Results 81 to 90 of about 50,328 (300)

Development of Highly pH-Sensitive Hybrid Membranes by Simultaneous Electrospinning of Amphiphilic Nanofibers Reinforced with Graphene Oxide

Journal of Functional Biomaterials, 2019
: Nanofibrous-based pH sensors have shown promise in a wide range of industrial and medical applications due to their fast response time and good mechanical properties.
Mohsen Gorji, Ali Sadeghianmaryan, Hossein Rajabinejad, Saman Nasherolahkam, Xiongbiao Chen   +4 more
doaj   +1 more source

Tissue Damage in Rheumatoid Arthritis Is Genetically Linked to Low Peptidylglycine Alpha‐Amidating Monooxygenase Activity in Synovial Fibroblasts

Arthritis &Rheumatology, EarlyView.
Objective Both susceptibility to, and severity of, rheumatoid arthritis (RA) is associated with the rs26232 C allele. Our primary aim was to identify the biologic mechanism underlying this association. Methods Expression of surrounding genes was compared among rs26232 genotypes.
Kevin J. Sheridan, Emma R. Dorris, Maria Inês Pimenta, Jemma Falkov, Matthew Fisher, Sam Pledger, Hector Devey, Munitta Muthana, Denis C. Shields, Richard E. Mains, Betty A. Eipper, Christopher D. Buckley, Anthony G. Wilson   +12 more
wiley   +1 more source

Hepatocyte Toll‐like receptors contribute to the hepcidin inflammatory response to pathogens and pathogen‐derived ligands

HemaSphere
Iron restriction is a critical pathomechanism underlying the Anemia of Inflammation and an innate immune response limiting the replication of extracellular pathogens.
Katharina Bonitz, Silvia Colucci, Ruiyue Qiu, Sandro Altamura, Richard Sparla, Katja Mudder, Stefan Zimmermann, Matthias W. Hentze, Martina U. Muckenthaler, Oriana Marques   +9 more
doaj   +1 more source

Alarmins, inflammasomes and immunity

Biomedical Journal, 2012
The elaboration of an effective immune response against pathogenic microbes such as viruses, intracellular bacteria or protozoan parasites relies on the recognition of microbial products called pathogen-associated molecular patterns (PAMPs) by pattern ...
Najwane Saïd-Sadier, David M Ojcius
doaj   +1 more source

The PAMP c-di-AMP Is Essential for Listeria monocytogenes Growth in Rich but Not Minimal Media due to a Toxic Increase in (p)ppGpp [PDF]

, 2015
Aaron T. Whiteley, Alex J. Pollock, Daniel A. Portnoy   +2 more
openalex   +1 more source

RORγt‐APCs: The New Masters of Oral Tolerance

Barrier Immunity, EarlyView.
ABSTRACT Oral tolerance is defined by the hypo‐responsiveness of our body to fed antigens, and its failure can lead to immune‐mediated diseases, such as allergy, chronic inflammation and autoimmune diseases. Decades of research have demonstrated that antigen‐presenting cells (APCs) promote oral tolerance by inducing regulatory T cells (Tregs) and/or ...
Thierry Gauthier, WanJun Chen
wiley   +1 more source

Macroautophagy during innate immune activation

Frontiers in Cellular and Infection Microbiology, 2011
Innate immune activation is initiated by recognition of pathogen associated molecular patterns (PAMPs). Delivery of PAMPs to their respective receptors, regulation of receptor activity and effector functions downstream from these receptors, which ...
Christian eMunz
doaj   +1 more source

Quality control, preparation process optimizing and anti-inflammatory effects of Premna Puberula Pamp. Pectin

, 2022
Kaiqi Liu, Yingying Guo, Xiaojing Chen, Jufeng Duan, Bei Li, Ming Liu, Chen Lin, Minglun Li, Yibin Feng, Hongliang Li, Xuanbin Wang   +10 more
openalex   +1 more source

Novel Organelle‐Based Intracellular Immunity With Mechanistic and Therapeutic Implications

Barrier Immunity, EarlyView.
A conceptual framework illustrating how PAMPs/DAMPs initiate barrier, innate, adaptive, and intracellular immune responses, with organelle‐based intracellular immunity serving as a central integrator linking metabolism, inflammatory signaling, and therapeutic interventions to restore immune homeostasis.
Keman Xu, Shih‐Yu Hung, Fatma Saaoud, Ying Shao, Yifan Lu, Juanjuan Liu, Bo Yuan, Haiyan Xiang, Hong Wang, Xiaofeng Yang   +9 more
wiley   +1 more source

Cardiac remodelling in the era of the recommended four pillars heart failure medical therapy

ESC Heart Failure, Volume 12, Issue 2, Page 1029-1044, April 2025.
Abstract Cardiac remodelling is a key determinant of worse cardiovascular outcome in patients with heart failure (HF) and reduced ejection fraction (HFrEF). It affects both the left ventricle (LV) structure and function as well as the left atrium (LA) and the right ventricle (RV).
Giada Colombo, Tor Biering‐Sorensen, Joao P. Ferreira, Carlo Mario Lombardi, Andrea Bonelli, Andrea Garascia, Marco Metra, Riccardo M. Inciardi   +7 more
wiley   +1 more source