Results 11 to 20 of about 6,965 (203)

Paeoniflorin Enhances Endometrial Receptivity through Leukemia Inhibitory Factor [PDF]

open access: yesBiomolecules, 2021
Despite advances in assisted reproductive technology, treatment for deficient endometrial receptivity is a major clinical unmet need. In our previous study, the water extract of Paeonia lactiflora Pall.
Hye-Rin Park   +8 more
doaj   +3 more sources

A Buffered LC-MS Method for Resolving and Quantifying Albiflorin and Paeoniflorin. [PDF]

open access: yesBiomed Chromatogr
ABSTRACT Albiflorin and paeoniflorin are bioactive isomers found in Paeoniae Radix Alba, a key component of Traditional Chinese Medicine. Their accurate and simultaneous quantification is essential for pharmacological research. Standard separation methods often rely on LC‐MS using a mobile phase containing 0.1% formic acid. This study demonstrates that
Gazizova A, Altincubuk EH, Oppermann C.
europepmc   +2 more sources

Multiple Roles of Paeoniflorin in Alzheimer’s Disease

open access: yesEvidence-Based Complementary and Alternative Medicine, 2022
Alzheimer’s disease (AD) is a geriatric disease with the morbidity and mortality continuing to grow, partly due to the aging of the world population. As one of the most common types of primary neurodegenerative dementia, it is mainly due to environmental, epigenetic, immunological, and genetic factors.
Zeyu Meng   +3 more
openaire   +3 more sources

The effects and mechanism of paeoniflorin in promoting osteogenic differentiation of MC3T3-E1

open access: yesJournal of Orthopaedic Surgery and Research, 2022
Background The incidence of osteoporosis and osteoporotic fractures is increasing every year. Traditional Chinese Medicine (TCM) can shed new light on the treatment of osteoporosis.
Wei Guo   +3 more
doaj   +1 more source

Paeoniflorin Ameliorates Skeletal Muscle Atrophy in Chronic Kidney Disease via AMPK/SIRT1/PGC-1α-Mediated Oxidative Stress and Mitochondrial Dysfunction

open access: yesFrontiers in Pharmacology, 2022
Skeletal muscle atrophy is a common and serious complication of chronic kidney disease (CKD). Oxidative stress and mitochondrial dysfunction are involved in the pathogenesis of muscle atrophy.
Qiang Li   +9 more
doaj   +1 more source

Integrating Metabolomics and Network Analysis for Exploring the Mechanism Underlying the Antidepressant Activity of Paeoniflorin in Rats With CUMS-Induced Depression

open access: yesFrontiers in Pharmacology, 2022
Background: Paeoniflorin (PF) represents the major bioactive constituent of the traditional Chinese medicine plant Paeonia suffruticosa (Ranunculaceae), which has a long history as a folk medicine in Asian.
Chaofang Lei   +11 more
doaj   +1 more source

Paeoniflorin Ameliorates Hyperprolactinemia-Induced Inhibition of Osteoblastogenesis by Suppressing the NF-κB Signaling Pathway

open access: yesInternational Journal of Endocrinology, 2022
Hyperprolactinemia is a common endocrine disease in women of reproductive age. Research has shown that patients with hyperprolactinemia often have decreased bone mineral density and an increased risk of fractures.
Xiaohong Sun   +10 more
doaj   +1 more source

Paeoniflorin alleviates 17α-ethinylestradiol-induced cholestasis via the farnesoid X receptor-mediated bile acid homeostasis signaling pathway in rats

open access: yesFrontiers in Pharmacology, 2022
Cholestasis, characterized by disturbance of bile formation, is a common pathological condition that can induce several serious liver diseases. As a kind of trigger, estrogen-induced cholestasis belongs to drug-induced cholestasis.
Rulin Wang   +16 more
doaj   +1 more source

Gut Microbiota-Based Pharmacokinetics and the Antidepressant Mechanism of Paeoniflorin

open access: yesFrontiers in Pharmacology, 2019
Paeoniflorin, the main component of Xiaoyao Wan, presents low oral bioavailability and unclear antidepressant mechanism. To elucidate the potential reasons for the low bioavailability of paeoniflorin and explore its antidepressant mechanism from the ...
Jin-Bo Yu   +12 more
doaj   +1 more source

Pharmacokinetic interaction between peimine and paeoniflorin in rats and its potential mechanism

open access: yesPharmaceutical Biology, 2021
Context Peimine and paeoniflorin can be combined for the treatment of cough in paediatrics. The interaction during the co-administration could dramatically affect the bioavailability of drugs.
Qiangjun Chen   +4 more
doaj   +1 more source

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