Results 201 to 210 of about 36,882 (246)
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Environmental Technology & Innovation, 2018
This research is a first-time investigation into the use of poly (amidoamine) (PAMAM) dendrimers (Generation 4: G 4 ) as well-designed, highly-branched macromolecules with abundant active amine groups for the adsorptive removal of nickel (Ni 2 + ) and ...
Roya Ebrahimi +6 more
semanticscholar +1 more source
This research is a first-time investigation into the use of poly (amidoamine) (PAMAM) dendrimers (Generation 4: G 4 ) as well-designed, highly-branched macromolecules with abundant active amine groups for the adsorptive removal of nickel (Ni 2 + ) and ...
Roya Ebrahimi +6 more
semanticscholar +1 more source
Mechanism of PAMAM Dendrimers Internalization in Hippocampal Neurons
Molecular Pharmaceutics, 2016Polyamidoamine (PAMAM) dendrimers are hyperbranched macromolecules which have been described as one of the most promising drug nanocarrier systems. A key process to understand is their cellular internalization mechanism because of its direct influence on their intracellular distribution, association with organelles, entry kinetics, and cargo release ...
Felipe, Vidal +5 more
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DNA Assisted Self-Assembly of PAMAM Dendrimers
The Journal of Physical Chemistry B, 2014We report DNA assisted self-assembly of polyamidoamine (PAMAM) dendrimers using all atom Molecular Dynamics (MD) simulations and present a molecular level picture of a DNA-linked PAMAM dendrimer nanocluster, which was first experimentally reported by Choi et al. (Nano Lett., 2004, 4, 391-397). We have used single stranded DNA (ssDNA) to direct the self-
Mandal, Taraknath +2 more
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PAMAM Dendrimers as Delivery Agents for Antisense Oligonucleotides
Pharmaceutical Research, 1999To investigate the potential use of PAMAM dendrimers for the delivery of antisense oligonucleotides into cells under conditions that mimic the in vivo environment.We used HeLa cells stably transfected with plasmid pLuc/705 which has a luciferase gene interrupted by a human beta-globin intron mutated at nucleotide 705, thus causing incorrect splicing ...
H, Yoo, P, Sazani, R L, Juliano
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PAMAM Dendrimers for siRNA Delivery: Computational and Experimental Insights
Chemistry – A European Journal, 2010AbstractShort double‐stranded RNAs, which are known as short interfering RNA (siRNA), can be used to specifically down‐regulate the expression of the targeted gene in a process known as RNA interference (RNAi). However, the success of gene silencing applications based on the use of synthetic siRNA critically depends on efficient intracellular delivery.
Pavan GM +8 more
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Enhanced biocompatibility of PAMAM dendrimers benefiting from tuning their surface charges.
Materials Science and Engineering C: Materials for Biological Applications, 2018The surface charge of dendrimers is one of the key factors that determine their use in nanomedicine. Generation 5 poly(amido amine) dendrimers (G5 PAMAM) encapsulating with fluorescein sodium were employed to study the method to tune surface charge ...
Yanshuai Cui +6 more
semanticscholar +1 more source
Supramolecular mimetic peroxidase based on hemin and PAMAM dendrimers
Chem. Commun., 2008An acid-base interaction between hemin and PAMAM dendrimers affords supramolecular non-covalent peroxidase systems whose catalytic activity is enhanced after spontaneous electrostatic self-assembling onto a solid surface.
CASTRICIANO MA +4 more
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Self‐assembled PAMAM dendrimer films
Advanced Materials, 1997Self‐assembly of starburst dendrimers into closely packed cells (see the optical micrograph in the Figure) is reported for generation 9.5 polyamidoamine (PAMAM) dendrimers solvent‐cast onto hydrophilic silicon substrates. It is shown that on the microscopic scale the cells are made up of a complex network of intertwined dendritic microfibrils ...
Simon A. Evenson, Jas Pal S. Badyal
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Influence of PAMAM dendrimers on the human insulin
AIP Conference Proceedings, 2015Dendrimers are specific class of polymeric macromolecules with wide spectrum of properties. One of the promising activities of dendrimers involves inhibition of protein fibril formation. Aggregation and fibrillation of insulin occurs in insulin-dependent diabetic patients after repeated administration, due to these processes being very easily triggered
Olga Nowacka +3 more
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DNA-Templated Covalent Coupling of G4 PAMAM Dendrimers
Journal of the American Chemical Society, 2010Generation-4 polyamidoamine (PAMAM) dendrimers were surface-functionalized with azides or alkynes and conjugated to one DNA strand. DNA-controlled self-assembly of alternating azide and alkyne dendrimers on a DNA template enabled the coupling of the dendrimers by the azide-alkyne "click" reaction to form covalently coupled dimers, trimers, and ...
Liu, Huajie +5 more
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