Results 1 to 10 of about 146,504 (339)

Intracellular PAF catabolism by PAF acetylhydrolase counteracts continual PAF synthesiss⃞ [PDF]

Journal of Lipid Research, 2007
Stimulated inflammatory cells synthesize platelet-activating factor (PAF), but lysates of these cells show little enhancement in PAF synthase activity.
Jiawei Chen, Lili Yang, Jason M. Foulks, Andrew S. Weyrich, Gopal K. Marathe, Thomas M. McIntyre   +5 more
doaj   +3 more sources

Fish polar lipids retard atherosclerosis in rabbits by down-regulating PAF biosynthesis and up-regulating PAF catabolism [PDF]

Lipids in Health and Disease, 2011
BackgroundPlatelet activating factor (PAF) has been proposed as a key factor and initial trigger in atherosclerosis. Recently, a modulation of PAF metabolism by bioactive food constituents has been suggested.
C. Nasopoulou, A. Tsoupras, H. Karantonis, C. Demopoulos, I. Zabetakis   +4 more
semanticscholar   +2 more sources

Modulation of inflammatory platelet-activating factor (PAF) receptor by the acyl analogue of PAF

Journal of Lipid Research, 2018
Platelet-activating factor (PAF) is a potent inflammatory mediator that exerts its actions via the single PAF receptor (PAF-R). Cells that biosynthesize alkyl-PAF also make abundant amounts of the less potent PAF analogue acyl-PAF, which competes for PAF-
Vyala Hanumanthareddy Chaithra, Shancy Petsel Jacob, Chikkamenahalli Lakshminarayana Lakshmikanth, Mosale Seetharam Sumanth, Kandahalli Venkataranganayaka Abhilasha, Chu-Huang Chen, Anita Thyagarajan, Ravi P. Sahu, Jeffery Bryant Travers, Thomas M. McIntyre, Kempaiah Kemparaju, Gopal Kedihithlu Marathe   +11 more
doaj   +2 more sources

Platelet-activating factor induces ferroptosis by binding to ATF3 and inhibiting the SLC7A11/GPX4 axis to suppress the progression of endometrial carcinoma [PDF]

Biology Direct
Background Endometrial carcinoma (EC) is an aggressive gynecological malignancy with high recurrence rates and limited treatment options. Patients with EC exhibit elevated serum levels of lyso-platelet-activating factor (lyso-PAF), a biologically ...
Feifei Pan, Yuqing Qiu, Zhuojie Huang, Yanqin Zheng, Yun Chen, Yiming Song, Zhe-Sheng Chen, Lirong Guo, Jingyao Wang, Xiaojie Liu, Zixin Tao, Yaqiong Liu, Xingcui Xuan, Kunxiang Gong, Kun Shi   +14 more
doaj   +2 more sources

ASSOCIATION OF HEMATOCRIT-PLATELET INDEX AND HEMATOCRIT SHIFT WITH WARNING SIGNS AND HOSPITAL STAY IN DENGUE PATIENTS AT A TERTIARY CARE HOSPITAL

Pakistan Armed Forces Medical Journal, 2021
Objective: To determine the relationship between hematocrit, platelet count, warning signs and duration of hospitalization in indoor dengue patients. Study Design: Analytical, cross sectional study.
Muhammad Fahd Bin Haider, Humaira Zafar, Syed Zubair Hussain Shah, Mobaila Akram, Kamran Malik, Asif Niaz   +5 more
doaj   +1 more source

FREQUENCY AND RISK FACTORS FOR CHORONIC HCV IINFECTION:A COMMUNITY BASED STUDY

Pakistan Armed Forces Medical Journal, 2023
Objectives: It was a community based, cross sectional study undertaken to access the frequency of  HCV infection and to find out risk factor accociated with its spread..
Muhammad Tahir, Muhammad Babar Khan, Hassan Burair Abbas, Ghulam Mustafa   +3 more
doaj   +1 more source

Targeting the Platelet-Activating Factor Receptor (PAF-R): Antithrombotic and Anti-Atherosclerotic Nutrients

Nutrients, 2022
Platelet-activating factor (PAF) is a lipid mediator that interacts with its receptor (PAF-R) to carry out cell signalling. However, under certain conditions the binding of PAF to PAF-R leads to the activation of pro-inflammatory and prothrombotic ...
Rajendran Harishkumar, S. Hans, Janelle E. Stanton, A. Grabrucker, R. Lordan, I. Zabetakis   +5 more
semanticscholar   +1 more source

Micronutrients, Phytochemicals and Mediterranean Diet: A Potential Protective Role against COVID-19 through Modulation of PAF Actions and Metabolism

Nutrients, 2021
The new coronavirus disease 2019 (COVID-19) pandemic is an emerging situation with high rates of morbidity and mortality, in the pathophysiology of which inflammation and thrombosis are implicated.
P. Detopoulou, C. Demopoulos, Smaragdi Antonopoulou   +2 more
semanticscholar   +1 more source

The influence of chronic diseases and multimorbidity on entering paid employment among unemployed persons – a longitudinal register-based study

Scandinavian Journal of Work, Environment & Health, 2021
OBJECTIVES: This study aimed to investigate the influence of chronic diseases and multimorbidity on entering paid employment among unemployed persons. A secondary objective was to estimate the proportion of persons not entering paid employment that can ...
Berivan Yildiz, Alex Burdorf, Merel Schuring   +2 more
doaj   +1 more source

ANÁLISE COMPARATIVA ENTRE OS TRATAMENTOS DE CAR-T CELL E DE QUIMIOTERAPIA PARA A LEUCEMIA LINFOBLÁSTICA AGUDA DE CÉLULAS B EM CRIANÇAS

Hematology, Transfusion and Cell Therapy, 2023
Introdução: A Leucemia Linfoblástica Aguda (LLA) é uma neoplasia hematológica decorrente da transformação maligna dos precursores linfoides na medula óssea, com posterior proliferação e expansão para sangue periférico e sítios extramedulares. Para tentar
GR Zillig, PAF Oliveira
doaj   +1 more source