Shipin gongye ke-ji, 2022 Objective: To explore the effects of paeoniflorin on alcohol withdrawal induced anxiety-like behavior, inflammatory factors and intestinal microorganisms in a long-term low-dose drinking and then withdrawal rats model.
Xiaolong WANG +6 more
doaj +1 more source
Intranasal delivery of paeoniflorin nanocrystals for brain targeting
Asian Journal of Pharmaceutical Sciences, 2020 Paeoniflorin (PA) is an anti-Parkinson Chinese medicine with inferior bioavailability and difficulty in delivery to the brain. This research is to develop an efficacious PA nanocrystal formulation (PA-NCs) that is suitable for intranasal administration to treat Parkinson's disease (PD). PA-NCs were fabricated through an antisolvent precipitation method
Chaoyin Wu +7 more
openaire +3 more sources
Frontiers in Psychiatry, 2019 Neuronal damage is related to the onset and treatment of depressive disorders. Antidepressant-like effects have been elicited by paeoniflorin on animal models.
Xiaoming Zhong +3 more
doaj +1 more source
Exploring the Therapeutic Mechanism of Xiehuo Pingtu San in Treating Thyroid Eye Disease Based on Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulation [PDF]
Int J EndocrinolBackground Xiehuo Pingtu San (XHPTS) has been shown to be safe and effective in treating thyroid eye disease (TED), yet its underlying mechanisms remain unclear. This study aimed to elucidate the active ingredients of XHPTS and their therapeutic mechanisms in TED through network pharmacology, molecular docking, and molecular dynamics simulations ...
Wang P +5 more
europepmc +2 more sources
赤芍及び Paeonia lactifloraの園芸品種の抗アレルギー作用成分と芍薬関連Paeonia属植物のモノテルペノイドのプロファイリング [PDF]
, 2016 富山大学・富医薬博甲第202号・石 燕紅・2016/03 ...
石 燕紅
core +1 more source
Harnessing Natural Compounds in Psoriasis: Targeting Cellular Pathways for Effective Therapy
Phytotherapy Research, EarlyView.Natural compounds act on key cellular pathways in psoriasis by suppressing keratinocyte hyperproliferation, modulating Th17/IL‐17‐mediated immune responses, and reducing oxidative stress. These multi‐target effects highlight their potential as safer adjunctive therapies alongside conventional treatments.
Hye Jin Lee +9 more
wiley +1 more source
Paeoniflorin ameliorates acquisition impairment of a simple operant discrimination performance caused by unilateral nucleus basalis magnocellularis lesion in rats [PDF]
, 1997 The effect of paeoniflorin on learning impairment of operant brightness discrimination performance was investigated in rats with unilateral nucleus basalis magnocellularis（NBM）lesion.
Akazawa Ko-hei +6 more
core +1 more source
Paeoniflorin selectively inhibits LPS-provoked B-cell function
Journal of Pharmacological Sciences, 2015 B cells are important in the development of autoimmune disorders through mechanisms involving dysregulated polyclonal B-cell activation, production of pathogenic antibodies, and targeting which reduces inflammation and tissue damage effectively but often leads to patients suffering from secondary infection.
Jie Zhang +7 more
openaire +3 more sources
Plants-derived neuroprotective agents: Cutting the cycle of cell death through multiple mechanisms [PDF]
, 2017 Neuroprotection is the preservation of the structure and function of neurons from insults arising from cellular injuries induced by a variety of agents or neurodegenerative diseases (NDs).
Berida, Tomayo Ireti +2 more
core +8 more sources
Paeoniflorin, a Natural Product With Multiple Targets in Liver Diseases—A Mini Review
Frontiers in Pharmacology, 2020 Paeoniflorin is derived from Paeonia suffruticosa Andr., Paeonia lactiflora Pall., or Paeonia veitchii Lynch and has been used in traditional medical applications for more than 2,000 years.
Xiao Ma +7 more
doaj +1 more source