Results 11 to 20 of about 9,478 (168)

Selectively Fluorinated PAMAM–Arginine Conjugates as Gene Delivery Vectors

Bioconjugate chemistry, 2023
Polyamidoamine (PAMAM) dendrimers are among the most studied cationic polymers as non-viral gene delivery vectors. However, an “ideal” PAMAM-based gene delivery vector is still missing due to the high manufacturing costs and non-negligible cytotoxicity ...
Carola Romani, P. Gagni, Mattia Sponchioni, A. Volonterio   +3 more
semanticscholar   +1 more source

Covalently grafting first-generation PAMAM dendrimers onto MXenes with self-adsorbed AuNPs for use as a functional nanoplatform for highly sensitive electrochemical biosensing of cTnT

Microsystems & Nanoengineering, 2022
2D MXene-Ti 3 C 2 T χ has demonstrated promising application prospects in various fields; however, it fails to function properly in biosensor setups due to restacking and anodic oxidation problems.
Xin Liu, Yonglian Qiu, Deming Jiang, Feng-Hai Li, Ying Gan, Yuxuan Zhu, Yuxiang Pan, H. Wan, Ping Wang   +8 more
semanticscholar   +1 more source

Second-Generation Polyamidoamine Dendrimer Conjugated with Oligopeptides Can Enhance Plasmid DNA Delivery In Vitro

Molecules, 2023
Poly(amidoamine) (PAMAM) dendrimers have attracted considerable attention in the field of gene therapy due to their flexibility in introducing different functional moieties and reduced toxicity at low generations.
Seongyeon Kim, Le Thi Thuy, Jeil Lee, Joon Sig Choi   +3 more
doaj   +1 more source

Effects of the surface charge of polyamidoamine dendrimers on cellular exocytosis and the exocytosis mechanism in multidrug-resistant breast cancer cells

Journal of Nanobiotechnology, 2021
Background Polyamidoamine (PAMAM) dendrimer applications have extended from tumor cells to multidrug-resistant tumor cells. However, their transportation in multidrug-resistant tumor cells remains unclear.
Jie Zhang, Mingjuan Li, Mingyue Wang, Hang Xu, Zhuoxiang Wang, Yue Li, Baoyue Ding, Jianqing Gao   +7 more
doaj   +1 more source

Multivalent Lactose–Ferrocene Conjugates Based on Poly (Amido Amine) Dendrimers and Gold Nanoparticles as Electrochemical Probes for Sensing Galectin-3

Nanomaterials, 2020
Galectin-3 is considered a cancer biomarker and bioindicator of fibrosis and cardiac remodeling and, therefore, it is desirable to develop convenient methods for its detection.
Manuel C. Martos-Maldonado, Indalecio Quesada-Soriano, Luis García-Fuentes, Antonio Vargas-Berenguel   +3 more
doaj   +1 more source

Diagnostic and therapeutic applications of smart nanocomposite dendrimers

Frontiers in Bioscience-Landmark, 2020
Dendrimers are three dimensional, multifunctional polymeric structures which are composed of a core and branches emanating from these structures, resembling a tree.
Vinay Kumar, Rakesh K. Sahoo, Trambak Basak, Tanjina Yasmin, Umesh Gupta, Amit K. Goyal   +5 more
doaj   +1 more source

β-Cyclodextrin and Oligoarginine Peptide-Based Dendrimer-Entrapped Gold Nanoparticles for Improving Drug Delivery to the Inner Ear

Frontiers in Bioengineering and Biotechnology, 2022
Here, we developed a safe and highly effective nanocarrier using β-cyclodextrin (β-CD) and oligoarginine peptide (Arg8)-modified dendrimer-entrapped gold nanoparticles (Au@CD-PAMAM-Arg8), with a diameter of 5 nm, for improved delivery of dexamethasone ...
Jia Luo, XueXin Lin, LiLing Li, JingQian Tan, Peng Li   +4 more
doaj   +1 more source

Engineered Fluorescent Carbon Dots and G4-G6 PAMAM Dendrimer Nanohybrids for Bioimaging and Gene Delivery.

Biomacromolecules, 2021
Carbon dots (CDs) and G4-G6 (polyamidoamine)PAMAM-NH2 dendrimers were self-assembled to produce CDs@PAMAM nanohybrids for transfection and bioimaging purposes.
Ivo Martins, H. Tomás, F. Lahoz, João Rodrigues   +3 more
semanticscholar   +1 more source

Dendritic Poly (amidoamine) Functionalized with Magnetic Nanoparticles as Sorbent for Simultaneous Magnetic Solid-Phase Extraction of Miconazole, Clotrimazole and Tioconazole Followed by Determination via HPLC-UV [PDF]

شیمی کاربردی روز, 2023
In this study, an attempt was made to synthesize a new sorbent based on the second generation of silica coated magnetic poly(amidoamine) (Fe3O4@SiO2@PAMAM) to improve the performance of magnetic solid phase extraction (MSPE) of some antifungal drugs ...
Mohsen Shirkhodayekashani, Sayed Mehdi Ghoreishi, Milad Ghani, Behrooz Maleki   +3 more
doaj   +1 more source

PAMAM and polyester dendrimers as favipiravir nanocarriers: a comparative study using DFT method

Journal of nanoparticle research, 2021
The electronic sensitivity and reactivity of polyamidoamine (PAMAM) and polyester dendrimers toward favipiravir (T705) were inspected using density functional theory method.
Sekineh Bazyari-Delavar, Farideh Badalkhani-Khamseh, A. Ebrahim-Habibi, N. Hadipour   +3 more
semanticscholar   +1 more source