Results 111 to 120 of about 39,498 (303)

Palmitoylation in cardiometabolic diseases: From molecular mechanisms to clinical implications

Pharmacological Research
Cardiometabolic diseases (CMDs), encompassing both cardiovascular diseases and metabolic syndromes, are among the leading causes of global morbidity and mortality.
Shenghui Feng, Yue Zhou, Linjuan Guo, Yan Liang, Wengen Zhu   +4 more
doaj   +1 more source

Role of Palmitoylation of Postsynaptic Proteins in Promoting Synaptic Plasticity

Frontiers in Molecular Neuroscience, 2019
Many postsynaptic proteins undergo palmitoylation, the reversible attachment of the fatty acid palmitate to cysteine residues, which influences trafficking, localization, and protein interaction dynamics.
Lucas Matt, Karam Kim, Dhrubajyoti Chowdhury, Johannes W. Hell   +3 more
doaj   +1 more source

Chemoproteomics reveals Toll-like receptor fatty acylation [PDF]

, 2014
Partial funding for Open Access provided by The Ohio State University Open Access Fund.Background: Palmitoylation is a 16-carbon lipid post-translational modification that increases protein hydrophobicity.
A Bafica, AF Roth, AI Su, AI Su, BA Merrick, Balyn W Zaro, BH Zheng, BR Martin, BR Martin, C Aicart-Ramos, C Ivaldi, C Salaun, C Wu, CB Lopez, CB Lopez, CT Tom, D Davda, D Rotin, E Latz, E Lorenz, F Sandor, G Charron, G Charron, GJ Freeman, H Kato, HC Hang, Howard C Hang, J Charollais, J Greaves, J Greaves, J Ren, Jacob S Yount, James L Chen, JC Hach, JL Hernandez, Joanne Turner, Jocelyn C Hach, JP Wilson, JS Yount, JS Yount, JS Yount, JS Yount, JS Yount, JS Yount, JS Yount, JS Yount, KJ Brandt, L Dowal, Larry S Schlesinger, M Fukata, M Muzio, M Scheffner, M Triantafilou, M Yamamoto, MA Imro, Matthew R Pratt, ME Linder, Murugesan VS Rajaram, Nicholas M Chesarino, NT Thuong, O Takeuchi, P Hollsberg, P Mill, R Barbalat, R Kang, R Tsutsumi, RM Steinman, RN Hannoush, S Blaskovic, S Borrello, S Kupzig, SC Henry, T Kawai, T Kawai, TR Hawn, Y Bulut, Y Fukata, Y Li, Y Webb, YY Yang, Z Jiang   +80 more
core   +2 more sources

Potential Role of S-Palmitoylation in Cancer Stem Cells of Lung Adenocarcinoma [PDF]

, 2021
Yitong Zhang, Fenglan Li, Kexin Fu, Xiqing Liu, I-Chia Lien, Hui Li   +5 more
openalex   +1 more source

ZDHHC5-mediated S-palmitoylation of FAK promotes its membrane localization and epithelial-mesenchymal transition in glioma

Cell Communication and Signaling
Abnormal activation of FAK is associated with tumor development and metastasis. Through interactions with other intracellular signalling molecules, FAK influences cytoskeletal remodelling, modulation of adhesion signalling, and activation of ...
Yang Wang, Na Shen, Yang Yang, Yuan Xia, Wenhao Zhang, Yu Lu, Zhicheng Wang, Ze Yang, Zhangjie Wang   +8 more
semanticscholar   +1 more source

Proteome‐Wide Analysis of Palmitoylated Proteins in Macrophages Reveals Novel Insights Into Early Immune Signaling

PROTEOMICS, EarlyView.
ABSTRACT Protein S‐palmitoylation, a reversible lipid modification, plays critical roles in regulating protein function and localization. However, its comprehensive role in the rapid reprogramming of macrophages during early immune responses remains incompletely understood.
Hyojung Kim, Jiraphorn Issara‐Amphorn, Sung Hwan Yoon, Anirban Banerjee, Aleksandra Nita‐Lazar   +4 more
wiley   +1 more source

The importance of claudin-7 palmitoylation on membrane subdomain localization and metastasis-promoting activities [PDF]

, 2015
Background: Claudin-7 (cld7), a tight junction (TJ) component, is also found basolaterally and in the cytoplasm. Basolaterally located cld7 is enriched in glycolipid-enriched membrane domains (GEM), where it associates with EpCAM (EpC).
Heiler, Sarah, Mu, Wei, Thuma, Florian, Zöller, Margot   +3 more
core   +1 more source

MAVS Cys508 palmitoylation promotes its aggregation on the mitochondrial outer membrane and antiviral innate immunity

Proceedings of the National Academy of Sciences of the United States of America
Significance This study established that S-palmitoylation catalyzed by ZDHHC7 plays an important role in RIG-I-like receptor signaling and antiviral innate immunity.
Yinong Liu, Dan Hou, Wenzhe Chen, Xuan Lu, Garrison Komaniecki, Yilai Xu, Tao Yu, Sophia M Zhang, M. Linder, Hening Lin   +9 more
semanticscholar   +1 more source

Pharmacological Inhibition of APT2 by Solasonine Promotes Ferroptosis Through Palmitoylation Modulation in Gallbladder Cancer

Phytotherapy Research, EarlyView.
Schematic illustration of SS‐induced ferroptosis through targeting APT2‐mediated STAT3 palmitoylation in GBC cells. ABSTRACT Gallbladder cancer (GBC), the most prevalent and lethal biliary tract malignancy, lacks effective therapeutic strategies. Solasonine (SS), a bioactive steroidal alkaloid derived from Solanum nigrum L, exhibits antitumor activity ...
Liu‐qing Shi, Jing‐wei Zhao, Jia‐yun Zhu, Cheng Zhao, Zi‐yi Yang, Li‐jia Pan, Ben Ma, Zheng‐yu Chen, Zi‐ying Wang, Chun‐jie Li, Shi‐lei Liu, Jia‐wei Mei, Ping Dong   +12 more
wiley   +1 more source

Amino acid residues 24-31 but not palmitoylation of cysteines 30 and 45 are required for membrane anchoring of glutamic acid decarboxylase, GAD65. [PDF]

, 1994
The smaller isoform of the GABA synthesizing enzyme glutamic acid decarboxylase, GAD65, is synthesized as a soluble protein that undergoes post-translational modification(s) in the NH2-terminal region to become anchored to the membrane of small synaptic ...
Baekkeskov, Steinunn, Shi, Y, Veit, B
core