European Journal of Inflammation, 2018 Osteoporosis is a chronic multifactorial disease characterized by deterioration of bone mass and is vulnerable to bone fracture. Plasminogen activator inhibitor-1 (PAI-1) is an important molecule for maintenance of optimum bone mass.
An Wan, Daodong Liu
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High-intensity interval training modulates thrombotic susceptibility in metabolic syndrome: Attenuation of plasma PAI-1 and fibrinogen via ameliorated metabolic dysfunction [PDF]
Journal of Exercise & Organ Cross TalkMetabolic syndrome (MetS) elevates thrombotic risk through dysregulated coagulation factors, including plasminogen activator inhibitor-1 (PAI-1) and fibrinogen, driven by visceral adiposity and metabolic dysfunction.
Niyousha Ghazbani +6 more
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The prevalence of PAI-1 4G/5G gene variant in Serbian population [PDF]
Medicinski Glasnik Specijalne Bolnice za Bolesti Štitaste Žlezde i Bolesti Metabolizma "Zlatibor", 2013 Introduction: Plasminogen activator inhibitor 1 (PAI-1) has a major role in inhibition of firinolysis and normal haemostasis. The presence of the PAI-1 4G/4G genotype leads to increased expression of PAI-1.
Đorđević Valentina +6 more
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Relationship of adipokines with insulin sensitivity in African Americans. [PDF]
, 2011 INTRODUCTION: Cytokines produced by adipose tissue, including adiponectin, have been associated with metabolic abnormalities. The purpose of this study was to examine the relationship of insulin sensitivity measured by euglycemic hyperinsulinemic insulin
Deloach, Stephanie +4 more
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Urokinase-Type Plasminogen Activator System in Norm and in Life-Threatening Processes (Review)
Общая реаниматология, 2018 The multifunctional urokinase-type plasminogen activator system (uPA-system) includes serine proteinase — uPA or urokinase, its receptor (uPAR) and two inhibitors (PAI-1 and PAI-2).
Elena V. Kugaevskaya +3 more
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STUDY OF PROTHROMBOTIC MOLECULES IN TYPE 1 DIABETES MELLITUS CHILDREN
Revista de la Sociedad Argentina de Diabetes, 2019 Introduction: hyperglycemia contributes to molecular changes that alter hemostasis. Objectives: to determine molecules of a prothrombotic state in a child-juvenile population with type 1 diabetes (T1D), without clinical manifestation of vascular disease,
Adela Victoria Abregú +5 more
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Characterization of human mesenchymal stem cell secretome at early steps of adipocyte and osteoblast differentiation [PDF]
, 2008 International audienceBACKGROUND: It is well established that adipose tissue plays a key role in energy storage and release but is also a secretory organ and a source of stem cells.
Chiara Chiellini +8 more
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Inhibition of neutrophil apoptosis by PAI-1
American Journal of Physiology-Lung Cellular and Molecular Physiology, 2011 Increased circulating and tissue levels of plasminogen activator inhibitor 1 (PAI-1) are often present in severe inflammatory states associated with neutrophil activation and accumulation and correlate with poor clinical outcome from many of these conditions. The mechanisms by which PAI-1 contributes to inflammation have not been fully delineated.
Jaroslaw W, Zmijewski +5 more
openaire +3 more sources
HDAC1 inhibition by MS-275 in mesothelial cells limits cellular invasion and promotes MMT reversal [PDF]
, 2018 Peritoneal fibrosis is a pathological alteration of the peritoneal membrane occurring in a variety of conditions including peritoneal dialysis (PD), post-surgery adhesions and peritoneal metastases.
Battistelli, Cecilia +14 more
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Associations of circulating adipokines and coronary artery disease in young adults
Кардиоваскулярная терапия и профилактикаAim. To evaluate the associations of abdominal obesity (AO), adipokines and premature coronary artery disease (CAD) in young people for a deeper understanding of the pathogenesis of atherosclerotic diseases.Material and methods.
A. D. Khudiakova +6 more
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