Results 11 to 20 of about 4,897 (175)

A review for the pharmacological effects of paeoniflorin in the nervous system

Frontiers in Pharmacology, 2022
Paeoniflorin, a terpenoid glycoside compound extracted from Paeonia lactiflora Pall, shows preventive and therapeutic effects in various types of nervous system disorders.
Hongxiang Hong, Xu Lu, Chunshuai Wu, Jiajia Chen, Chu Chen, Jinlong Zhang, Chao Huang, Zhiming Cui   +7 more
doaj   +3 more sources

A Buffered LC-MS Method for Resolving and Quantifying Albiflorin and Paeoniflorin. [PDF]

Biomed Chromatogr
ABSTRACT Albiflorin and paeoniflorin are bioactive isomers found in Paeoniae Radix Alba, a key component of Traditional Chinese Medicine. Their accurate and simultaneous quantification is essential for pharmacological research. Standard separation methods often rely on LC‐MS using a mobile phase containing 0.1% formic acid. This study demonstrates that
Gazizova A, Altincubuk EH, Oppermann C.
europepmc   +2 more sources

Multiple Roles of Paeoniflorin in Alzheimer’s Disease

Evidence-Based Complementary and Alternative Medicine, 2022
Alzheimer’s disease (AD) is a geriatric disease with the morbidity and mortality continuing to grow, partly due to the aging of the world population. As one of the most common types of primary neurodegenerative dementia, it is mainly due to environmental, epigenetic, immunological, and genetic factors.
Zeyu Meng, Huize Chen, Chujun Deng, Shengxi Meng   +3 more
openaire   +3 more sources

The effects and mechanism of paeoniflorin in promoting osteogenic differentiation of MC3T3-E1

Journal of Orthopaedic Surgery and Research, 2022
Background The incidence of osteoporosis and osteoporotic fractures is increasing every year. Traditional Chinese Medicine (TCM) can shed new light on the treatment of osteoporosis.
Wei Guo, Xiao-guang Yang, Yu-lin Shi, Hong Wang   +3 more
doaj   +1 more source

Protein Tyrosine Phosphatase 1B-Mediated Granulosa Cell Insulin Resistance Links Metabolic Stress to Aging-Relevant Ovarian Dysfunction and Is Reversed by Gengnianchun. [PDF]

Aging Cell
Metabolic stress induces insulin resistance and upregulates PTP1B in granulosa cells, leading to aging‐relevant ovarian dysfunction. Gengnianchun (GNC) suppresses PTP1B, restores IRS1–AKT2–GLUT4 signaling, and preserves follicles, highlighting PTP1B as a therapeutic target for ovarian dysfunction in metabolically vulnerable states.
Rao Y, Xu T, Ding Y, Li J, Gao L, Wang Y, Wang W.   +6 more
europepmc   +2 more sources

Paeoniflorin Ameliorates Skeletal Muscle Atrophy in Chronic Kidney Disease via AMPK/SIRT1/PGC-1α-Mediated Oxidative Stress and Mitochondrial Dysfunction

Frontiers in Pharmacology, 2022
Skeletal muscle atrophy is a common and serious complication of chronic kidney disease (CKD). Oxidative stress and mitochondrial dysfunction are involved in the pathogenesis of muscle atrophy.
Qiang Li, Qiang Li, Jing Wu, Jiawen Huang, Jiawen Huang, Rong Hu, Haiyan You, Lingyu Liu, Dongtao Wang, Lianbo Wei   +9 more
doaj   +1 more source

Integrating Metabolomics and Network Analysis for Exploring the Mechanism Underlying the Antidepressant Activity of Paeoniflorin in Rats With CUMS-Induced Depression

Frontiers in Pharmacology, 2022
Background: Paeoniflorin (PF) represents the major bioactive constituent of the traditional Chinese medicine plant Paeonia suffruticosa (Ranunculaceae), which has a long history as a folk medicine in Asian.
Chaofang Lei, Zhigang Chen, Lili Fan, Zhe Xue, Jianbei Chen, Xihong Wang, Zhen Huang, Yinian Men, Mingzhi Yu, Yueyun Liu, Jiaxu Chen, Jiaxu Chen   +11 more
doaj   +1 more source

Paeoniflorin Ameliorates Hyperprolactinemia-Induced Inhibition of Osteoblastogenesis by Suppressing the NF-κB Signaling Pathway

International Journal of Endocrinology, 2022
Hyperprolactinemia is a common endocrine disease in women of reproductive age. Research has shown that patients with hyperprolactinemia often have decreased bone mineral density and an increased risk of fractures.
Xiaohong Sun, Keda Zhu, Chengcheng Feng, Jie Zhu, Shuangshuang Chen, Wenkai Tang, Zhifang Wang, Long Xiao, Hong Li, Dechun Geng, Zhirong Wang   +10 more
doaj   +1 more source

Retinal Ischemia: Therapeutic Effects and Mechanisms of Paeoniflorin. [PDF]

Int J Mol Sci
Retinal ischemia is a key factor in the progression of vision-threatening ocular diseases, including central retinal artery/vein occlusion, exudative age-related macular degeneration (eAMD), and proliferative diabetic retinopathy. This study investigates the effects of paeoniflorin along with its related neuroprotective molecular pathways in the ...
Chao WW, Chao HW, Peng PH, Lee YT, Chao HM.   +4 more
europepmc   +4 more sources

Paeoniflorin alleviates 17α-ethinylestradiol-induced cholestasis via the farnesoid X receptor-mediated bile acid homeostasis signaling pathway in rats

Frontiers in Pharmacology, 2022
Cholestasis, characterized by disturbance of bile formation, is a common pathological condition that can induce several serious liver diseases. As a kind of trigger, estrogen-induced cholestasis belongs to drug-induced cholestasis.
Rulin Wang, Rulin Wang, Tengteng Yuan, Tengteng Yuan, Jing Sun, Menghuan Yang, Menghuan Yang, Yunna Chen, Yunna Chen, Lei Wang, Lei Wang, Yanyan Wang, Yanyan Wang, Weidong Chen, Weidong Chen, Daiyin Peng, Daiyin Peng   +16 more
doaj   +1 more source