive joint damage. Circular RNA (circRNA) can regulate the inflammatory response of fibroblast-like synoviocytes (FLSs) in RA, influencing the disease progression.
Junping Yang, Zehong Wei, Huaiyu Li, Senhao Lv, Yong Fu, Ling Xiao   +5 more
semanticscholar   +1 more source

Synthesis and antioxidant activity of paeoniflorin derivatives

Bioorganic Chemistry
Paeoniflorin has multiple protective effects on the nervous system. However, its low bioavailability limits the exertion of its efficacy. In this study, a series of esterified derivatives of the alkyl groups of paeoniflorin were designed and synthesized through the strategies of group protection and alkyl acylation.
Qian, Xiao, YuXiang, Song, Meng, Yang, MingTao, Wang, HaiYi, Gao, XinYue, Zheng, Peiliang, Dong, Hua, Han   +7 more
openaire   +2 more sources

Effects of veratrine and paeoniflorin on the isolated rat aorta

Journal of Ethnopharmacology, 1999
The interactions and mechanisms between veratrine and paeoniflorin on the isolated rat aorta were studied. Veratrine (1x10(-6) to 1x10(-4) g/ml) could induce contraction on the isolated rat aorta in a concentration-related manner. Paeoniflorin had no effect on the isolated rat aorta.
H Y, Tsai, Y T, Lin, C F, Chen, C H, Tsai, Y F, Chen   +4 more
openaire   +2 more sources

Metabolism of paeoniflorin by rat intestinal flora in vitro

China Journal of Chinese Materia Medica, 2016
In order to clarify the effect of intestinal flora on the absorption and metabolism of paeoniflorin in vivo, the metabolism of paeoniflorin by rat intestinal flora was studied under the in vitro anaerobic condition. Paeoniflorin was incubated with rat anaerobic intestinal flora for 48 h, and UPLC was used to detect the changes of paeoniflorin at ...
Zhong-Cheng, Ke, Nan, Yang, Xue-Feng, Hou, Ai-Dong, Wang, Liang, Feng, Xiao-Bin, Jia   +5 more
openaire   +2 more sources

Paeoniflorin inhibited GSDMD to alleviate ANIT-induced cholestasis via pyroptosis signaling pathway.

Phytomedicine
BACKGROUND Cholestasis (CT) is a group of disorders caused by impaired production, secretion or excretion of bile. This may result in the deposition of bile components in the blood and liver, which in turn causes damage to liver cells and other tissues ...
Xiao Ma, Wenwen Zhang, Yuan Chen, Qichao Hu, Zexin Wang, Tao Jiang, Yi Zeng, Thomas Efferth   +7 more
semanticscholar   +1 more source

Paeoniflorin regulates microglia-astrocyte crosstalk, inhibits inflammatory response, and alleviates neuropathic pain through HSP90AA1/HMGB1 signaling pathway.

International Journal of Biochemistry and Cell Biology
Given the unclear, complex pathogenesis of neuropathic pain and the potential of paeoniflorin in relieving neuropathic pain, this study aimed to further clarify the therapeutic effect of paeoniflorin on neuropathic pain and to preliminarily explore the ...
Feng Luo, Juan Zhang, Y. Miao, Danhong Wu, Hong Shen, Man Lu   +5 more
semanticscholar   +1 more source

[Progressive studies of paeoniflorin].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2009
Paeoniflorin is one of the bioactive components of Paeonia lactiflora, a traditional Chinese herbal medicine. It is the main monoterpene glucoside isolated from the P. lactiflora in 1963. Since then, researchers have found that paeoniflorin has multifold pharmacological effects.
Li-Rong, Sun, Xiong, Cao, Feng-Qing, Hou, Xin-Hong, Zhu, Tian-Ming, Gao   +4 more
openaire   +1 more source

Contents of paeoniflorin and albiflorin in two Korean landraces of Paeonia lactiflora and characterization of paeoniflorin biosynthesis genes in peony

Genes & Genomics
Paeoniflorin and albiflorin are monoterpene glycosides that exhibit various medicinal properties in Paeonia species. This study explored the terpene biosynthesis pathway and analyzed the distribution of these compounds in different tissues of two Korean landraces of Paeonia lactiflora to gain insights into the biosynthesis of monoterpene glycosides in ...
Seungki Lee, Nam-Il Park, Yeri Park, Kweon Heo, Yongsoo Kwon, Eun Sil Kim, Youn Kyoung Son, Kyung Jin Lee, Seung Young Choi, Beom-Soon Choi, Nam-Soo Kim, Ik-Young Choi   +11 more
openaire   +2 more sources

Paeoniflorin alleviates DSS-induced ulcerative colitis by suppressing inflammation, oxidative stress, and apoptosis via regulating serum metabolites and inhibiting CDC42/JNK signaling pathway.

International Immunopharmacology
Ulcerative colitis (UC) poses a threat to human health. The present study attempts to unravel the efficacy and potential mechanisms of paeoniflorin (PF), a naturally sourced active ingredient, for the management of UC.
Qichao Hu, Jin Xie, Tao Jiang, Pan Gao, Yuan Chen, Wenwen Zhang, Jin Yan, Jinhao Zeng, Xiao Ma, Yanling Zhao   +9 more
semanticscholar   +1 more source

Paeoniflorin mitigates MMP-12 inflammation in silicosis via Yang-Yin-Qing-Fei Decoction in murine models.

Phytomedicine
BACKGROUND Silicosis presents a significant clinical challenges and economic burdens, with Traditional Chinese Medicine (TCM) emerging as a potential therapeutic avenue.
Tian Li, N. Mao, Zihao Xie, Jianing Wang, F. Jin, Yaqian Li, Shupeng Liu, Wenchen Cai, Xuemin Gao, Zhongqiu Wei, Fang Yang, Hong Xu, Heliang Liu, Haibo Zhang, Dingjie Xu   +14 more
semanticscholar   +1 more source