Results 41 to 50 of about 4,897 (175)

Therapeutic potential of paeoniflorin in atherosclerosis: A cellular action and mechanism-based perspective

Frontiers in Immunology, 2022
Epidemiological studies have shown that the incidence, prevalence and mortality of atherosclerotic cardiovascular disease (ASCVD) are increasing globally.
Wei Yu, Wei Yu, Iqra Ilyas, Xuerui Hu, Suowen Xu, Hui Yu   +5 more
doaj   +1 more source

Effect of Tokishakuyakusan on Anemia in a Rat Model of Salt‐Sensitive Hypertension

Traditional &Kampo Medicine, Volume 13, Issue 2, August 2026.
ABSTRACT Aim Anemia is prevalent in patients with cardiac and renal diseases and is associated with morbidity and mortality. Consequently, new strategies for managing anemia are expected in these patients. Tokishakuyakusan, a Kampo medicine, is clinically used to treat various conditions, such as anemia and chronic nephritis.
Yoshiro Naito, Takeshi Tsujino, Masanori Asakura, Masaharu Ishihara   +3 more
wiley   +1 more source

Paeoniflorin, a Natural Product With Multiple Targets in Liver Diseases—A Mini Review

Frontiers in Pharmacology, 2020
Paeoniflorin is derived from Paeonia suffruticosa Andr., Paeonia lactiflora Pall., or Paeonia veitchii Lynch and has been used in traditional medical applications for more than 2,000 years.
Xiao Ma, Wenwen Zhang, Yinxiao Jiang, Jianxia Wen, Jianxia Wen, Shizhang Wei, Shizhang Wei, Yanling Zhao   +7 more
doaj   +1 more source

Effects of Paeoniflorin on Anxiety-like Behavior, Inflammatory Factors and Intestinal Microflora in Alcohol Withdrawal Rats

Shipin gongye ke-ji, 2022
Objective: To explore the effects of paeoniflorin on alcohol withdrawal induced anxiety-like behavior, inflammatory factors and intestinal microorganisms in a long-term low-dose drinking and then withdrawal rats model.
Xiaolong WANG, Shuang WU, Qi WU, Jin WANG, Zhenglin ZHAO, Chunjing ZHANG, Lin LI   +6 more
doaj   +1 more source

The Impact of Paeoniflorin onα-Synuclein Degradation Pathway [PDF]

Evidence-Based Complementary and Alternative Medicine, 2015
Paeoniflorin (PF) is the major active ingredient in the traditional Chinese medicine Radix. It plays a neuroprotective role by regulating autophagy and the ubiquitin-proteasome degradation pathway. In this study, we found PF significantly reduced cell damage caused by MPP+, returning cells to normal state. Cell viability significantly improved after 24
Cai, Zenglin, Zhang, Xinzhi, Zhang, Yongjin, Li, Xiuming, Xu, Jing, Li, Xiaomin   +5 more
openaire   +2 more sources

Research on the Mechanism of Natural Products Acting on Chronic Obstructive Pulmonary Disease

Food Science &Nutrition, Volume 14, Issue 7, July 2026.
This figure illustrates that approximately 80 natural compounds exert therapeutic effects against chronic obstructive pulmonary disease by targeting pathological mechanisms such as airway inflammation, oxidative stress, airway remodeling, mucus hypersecretion, emphysema, protease–antiprotease imbalance, apoptosis, and autophagy.
Shuna Wei, Xiaoju Liu
wiley   +1 more source

Paeoniflorin Inhibits ASK1-TF Axis by Up-Regulating SOCS3 to Alleviate Radiation Enteritis

Frontiers in Pharmacology, 2022
Radiation enteritis is one of the main adverse effects of radiotherapy, presenting with a poorly understood etiology and limited options for therapy. Intestinal inflammation and ischemia are the core mechanisms of radiation enteritis.
Lei Sheng, Lei Sheng, Fan Hu, Hanqing Yu, Xueyou Tao, Rumeng Jia, Yufeng Gu, Lu Chen, Hong Kong, Chen Miao, Wenjing Fei, Yang Yang, Jinhui Jia, Xia Zhu, Xueming He, Liang Hu, Jianxin Ma, Wen-Tao Liu, Mi Yang, Mi Yang   +19 more
doaj   +1 more source

The antidepressant-like effects of paeoniflorin in mouse models

Experimental and Therapeutic Medicine, 2013
Peony is often used in Chinese herbal medicine for the treatment of depression-like disorders. Our previous studies have demonstrated that the total glycosides of peony exert antidepressant-like effects in animal models. Paeoniflorin is the main active glycoside of peony.
QIU, FENGMEI, ZHONG, XIAOMING, MAO, QINGQIU, HUANG, ZHEN   +3 more
openaire   +3 more sources

Oxypaeoniflorin Ameliorates Titanium Particle‐Stimulated Osteolysis by Targeting Nrf2 to Reprogram Mitochondrial Homeostasis in Osteoclasts

Journal of Cellular and Molecular Medicine, Volume 30, Issue 13, July 2026.
ABSTRACT Wear debris surrounding implants plays a crucial role in the development of periprosthetic osteolysis (PPO) by inducing the aggregation of osteoclasts around the prosthesis. Oxypaeoniflorin (OPF), a derivative of Paeoniflorin, is primarily sourced from the root of the traditional Chinese medicine peony and possesses anti‐inflammatory and ...
Feng Zhu, Zebin Wu, Jinxuan Hei, Huaqiang Tao, Wenming Li, Kai Chen, Qihan Wang, Dechun Geng, Zhidong Wang, Yaozeng Xu, Shujun Lv   +10 more
wiley   +1 more source

Paeoniflorin attenuates gestational diabetes via Akt/mTOR pathway in a rat model

Food & Nutrition Research, 2020
Background: Gestational diabetes mellitus (GDM) is a type of diabetes associated with pregnancy and may impose risks on both mother and fetus. Akt paeoniflorin was shown to have anti-inflammatory and anti-hyperglycemia properties and has a potential ...
Yonghua Zhang, Yulin Liang, Huiqiao Liu, Ying Huang, Hongmei Li, Bo Chen   +5 more
doaj   +1 more source