Results 71 to 80 of about 5,096,341 (376)
Angewandte Chemie, EarlyView.This study introduces an integrated analytical and bioinformatics platform for high‐throughput tracing of lipid metabolism using bioorthogonal alkyne fatty acids and optimized LC‐MS workflow. Applied to human fibrosarcoma cells, the method traced fatty acid metabolism, revealing nuances in sphingolipid routing and metabolic bottlenecks, highlighting ...
Palina Nepachalovich +7 more
wiley +2 more sources
Effect of α-Bromo-palmitate on the Oxidation of Palmitic Acid by Rat Liver Cells
Journal of Biological Chemistry, 1971 Abstract Rat liver cell suspensions oxidized [1-14C]palmitic acid and [1-14C]palmitoyl-l-carnitine efficiently to CO2. Oxidation of tracer amounts of palmitate was inhibited by α-bromo-palmitate (2 x 10-4 m). The oxidation of tracer amounts of palmitoyl-l-carnitine was not affected.
F. D. Sauer, S. Mahadevan
openaire +3 more sources
Advanced Science, EarlyView.TRIM25‐mediated ubiquitination of INSIG1 serves as a key driver of lipid metabolism dysregulation in MASH progression. It identifies a novel small‐molecule inhibitor, C27H26N2O4S, which effectively inhibits TRIM25 activity, reducing lipid accumulation and inflammation.
Hao Zhang +8 more
wiley +1 more source
Lipids in Health and Disease, 2012 Background Fatty acid-induced insulin resistance and impaired glucose uptake activity in muscle cells are fundamental events in the development of type 2 diabetes and hyperglycemia.
Sawada Keisuke +5 more
doaj +1 more source
High-fat diet feeding and palmitic acid increase CRC growth in β2AR-dependent manner
Cell Death and Disease, 2019 Epidemiology studies indicate that consumption of high-fat diet (HFD) is directly associated with the development of colorectal cancer (CRC). However, the exact component in HFD and the mechanism underlying its effect on CRC growth remained unclear.
S. Fatima +12 more
semanticscholar +1 more source
Advanced Science, EarlyView.The study reveals that glutaminolysis in macrophages is inhibited under type 2 diabetes mellitus (T2DM) conditions, which impedes fracture healing by reducing bone morphogenetic protein 2 (BMP2) production through increased cytosine methylation on the promoter.
Jing Wang +12 more
wiley +1 more source
AcTion: Aceh Nutrition JournalThe fat intake of pregnant mothers, especially palmitic acid, which is one of the main components of palm oil, may affect the weight and fat mass of newborns. This study aimed to analyze the relationship between maternal palmitic acid intake and palmitic
Amira Ayu Aronasty +2 more
doaj +1 more source
Enzymatic Formation of Hexadecenoic Acid from Palmitic Acid
Agricultural and Biological Chemistry, 1975 Desaturation of palmitic acid was investigated in an enzyme system prepared from rat liver. 2-trans-Hexadecenoic acid as well as 9-cis-hexadecenoic acid (palmitoleic acid) were found to be formed as monoenoic acid in this system.
Masuo Nakano, Yasuhiko Fujino
openaire +3 more sources
Gelsolin's Protective Role in MASH through F‐Actin Regulation and P53 Degradation
Advanced Science, EarlyView.Gelsolin (GSN) maintains liver metabolic homeostasis by promoting MDM2‐mediated P53 degradation and inhibiting F‐actin/Yes‐associated protein (YAP) overactivation. Loss of GSN impairs P53 degradation, increases lipid deposition, and enhances YAP‐driven fibrosis and inflammation in metabolic‐associated steatohepatitis.
Yiwei Lu +9 more
wiley +1 more source
Journal of Lipid Research, 1971 In previous studies an apparent transfer of 14C-labeled fatty acid from phosphatidylcholine to phosphatidylethanolamine was observed in prelabeled human erythrocytes reincubated in fresh serum.
STEPHEN B. SHOHET
doaj