Results 21 to 30 of about 6,965 (203)
Pharmacokinetic comparisons of Paeoniflorin and Paeoniflorin-6'O-benzene sulfonate in rats via different routes of administration [PDF]
Xenobiotica, 2016 1. The pharmacokinetics study of Paeoniflorin (Pae) and its acylated derivative (CP-25) was performed. 2. The structure of CP-25 was identified by mass spectrometry (MS) and nuclear magnetic resonance spectroscopy (NMR). The rats were injected with CP-25(6, 12, 24 mg/kg) and orally treated with CP-25 (32, 64, 128 mg/kg), respectively.
Chun, Wang +3 more
openaire +2 more sources
Frontiers in Pharmacology, 2019 Mesangial proliferative glomerulonephritis (MPGN) is the most common type of chronic kidney disease in China, characterized by mesangial cell proliferation and inflammatory response.
Bihao Liu +13 more
doaj +1 more source
Heliyon, 2022 Paeoniflorin has been traditionally used to treat pain and immunologic derangement in China. However, its detailed mechanism remains to be illuminated.
Wei Ke +12 more
doaj +1 more source
Hepatic stellate cells and parasite-induced liver fibrosis [PDF]
, 2010 : Fibrogenesis is a common feature of many diseases where there is severe insult to the liver. The hepatic stellate cell trans-differentiation into a myofibroblast has been identified as an important event in liver fibrogenesis and has been well ...
Allen, JT +3 more
core +2 more sources
Paeoniflorin, a novel heat shock protein–inducing compound [PDF]
Cell Stress & Chaperones, 2004 Heat shock proteins (HSPs) are induced by various physical, chemical, and biological stresses. HSPs are known to function as molecular chaperones, and they not only regulate various processes of protein biogenesis but also function as lifeguards against proteotoxic stresses.
Dai, Yan +4 more
openaire +2 more sources
Heliyon, 2023 Alzheimer's disease (AD) is a progressive neurodegenerative disease that has still not been effectively treated. Paeoniflorin is a traditional Chinese medicine with potential neuroprotective effects against brain injury; however, the beneficial effects ...
Mengyuan Zhang +3 more
doaj +1 more source
Molecules, 2012 Detection of sulfur-fumigated Paeoniae Alba Radix (PAR) in different complex preparations is challenging due to the relatively lower content of PAR and interference from more complicated components in complex preparations with different multiple ...
Song-Lin Li +5 more
doaj +1 more source
Metabolism studies of paeoniflorin in rat liver microsomes by ultra-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS/MS) [PDF]
Royal Society Open Science, 2018 To explore metabolism mechanism of paeoniflorin in the liver and further understand intact metabolism process of paeoniflorin, a rapid, convenient and effective assay is described using ultra-performance liquid chromatography coupled with hybrid ...
L. J. Zhu +3 more
doaj +1 more source
Iridoids and other Mmnoterpenes in the Alzheimer’s Brain: Recent development and future prospects [PDF]
, 2018 Iridoids are a class of monoterpenoid compounds constructed from 10-carbon skeleton of isoprene building units. These compounds in their aglycones and glycosylated forms exist in nature to contribute to mechanisms related to plant defenses and diverse ...
Habtemariam +11 more
core +2 more sources
Scientific Reports, 2022 Lichen planus (LP) is a chronic inflammatory disease. Oral lichen planus (OLP) mainly appears as oral mucosal reticular or ulcerative lesions with an unknown etiology.
Zhihui Zhang +12 more
doaj +1 more source