On the Regulation of the Serine Protease t-PA and its Inhibitor PAI-1 in the Brain [PDF]
, 2010 The serine protease tissue-type plasminogen activator (t-PA) is the main fibrinolytic enzyme in the vascular system, and thus plays a critical role in the dissolution of thrombi.
Hultman, Karin
core
Frequency of factor II G20210A, factor V Leiden, MTHFR C677T and PAI-1 5G/4G polymorphism in patients with venous thromboembolism: Croatian case-control study [PDF]
, 2010 Introduction: Venous thromboembolic disease is one of the leading causes of morbidity and mortality in the developed world. Identification of hereditary factors of thrombophilia is contributing to a better understanding of the etiology and disease ...
Ana-Maria Simundic +7 more
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Polimorfismi dell'inibitore 1 dell'attivatore del plasminogeno e dell'enzima di conversione dell'angiotensina e rischio di complicanze nel diabete di tipo 1 e di tipo 2 [PDF]
, 2007 Background. Il sistema dell'attivatore del plasminogeno è ampiamente sotto il controllo del sistema renina-angiotensina: l'angiotensina II, sintetizzata dall’enzima di conversione dell’angiotensina (ACE), aumenta l'espressione e l'attività dell’inibitore
Storti, Eugenia
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Український журнал серцево-судинної хірургіїAim. To assess the efficacy of adding losartan to standard therapy in patients with ischemic heart disease (IHD) and polyvascular atherosclerosis following ischemic stroke as part of a multicomponent secondary prevention strategy over a 4-month treatment
Viktoriya-Svitlana M. Halich +2 more
doaj +1 more source
[Regulation of PAI-1 expression].
Postepy biochemii, 2009 PAI-1 (plasminogen activator inhibitor-1) is a member of plasminogen cascade with an inhibitory role in plasmin activation. Plasmin is a protease capable of acting on wide range of substrates and, together with metaloproteinases, is a main proteolytic enzyme. Except its role in plasminogen cascade, PAI-1 has an affinity to vitronectin and uPA/uPAR what
Paulina, Wyrzykowska, Aneta, Kasza
openaire +1 more source
Association of Blood Pressure and Fitness With Levels of Atherosclerotic Risk Markers Pre-Exercise and Post-exercise [PDF]
, 2017 Background: Physical fitness may attenuate the increased atherosclerotic risk in patients with systemic hypertension. We investigated the association of screening blood pressure (BP) and cardiorespiratory fitness with baseline levels and exercise-induced
Hong, Suzi +3 more
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Secondary thrombohemorrhagic complications in patients with severe traumatic brain injury depending on the -675 4G/5G polymorphism in the PAI-1 gene [PDF]
, 2014 Вторинні тромбогеморагічні ускладнення, що виникають у ранньому посттравматичному періоді, залишаються однією з основних причин загибелі хворих із тяжкою черепно-мозковою травмою. Метою нашого дослідження був аналіз виникнення та прогнозування розвитку
Kmyta, Oleksii Petrovych +5 more
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When a collective outcome triggers a rare individual event: a mode of metastatic process in a cell population [PDF]
, 2009 A model of early metastatic process is based on the role of the protein PAI-1, which at high enough extracellular concentration promotes the transition of cancer cells to a state prone to migration.
Barlovatz-Meimon, Georgia +6 more
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Functional Stability of Plasminogen Activator Inhibitor-1
The Scientific World Journal, 2014 Plasminogen activator inhibitor-1 (PAI-1) is the main inhibitor of plasminogen activators, such as tissue-type plasminogen activator (t-PA) and urokinase-type plasminogen activator (u-PA), and a major regulator of the fibrinolytic system.
Songul Yasar Yildiz +3 more
doaj +1 more source
PharmaceuticalsPlasminogen activation inhibitor-1 (PAI-1) plays a central role in thrombus formation leading to stroke; however, the contributions of PAI-1 to cellular damage in response to reactive oxygen species which are elevated during reperfusion are unknown ...
Safa, Charles E. Norton
doaj +1 more source