Results 21 to 30 of about 4,897 (175)

Pharmacokinetic interaction between peimine and paeoniflorin in rats and its potential mechanism

Pharmaceutical Biology, 2021
Context Peimine and paeoniflorin can be combined for the treatment of cough in paediatrics. The interaction during the co-administration could dramatically affect the bioavailability of drugs.
Qiangjun Chen, Changlong Yin, Yongwei Li, Zhe Yang, Zongying Tian   +4 more
doaj   +1 more source

Paeoniflorin Inhibits Mesangial Cell Proliferation and Inflammatory Response in Rats With Mesangial Proliferative Glomerulonephritis Through PI3K/AKT/GSK-3β Pathway

Frontiers in Pharmacology, 2019
Mesangial proliferative glomerulonephritis (MPGN) is the most common type of chronic kidney disease in China, characterized by mesangial cell proliferation and inflammatory response.
Bihao Liu, Jin Lin, Lixia Bai, Yuan Zhou, Ruirui Lu, Peichun Zhang, Dandan Chen, Honglian Li, Jianping Song, Xusheng Liu, Yifan Wu, Junbiao Wu, Chunling Liang, Jiuyao Zhou   +13 more
doaj   +1 more source

Paeoniflorin alleviates inflammatory response in IBS-D mouse model via downregulation of the NLRP3 inflammasome pathway with involvement of miR-29a

Heliyon, 2022
Paeoniflorin has been traditionally used to treat pain and immunologic derangement in China. However, its detailed mechanism remains to be illuminated.
Wei Ke, Yongfu Wang, Siyu Huang, Shan Liu, He Zhu, Xiangyu Xie, Huifei Yang, Qin Lu, Jianfeng Gan, Guodong He, Fei Che, Xin Wan, Hongmei Tang   +12 more
doaj   +1 more source

Detection of Sulfur-Fumigated Paeoniae Alba Radix in Complex Preparations by High Performance Liquid Chromatography Tandem Mass Spectrometry

Molecules, 2012
Detection of sulfur-fumigated Paeoniae Alba Radix (PAR) in different complex preparations is challenging due to the relatively lower content of PAR and interference from more complicated components in complex preparations with different multiple ...
Song-Lin Li, Ling-Ying Zhu, Xiao-Bin Jia, Jun Xu, Hong Shen, Jie Wu   +5 more
doaj   +1 more source

Network pharmacology and in vivo studies reveal the neuroprotective effects of paeoniflorin on Alzheimer's disease

Heliyon, 2023
Alzheimer's disease (AD) is a progressive neurodegenerative disease that has still not been effectively treated. Paeoniflorin is a traditional Chinese medicine with potential neuroprotective effects against brain injury; however, the beneficial effects ...
Mengyuan Zhang, Haoran Zheng, Jiale He, Mei Zhang   +3 more
doaj   +1 more source

Absorption and Excretion of Paeoniflorin in Rats

Journal of Pharmacy and Pharmacology, 1995
Abstract The absorption and excretion of paeoniflorin after intravenous and oral administration was studied in rats to evaluate the significance of paeoniflorin in the pharmacological action of Paeony root. The plasma concentration of paeoniflorin after intravenous administration at the doses of 0.5, 2.0 and 5.0 mg kg−1 ...
S, Takeda, T, Isono, Y, Wakui, Y, Matsuzaki, H, Sasaki, S, Amagaya, M, Maruno   +6 more
openaire   +2 more sources

Metabolism studies of paeoniflorin in rat liver microsomes by ultra-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS/MS) [PDF]

Royal Society Open Science, 2018
To explore metabolism mechanism of paeoniflorin in the liver and further understand intact metabolism process of paeoniflorin, a rapid, convenient and effective assay is described using ultra-performance liquid chromatography coupled with hybrid ...
L. J. Zhu, S. S. Sun, Y. X. Hu, Y. F. Liu   +3 more
doaj   +1 more source

Paeoniflorin drives the immunomodulatory effects of mesenchymal stem cells by regulating Th1/Th2 cytokines in oral lichen planus

Scientific Reports, 2022
Lichen planus (LP) is a chronic inflammatory disease. Oral lichen planus (OLP) mainly appears as oral mucosal reticular or ulcerative lesions with an unknown etiology.
Zhihui Zhang, Yan Zhang, Zhongfang Zhao, Pei Li, Danyang Chen, Wei Wang, Ying Han, Shiqi Zou, Xin Jin, Jianling Zhao, Hongwei Liu, Xiao Wang, Weili Zhu   +12 more
doaj   +1 more source

Effects of glycyrrhizin on the pharmacokinetics of paeoniflorin in rats and its potential mechanism

Pharmaceutical Biology, 2019
Context: Paeoniflorin is reported to possess numerous pharmacological activities. Paeoniflorin and glycyrrhizin are always used together for the treatment of disease in China clinics; however, the drug–drug interaction between glycyrrhizin and ...
Hongjuan Sun, Jingfeng Wang, Juan Lv
doaj   +1 more source

Comparison of Paeoniflorin and Albiflorin on Human CYP3A4 and CYP2D6 [PDF]

Evidence-Based Complementary and Alternative Medicine, 2015
Peony (Paeonia lactifloraPall-) is a plant medicine and a functional food ingredient with wide application for more than 2000 years. It can be coadministrated with many other drugs, composed of traditional Chinese medicine compound such as shaoyao-gancao decoction.
Gao, Li-Na, Zhang, Ye, Cui, Yuan-Lu, Akinyi, Olunga Mary   +3 more
openaire   +2 more sources