Results 91 to 100 of about 24,664,088 (323)

The relationship between obesity and plasminogen activator inhibitor 1 type plasma levels in patients with severe traumatic brain injury [PDF]

, 2016
Plasminogen activator inhibitor 1 type (PAI-1) is the principal inhibitor of fibrinolysis. The production of PAI-1 by adipose tissue could be an important contributor to the elevated PAI-1 plasma levels.
Towenna, C.A.
core  

Phocaeicola coprophilus‐Derived 6‐Methyluracil Attenuates Radiation‐Induced Intestinal Fibrosis by Suppressing the IDO1‐Kynurenine‐AHR Axis

Advanced Science, EarlyView.
IR‐induced dysbiosis depletes P. coprophilus and its metabolite 6‐methyluracil, leading to disinhibition of the IDO1‐Kyn‐AHR axis. This results in sustained fibroblast activation and collagen deposition, driving radiation induced intestinal fibrosis. ABSTRACT Therapeutic options for radiation‐induced intestinal fibrosis (RIF) remain limited. This study
Jiaxin Zhang, Zhen Wang, Shuang Li, Chao Luo, Han Li, Shengjie Ma, Pai Wang, Heshi Liu, Lijun Sun, Yue Yin, Weizhen Zhang, Quan Wang   +11 more
wiley   +1 more source

Dependence of plasminogen activator inhibitor-1 level on -675 4G/5G polymorphism in PAI-1 gene in patients with traumatic brain injury

Ukrainian Neurosurgical Journal, 2014
The purpose. To study relationship between plasminogen activator inhibitor-1 (PAI-1) level in plasma and -675 4G/5G polymorphism in the PAI-1 gene in patients with traumatic brain injury (TBI) in dynamics of treatment.Materials and methods ...
Oleksandr Potapov Jr, Oleksii Kmyta
doaj   +1 more source

Multimodal AI‐Driven Identification of Dehydrocostus Lactone as a Potent Renal Fibrosis Attenuator Targeting IQGAP1

Advanced Science, EarlyView.
Renal fibrosis, a hallmark of CKD, lacks effective treatments. Herein, we developed a multimodal AI model (TCM‐SPred) to identify anti‐fibrotic agents and found that dehydrocostus lactone (DCL) targets IQGAP1 to inhibit Wnt signaling, blocking the interaction between IQGAP1 and CCT3, demonstrating potent anti‐fibrotic activity in vitro and in vivo ...
Weijiang Lin, Wenzhuo Xu, Kang Liu, Ping Wang, Zhenzhen Zhu, Wenyu Lu, Zhe Zheng, Xiaoqian Peng, Xunkai Yin, Shulan Mei, An Pan, Jian Liu, Lihong Hu   +12 more
wiley   +1 more source

PAI-1 and TGF-β [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2006
Atherosclerosis is an extremely complex disease process in which genetic, lipid, cellular, and immunologic factors combine to determine the location, severity, and timing of lesion development and clinical events.1 With the current epidemic of obesity and the metabolic syndrome, additional factors are now recognized as contributors to the vascular ...
openaire   +1 more source

Pooled Analysis of Prognostic Impact of Urokinase-Type Plasminogen Activator and Its Inhibitor PAI-1 in 8377 Breast Cancer Patients [PDF]

, 2017
Background: Urokinase-type plasminogen activator (uPA) and its inhibitor (PAI-1) play essential roles in tumor invasion and metastasis. High levels of both uPA and PAI-1 are associated with poor prognosis in breast cancer patients.
Beex, Louk V. A. M., Bendahl, Pär-Ola, Blankenstein, Marinus A., Borstnar, Simona, Broët, Philippe, Brünner, Nils, Christensen, Ib Jarle, Cufer, Tanja, Daver, Alain, Daxenbichler, Günter, Duffy, Michael J., Duggan, Catherine, Eppenberger, Urs, Eppenberger-Castori, Serenella, Fernö, Mårten, Fiets, W. Edward, Foekens, John A., Harbeck, Nadia, Jänicke, Fritz, Kates, Ronald, Klijn, Jan G. M., Kueng, Willy, Lisboa, Björn W., Look, Maxime P., Magdelenat, Henri, Manders, Peggy, Martin, Pierre-Marie, Meijer-van Gelder, Marion E., O'Higgins, Niall, Peyrat, Jean-Philippe, Quillien, Véronique, Ricolleau, Gabriel, Romain, Sylvie, Schmitt, Manfred, Spyratos, Frédérique, Sweep, C. G. J. Fred, Thomssen, Christoph, Ulm, Kurt, van Putten, Wim L. J., Windbichler, Gudrun   +39 more
core  

Intelligent Soft Opto‐Magnetic Robot for Minimally Invasive Interventional Therapy

Advanced Science, EarlyView.
An intelligent soft opto‐magnetic (iSOM) robot is developed that integrates remote magnetic actuation, skin‐mimic tactile perception, and photothermal ablation in a near‐millimeter‐scale design. It enables precise intraluminal navigation and localized ablation while providing real‐time optical feedback to support safe and accurate minimally invasive ...
Jingjing Guo, Xiaoyan Guo, Jian Wei, Miaowen Jiang, Qifa Su, Xian Xia, Zhuozhou Li, Rong Cai, Jianguo Ma, Bo Fu, Ming Li, Jing Zhong, Lijun Xu, Xunming Ji   +13 more
wiley   +1 more source

Reduction of brain metastases in plasminogen activator inhibitor-1-deficient mice with transgenic ocular tumors [PDF]

, 2017
Plasminogen activator inhibitor-1 is known to play a paradoxical positive role in tumor angiogenesis, but its contribution to metastatic spread remains unclear.
Abitbol, M.M., Beermann, F., Bouquet, C., Foidart, J.M., Frau, E., Jost, M., Maillard, C.M., Masset, A.M., Mestdagt, M., Noël, A.C., Opolon, P.H., Perricaudet, M.J., Petitjean, M.M.   +12 more
core  

PAI-1 secretion of endometrial and endometriotic cells is Smad2/3- and ERK1/2-dependent and influences cell adhesion [PDF]

, 2016
In the endometrium transforming growth factor-betas (TGF-ßs) are involved mainly in menstruation and endometriosis. After binding of the ligands to the high-affinity receptors, TGF-ß receptors (TBR1 and TBR2), TGF-ßs activate Smad signaling to modulate ...
Konrad, Lutz, Mecha, Ezekiel, Omwandho, Charles O. A., Stammler, Angelika, Starzinski-Powitz, Anna, Sui, Cong, Tinneberg, Hans-Rudolf   +6 more
core   +1 more source

Photoacoustic Microscopy for Multiscale Biological System Visualization and Clinical Translation

Advanced Science, EarlyView.
Photoacoustic microscopy (PAM) is a powerful biomedical imaging tool renowned for its non‐invasiveness and high resolution. This review synthesizes recent technological advances and highlights their broad applications from cellular and organ‐level to whole‐animal imaging.
Tingting Wang, Jiali Chen, Liming Nie, Honghui Li   +3 more
wiley   +1 more source