Results 71 to 80 of about 5,176,832 (349)

Palmitic Acid-Pluronic F127-Palmitic Acid Penta-Block Copolymer as a Novel Nanocarrier for Oral Delivery of Glipizide

The Turkish Journal of Pharmaceutical Sciences, 2018
The aim of the present study was to develop nanotechnology-based oral formulations of glipizide to enhance the bioavailability and eliminate the frequent oral administration of the conventional dosage form. Glipizide is an antidiabetic drug with a short biological half-life and limited oral bioavailability.
Vipan Kumar KAMBOJ, Prabhakar Kumar VERMA   +1 more
openaire   +2 more sources

Oxidative and endoplasmic reticulum stresses are involved in palmitic acid-induced H9c2 cell apoptosis

Bioscience Reports, 2019
Palmitic acid (PA) is the most common saturated long-chain fatty acid that causes damage to heart muscle cells. However, the molecular mechanism of PA toxicity in myocardial cells is not fully understood.
Lei Yang, Gaopeng Guan, L. Lei, Jianyun Liu, Lingling Cao, Xiangguo Wang   +5 more
semanticscholar   +1 more source

Skeletal Muscle HSF1 Alleviates Age‐Associated Sarcopenia and Mitochondrial Function Decline via SIRT3‐PGC1α Axis

Advanced Science, EarlyView.
Aged HSF1 muscle‐specific knockout mice show deteriorated muscle atrophy and metabolic dysfunction, while active HSF1 overexpression improves muscle function via activating SIRT3 to deacetylate both PGC1α1 and PGC1α4, which boosts mitochondrial function and muscle hypertrophy in a fiber‐type specific manner, and induces FNDC5/Irisin for tissue ...
Jun Zhang, Min Hu, Xia Wu, Mingwei Guo, Ying Ma, Jin Qiu, Siqi Wang, Yuxiang Cao, Yinzhao Zhong, Fangfang Chen, Yiwen Wang, Wei Wei, Yan Lu, Yong Zhang, Junjie Xiao, Zhenji Gan, Cheng Hu, Xinran Ma, Lingyan Xu   +18 more
wiley   +1 more source

High-fat diet feeding and palmitic acid increase CRC growth in β2AR-dependent manner

Cell Death and Disease, 2019
Epidemiology studies indicate that consumption of high-fat diet (HFD) is directly associated with the development of colorectal cancer (CRC). However, the exact component in HFD and the mechanism underlying its effect on CRC growth remained unclear.
S. Fatima, Xianjing Hu, Chunhua Huang, Weixiong Zhang, Jing Cai, Min Huang, Rui-Hong Gong, Minting Chen, Alan H. M. Ho, T. Su, Hoi Leong Xavier Wong, Z. Bian, H. Kwan   +12 more
semanticscholar   +1 more source

Conformable Device for Independent Measurements of Mucosal and Vascular Barriers in a Complex In Vitro Intestinal Model

Advanced Science, EarlyView.
Development of more complex in vitro models necessitates the development of improved monitoring approaches. This work demonstrates a novel conformable device capable of measuring the resistance of two cell barriers within a single model independently, a significant advantage over conventional trans‐epithelial/endothelial electrical resistance (TEER ...
Alexandra Elisabeth Wheeler, Sonja Blasche, Rob Bradley, Rachana Acharya, Sophie Oldroyd, David Bulmer, Kiran R. Patil, Róisín Meabh Owens   +7 more
wiley   +1 more source

Coadministration of linolenic acid and linoleic acid decreased lipotoxicity in cardiomyocytes.

فصلنامه دانشگاه علوم پزشکی جهرم, 2018
Background: Deleterious effects of lipid accumulation in non-adipose tissues are known as lipotoxicity. The prevalence of cardiovascular disease due to lipotoxicity has been dramatically increased worldwide.
Elham Zadeh Hashem, mina khodadadi, lachin mousavi   +2 more
doaj  

Intertidal Warfare: Synergistic Allelopathy Mediates Spatial Competition between Two Marine Calcareous‐Shelled Sessile Organisms

Advanced Science, EarlyView.
This study reveals a hidden chemical weapon among calcareous‐shelled sessile organisms in the intertidal zone: the barnacle Balanus albicostatus releases a synergistic blend of palmitic acid and 1‐palmitoyl‐sn‐glycero‐3‐phosphocholine as the allelochemical with the inhibitory activity against attachment of the mussel Vignadula atrata, which may mediate
Zhuo Li, Zixin Huo, Shanshan Yao, Xianmeng Liang, Yiran Zhao, Yanxin Wang, Shifeng Guo, Caihuan Ke, Pei Su, Danqing Feng   +9 more
wiley   +1 more source

Intestinal peroxisome proliferator‐activated receptor α‐fatty acid‐binding protein 1 axis modulates nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Abstract Background and Aims Peroxisome proliferator‐activated receptor α (PPARα) regulates fatty acid transport and catabolism in liver. However, the role of intestinal PPARα in lipid homeostasis is largely unknown. Here, intestinal PPARα was examined for its modulation of obesity and NASH. Approach and Results Intestinal PPARα was activated and fatty
Tingting Yan, Yuhong Luo, Nana Yan, Keisuke Hamada, Nan Zhao, Yangliu Xia, Ping Wang, Changdong Zhao, Dan Qi, Shoumei Yang, Lulu Sun, Jie Cai, Qiong Wang, Changtao Jiang, Oksana Gavrilova, Kristopher W. Krausz, Daxesh P. Patel, Xiaoting Yu, Xuan Wu, Haiping Hao, Weiwei Liu, Aijuan Qu, Frank J. Gonzalez   +22 more
wiley   +1 more source

Two-stage co-pyrolysis of Kraft lignin and palm oil mixture to biofuels: The role of lignin as a methylation agent for methyl ester formation

Fuel Processing Technology
In this work pyrolysis of palm oil and lignin has been investigated using a two-stage process at 550 °C, with a first step configuration of continuous condensation for vapors and separation of gases, and a second step with distillation of vapors ...
Matteo Borella, Alessandro A. Casazza, Guido Busca, Gabriella Garbarino   +3 more
doaj   +1 more source

Long-term effects of cis and trans monounsaturated (18:1) and saturated (16:0) fatty acids on the synthesis and secretion of apolipoprotein A-I- and apolipoprotein B-containing lipoproteins in HepG2 cells

Journal of Lipid Research, 2000
The objective of this study was to compare the long-term effects of oleic (cis 18:1), elaidic (trans 18:1), and palmitic (16:0) acids on hepatic lipoprotein production, using HepG2 cells as an experimental model.
Nassrin Dashti, Qing Feng, Frank A. Franklin   +2 more
doaj   +1 more source