Results 241 to 250 of about 119,296 (338)

Targeting FABP4 to Inhibit AGEs‐RAGE/NF‐κB Signalling Effectively Ameliorates Nucleus Pulposus Dysfunction and Angiogenesis in Obesity‐Related Intervertebral Disc Degeneration

open access: yesCell Proliferation, EarlyView.
Obesity promotes the progression of intervertebral disc degeneration (IVDD) through the mTORC1/FABP4 axis. Targeting FABP4 effectively ameliorates nucleus pulposus dysfunction and angiogenesis in obesity‐related IVDD. ABSTRACT Intervertebral disc degeneration (IVDD) is a primary contributor to low back pain, posing significant social and economic ...
Lin Han   +8 more
wiley   +1 more source

Palmitic acid alters enhancers/super-enhancers near inflammatory and efferocytosis-associated genes in human monocytes. [PDF]

open access: yesJ Lipid Res
Tanwar VS   +7 more
europepmc   +1 more source

Neural Organoids Protect Engineered Heart Tissues From Glucolipotoxicity by Transferring Versican in a Co‐Culture System

open access: yesCell Proliferation, EarlyView.
In this study, Bai et al. established a co‐culture system between neural organoids (NOs) and engineered heart tissues (EHTs) and demonstrated that NOs could secrete versican, which was absorbed by EHTs to ameliorate glucolipotoxicity. ABSTRACT Metabolic disorders could cause dysregulated glucose and lipid at the systemic level, but how inter‐tissue ...
Baochen Bai   +22 more
wiley   +1 more source

Palmitic Acid Accelerates Endothelial Cell Injury and Cardiovascular Dysfunction via Palmitoylation of PKM2. [PDF]

open access: yesAdv Sci (Weinh)
He Y   +10 more
europepmc   +1 more source

Enhanced mitochondrial respiration in peripheral blood mononuclear cells (PBMCs) from young children with overweight/obesity and insulin resistance

open access: yesEuropean Journal of Clinical Investigation, EarlyView.
We investigated measures of mitochondrial function in certain types of blood cells and metabolism in 65 children, 5–10 years old. Compared to children of normal weight (n = 20), children with overweight/obesity (n = 28) and especially those with insulin resistance (n = 17), differed in how their cells produced energy.
Eugenia Carvalho   +5 more
wiley   +1 more source

Palmitic acid and eicosapentaenoic acid supplementation in 3T3 adipocytes: impact on lipid storage and oxidative stress. [PDF]

open access: yesRedox Rep
Bakondi E   +7 more
europepmc   +1 more source

Crystal Structure of a 1:1 Complex of Palmitic acid and Nicotinamide

open access: bronze, 2006
M. Amai   +5 more
openalex   +2 more sources

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