Results 61 to 70 of about 6,965 (203)

Pyroptosis in Peripheral Neuropathy: From Molecular Mechanisms to Therapeutic Targeting

CNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.
Pyroptosis is a key inflammatory cell death pathway in peripheral neuropathy, with opposing roles: it perpetuates neuropathic pain but can be induced to kill neuroblastoma cells. This review consolidates mechanistic understanding and therapeutic strategies, arguing for a shift from disease‐centric to target‐centric treatment approaches to improve ...
Jinhuan Wei, Mingyue Liuyuan, Zhixin Ye, Xueying Wang, Xueli Zhou, Yifan Shan, Cheng He, Chunting Zhu, Chicheng Zhou, Jingyin Bao, Yonghui Zhang, Gang Chen   +11 more
wiley   +1 more source

Metabolism and pharmacokinetics of paeoniflorin, a bioactive component from Peony roots [PDF]

, 2002
Paeoniflorin (PF, yield up to 5.8% of the dry weight) is the major and the most important component of peony roots. Recent studies demonstrate that PF improves the spatial and memory deficits in rodents and suggest possible utilization of this agent in ...
Hattori Masao, Meselhy Meselhy R.
core   +1 more source

An Innovative Formula for Keratosis Pilaris Treatment—A Randomized Controlled Study Based on the “Exfoliation‐Dissolution‐Repair” Concept

Journal of Cosmetic Dermatology, Volume 25, Issue 1, January 2026.
ABSTRACT Objective Keratosis pilaris (KP) is a common follicular keratotic skin disorder characterized by follicular papules and skin roughness, often accompanied by itching and inflammation, significantly affecting appearance and psychological health. Methods This 28‐day prospective, open‐label, randomized controlled study evaluated the effectiveness ...
Fangzhou Liu, Lu Cheng, Jie Yang, Tuowei Li, Jing Li, Xiaojie Zhang, Fengwei Qi, Yuanbai Li, Yang Yang, Yexiang Zhang, Hong Meng   +10 more
wiley   +1 more source

Buyang Huanwu Decoction Alleviates Chronic Intermittent Hypoxia–Induced Myocardial Inflammation and Fibrosis via the NF‐κB/LOX Signaling Pathway

Human Mutation, Volume 2026, Issue 1, 2026.
Objective To investigate the protective effects of Buyang Huanwu decoction (BYHW) on myocardial injury induced by chronic intermittent hypoxia (CIH) in rats and to analyze its potential regulatory mechanism through the NF‐κB/LOX signaling pathway. Methods Then, 36 adult male Sprague–Dawley (SD) rats (weighing 200–250 g) were randomly divided into six ...
Lijun Ou, Chenyi Liu, Weicheng Zhao, Cairu Liu, Ye Ning, Minghua Ren   +5 more
wiley   +1 more source

Absorption and Interaction of the Main Constituents from the Traditional Chinese Drug Pair Shaoyao-Gancao via a Caco-2 Cell Monolayer Model

Molecules, 2012
Shaoyao-Gancao (Paeoniae Radix Alba and Glycyrrhizae Radix et Rhizoma) is a traditional Chinese drug pair widely used in decoctions for relieving pains, especially abdominal pain.
Qingqing Wu, Lianghui Chen, Yan Chen, Lu Wang, Jinyan Wang   +4 more
doaj   +1 more source

Elevating microRNA-122 in blood improves outcomes after temporary middle cerebral artery occlusion in rats. [PDF]

, 2016
Because our recent studies have demonstrated that miR-122 decreased in whole blood of patients and in whole blood of rats following ischemic stroke, we tested whether elevating blood miR-122 would improve stroke outcomes in rats.
Ander, Bradley P, Cox, Christopher, Dykstra-Aiello, Cheryl, Hull, Heather, Jickling, Glen C, Liu, Da Zhi, Sharp, Frank R, Shroff, Natasha, Stamova, Boryana, Zhan, Xinhua   +9 more
core   +2 more sources

Albiflorin‐Mediated MAP2K1 Targeting and HIF‐1 Signaling Inhibition Contribute to the Therapeutic Efficacy in Hyperuricemia‐Associated Cognitive Impairment

Human Mutation, Volume 2026, Issue 1, 2026.
This study investigated the therapeutic effects and mechanisms of Paeonia suffruticosa fruit pod extract (EMP) and its main component albiflorin (AF) on hyperuricemia‐associated cognitive impairment (HUA‐CI). A HUA‐CI mouse model was established, with cognitive function evaluated via Morris water maze.
Huimin Xiao, Xinwen Huang, Rui Yao, Jincai Liu, Linrui Duan, Siwang Wang, Jinming Gao, Minghua Ren   +7 more
wiley   +1 more source

Interaction between Saikosaponin D, Paeoniflorin, and Human Serum Albumin [PDF]

Molecules, 2018
Saikosaponin D (SSD) and paeoniflorin (PF) are the major active constituents of Bupleuri Radix and Paeonia lactiflora Pall, respectively, and have been widely used in China to treat liver and other diseases for many centuries. We explored the binding of SSD/PF to human serum albumin (HSA) by using fluorospectrophotometry, circular dichroism (CD) and ...
Guo-Wu Liang, Yi-Cun Chen, Yi Wang, Hong-Mei Wang, Xiang-Yu Pan, Pei-Hong Chen, Qing-Xia Niu   +6 more
openaire   +2 more sources

Screening for the efficacy on lipid accumulation in 3T3-L1 cells is an effective tool for the identification of new anti-diabetic compounds [PDF]

, 2012
Reducing lipid accumulation in insulin target tissues is critical for the treatment of type 2 diabetes. This study aimed to develop a biochemical assay in cells for high throughput (HTP) screening of anti-diabetic drugs by reducing lipid accumulation via
Chan, S, Molero - Navajas, J, Xu, J, Xue, C, Ye, J, Zeng, X, Zhou, X   +6 more
core   +1 more source

Clinical Efficacy of Traditional Chinese Medicine Chaihu‐Guizhi‐Ganjiang Decoction Combined With Danggui‐Shaoyao‐San for the Treatment of Oligomenorrhea: A Prospective, Open‐Label Clinical Study

International Journal of Clinical Practice, Volume 2026, Issue 1, 2026.
Objective To assess the efficacy and safety of Chaihu‐Guizhi‐Ganjiang decoction (CGGJD) combined with Danggui‐Shaoyao‐San (DS) in oligomenorrhea treatment. Methods In this prospective open‐label trial, 35 oligomenorrhea patients (30–40 years) received CGGJD‐DS for 3 months, followed by a 2‐month follow‐up.
Mei Yu, Gui-Yan Liu, Wen-Xuan Zhou, Zhao-Hua Liu, Lian-Tao Li, Jin Chai   +5 more
wiley   +1 more source