Results 61 to 70 of about 9,478 (168)

Advances in Elemene Nanodelivery Systems: From Material Design to Disease Treatment

Rare Metals, EarlyView.
ABSTRACT Elemene (ELE) is a bioactive sesquiterpenoid extracted from traditional Chinese herbs, demonstrating broad‐spectrum antitumor, anti‐inflammatory, and analgesic properties with significant therapeutic potential. However, its clinical utility is constrained by inherent physicochemical limitations, including volatility and hydrophobicity, which ...
Xiao Wang, Jiatong Lin, Yi Peng, Zehua Wu, Yingying Liu, Wei Duan, Qiaolin Wei, Jia‐Wei Shen, Jiang‐Xing Chen, Yong Guo   +9 more
wiley   +1 more source

Ligand‐specific tuning of CLEC10A signalling strength and dendritic cell responses through engagement of different GalNAc‐containing glycan structures

The FEBS Journal, EarlyView.
The authors investigated the effects of various glycan ligands for CLEC10A, a lectin receptor expressed on dendritic cells (DCs). Monocyte‐derived DCs were stimulated with glycan‐conjugated dendrimers in combination with the TLR1/2 ligand Pam3CysK4, and responses were investigated at the mRNA and protein level.
Nadia L. van der Meijs, Remi Hatinguais, Mike de Kok, R. J. Eveline Li, Tesfay M. Godefa, Victor L. J. L. Thijssen, Yvette van Kooyk, Sandra J. van Vliet   +7 more
wiley   +1 more source

Potential Targets and Biomarkers of Radionuclide Therapy in Breast Cancer

Cancer Innovation, Volume 5, Issue 1, February 2026.
Potential biomarkers for the development of targeted radionuclide therapy that can be employed in the treatment of breast cancer have been summarised in the review. They include receptor markers of ER, PR and HER2, as well as other markers of Trop2, PD‐1, EGFR, GRPR and PSMA.
Yujing Tan, Cheng Zeng, Jiani Wang, Fei Ma   +3 more
wiley   +1 more source

A study on the hemocompatibility of dendronized chitosan derivatives in red blood cells

Drug Design, Development and Therapy, 2015
Yanfang Zhou,1,* Jiemei Li,1,* Fang Lu,1 Junjie Deng,2 Jiahua Zhang,1 Peijie Fang,1 Xinsheng Peng,1 Shu-Feng Zhou3 1Guangdong Medical Universtity, Dongguan, Guangdong, People’s Republic of China; 2Department of Materials Science and Engineering ...
Zhou YF, Li JM, Lu F, Deng JJ, Zhang JH, Fang PJ, Peng XS, Zhou SF   +7 more
doaj  

Urea Biosensor Based on a Field‐Effect Capacitor Modified With a Stacked Weak Polyelectrolyte/Enzyme Bilayer

Electrochemical Science Advances, Volume 6, Issue 1, February 2026.
ABSTRACT Urea is formed from the metabolism of proteins and used as a biomarker for diagnosing and monitoring various medical conditions. In this work, a urea biosensor based on an electrolyte‐insulator‐semiconductor capacitor (EISCAP) modified with a stacked polyelectrolyte polyallylamine hydrochloride (PAH)/urease bilayer prepared by the layer‐by ...
Astghik S. Tsokolakyan, Vardan A. Hayrapetyan, Derenik K. Petrosyan, Melanie Welden, Heiko Iken, Michael J. Schöning, Mkrtich A. Yeranosyan, Arshak Poghossian   +7 more
wiley   +1 more source

In vitro cytotoxicity of the ternary PAMAM G3–pyridoxal–biotin bioconjugate

International Journal of Nanomedicine, 2013
Łukasz Uram, Magdalena Szuster, Krzysztof Gargasz, Aleksandra Filipowicz, Elżbieta Wałajtys-Rode, Stanisław Wołowiec Cosmetology Department, University of Information Technology and Management in Rzeszów, Rzeszów, Poland Abstract: A third ...
Uram Ł, Szuster M, Gargasz K, Filipowicz A, Wałajtys-Rode E, Wołowiec S   +5 more
doaj  

Designing of fucosylated dendrimers as a biocompatible carrier for the targeted delivery of chrysin to human lung cancer cells

Next Materials
Dendrimers, a polymeric macromolecule, have been explored for improving the solubility of water-insoluble drugs, and PAMAM is the most explored dendrimer in nanomedicine. But amine-terminated PAMAM dendrimers confer toxicity to healthy cells.
Divya Bharti Rai, Raghu Solanki, Sunita Patel, Deep Pooja, Hitesh Kulhari   +4 more
doaj   +1 more source

Multicomponent Conjugates of Anticancer Drugs and Monoclonal Antibody with PAMAM Dendrimers to Increase Efficacy of HER-2 Positive Breast Cancer Therapy

Pharmaceutical Research, 2019
Conjugation of nanocarriers with antibodies that bind to specific membrane receptors that are overexpressed in cancer cells enables targeted delivery.
M. Marcinkowska, M. Stańczyk, A. Janaszewska, Ewelina Sobierajska, A. Chworos, B. Klajnert-Maculewicz   +5 more
semanticscholar   +1 more source

Reconfigurable Nucleic Acid Nanoparticles with Therapeutic RNAi Responses to Intracellular Disease Markers

Advanced Functional Materials, Volume 36, Issue 5, 15 January 2026.
Many known diseases arise from dysregulated gene expression, and differentially expressed genes can serve as biomarkers to distinguish diseased cells from healthy tissues. In this study, reconfigurable nucleic acid nanoparticles (recNANPs) are introduced that can detect overexpressed cancer biomarkers and subsequently release RNAi inducers to silence ...
Yelixza I. Avila, Anh Ha, Morgan R. Chandler, Nathalia Leal Santos, Taejin Kim, Hannah S. Newton, Marina A. Dobrovolskaia, Kirill A. Afonin   +7 more
wiley   +1 more source

Effect of Cross-Linking on the Mechanical and Thermal Properties of Poly(amidoamine) Dendrimer/Poly(vinyl alcohol) Hybrid Membranes for CO2 Separation

Membranes, 2014
Poly(amidoamine) (PAMAM) dendrimers were incorporated into cross-linked poly(vinyl alcohol) (PVA) matrix to improve carbon dioxide (CO2) separation performance at elevated pressures.
Shuhong Duan, Teruhiko Kai, Takashi Saito, Kota Yamazaki, Kenichi Ikeda   +4 more
doaj   +1 more source