Results 61 to 70 of about 52,994 (295)

A Keratinocyte‐Mast Cell NF‐κB2/CXCL2/IL‐6 Amplification Loop Enhances Cutaneous Antifungal Defense Against C. albicans

open access: yesAdvanced Science, EarlyView.
ABSTRACT Mast cells (MCs), key innate immune sentinels at the host–environment interface, serve as primary responders to invading pathogens. However, their specific contribution to host defense against cutaneous Candida albicans (C. albicans) infection and their synergy with other immune and non‐immune cells remain poorly understood. Here, we show that
Yan Yuan   +12 more
wiley   +1 more source

Various forms of tissue damage and danger signals following hematopoietic stem cell transplantation

open access: yesFrontiers in Immunology, 2015
Hematopoietic stem cell transplantation (HSCT) is the most potent curative therapy for many malignant and non-malignant disorders. Unfortunately, a major complication of HSCT is graft-versus-host disease (GVHD), which is mediated by tissue damage ...
Abdulraouf eRamadan, Sophie ePaczesny
doaj   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

open access: yesAdvanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li   +7 more
wiley   +1 more source

PAMPs and DAMPs: signal 0s that spur autophagy and immunity.

open access: yes, 2021
Pathogen-associated molecular pattern molecules (PAMPs) are derived from microorganisms and recognized by pattern recognition receptor (PRR)-bearing cells of the innate immune system as well as many epithelial cells.
Tang, Daolin   +4 more
core   +1 more source

Engineering Oncolytic Virus‐Armed Macrophages for Enhanced Cancer Immunotherapy

open access: yesAdvanced Science, EarlyView.
ZIFOA‐M is engineered by conjugating oncolytic adenovirus‐loaded ZIF‐8 nanoparticles onto macrophage surfaces via bioorthogonal chemistry. Upon tumor infiltration, the platform releases OA to downregulate CD47/CD24 on tumor cells, restoring macrophage phagocytosis.
Jilong Wang   +10 more
wiley   +1 more source

Type I interferon drives dendritic cell apoptosis via multiple BH3-only proteins following activation by PolyIC in vivo.

open access: yesPLoS ONE, 2011
BackgroundDC are activated by pathogen-associated molecular patterns (PAMPs), and this is pivotal for the induction of adaptive immune responses. Thereafter, the clearance of activated DC is crucial to prevent immune pathology.
Silvia A Fuertes Marraco   +12 more
doaj   +1 more source

Stabilizing a Zn Anode by an Ionic Amphiphilic Copolymer Electrolyte Additive for Long-Life Aqueous Zn-Ion Batteries

open access: yesBatteries, 2022
The rampant growth of zinc dendrites and severe uncontrollable reactions have largely limited the industrialization of aqueous Zn-ion batteries. Electrolyte additive engineering was found to be a facile yet effective strategy in addressing these issues ...
Yu-E Liu, Xin Wang
doaj   +1 more source

Synergistic Dual Slip‐Link Toughening of a Water‐Rich Double Network Hydrogel Combining Slide‐Ring and Highly Entangled Networks

open access: yesAdvanced Science, EarlyView.
Two distinct slip‐link mechanisms – the slide‐ring pulley effect and highly entangled chains – are combined in a water‐rich double network hydrogel, achieving synergistic toughening, near‐complete reversibility, and exceptional friction tear resistance at >$>$91 wt.% water.
Subhankar Mandal   +5 more
wiley   +1 more source

Structure and Morphology of PVDF-G-PAMPS Membrane

open access: yes, 2011
A proton exchange membrane of blended poly (acrylamido-2- methylpropane sulfonic acid) (PAMPS) grafted onto modified poly (vinylidene fluoride) (PVDF) membrane (PVDF-g-PAMPS) was prepared.
Sheng Li An, Gui Bao Guo
core   +1 more source

Method for Studying the Effect of Gene Silencing on Bacterial Infection-induced ERK1/2 Signaling in Bone-marrow Derived Macrophages

open access: yesBio-Protocol, 2018
Macrophages are highly phagocytic cells that utilize various pathogen recognition receptors (PRRs) to recognize pathogen-associated molecular patterns (PAMPs).
Gaurav Kumar, Subhash Arya, Amit Tuli
doaj   +1 more source

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