Results 91 to 100 of about 811,378 (409)

neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas.

Proceedings of the National Academy of Sciences of the United States of America, 2000
In the mammalian pancreas, the endocrine cell types of the islets of Langerhans, including the alpha-, beta-, delta-, and pancreatic polypeptide cells as well as the exocrine cells, derive from foregut endodermal progenitors.
G. Gradwohl, A. Dierich, M. Lemeur, F. Guillemot   +3 more
semanticscholar   +1 more source

Simultaneous Pancreas-Kidney and Pancreas Transplantation [PDF]

Journal of the American Society of Nephrology, 2001
The discovery of insulin in 1922 changed the treatment of type 1 diabetes mellitus (DM) forever. Insulin was the first effective therapy for type 1 DM; however, its success engendered a terrible paradox for patients with this disease.
Hans W. Sollinger, Cathy Werwinski, Yolanda T. Becker, Bryan N. Becker, Marilyn Groshek, John D. Pirsch, Jon S. Odorico   +6 more
openaire   +3 more sources

Predictors of distant metastasis on exploration in patients with potentially resectable pancreatic cancer

BMC Gastroenterology, 2018
Background Patients with potentially resectable pancreatic ductal adenocarcinoma (PDAC) are frequently found to be unresectable on exploration due to small distant metastasis.
Xinchun Liu, Yue Fu, Qiuyang Chen, Junli Wu, Wentao Gao, Kuirong Jiang, Yi Miao, Jishu Wei   +7 more
doaj   +1 more source

Pancreas segmentation with probabilistic map guided bi-directional recurrent UNet [PDF]

Physics in Medicine & Biology, 66(11), 115010 (2021), 2019
Pancreas segmentation in medical imaging data is of great significance for clinical pancreas diagnostics and treatment. However, the large population variations in the pancreas shape and volume cause enormous segmentation difficulties, even for state-of-the-art algorithms utilizing fully-convolutional neural networks (FCNs).
arxiv   +1 more source

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

Pancreas Transplantation

Renal Failure, 1995
Vascularized pancreas transplantation has assumed an increasing role in the treatment of diabetes mellitus. Through 1994, over 6000 pancreas transplants had been performed worldwide, with over 80% being combined pancreas-kidney transplants. Overall 1-year patient survival exceeds 90% and graft survival (complete insulin independence) exceeds 70 ...
R J, Stratta, R J, Taylor, J L, Larsen, K, Cushing   +3 more
openaire   +3 more sources

Cell‐free and extracellular vesicle microRNAs with clinical utility for solid tumors

Molecular Oncology, EarlyView.
Cell‐free microRNAs (cfmiRs) are small‐RNA circulating molecules detectable in almost all body biofluids. Innovative technologies have improved the application of cfmiRs to oncology, with a focus on clinical needs for different solid tumors, but with emphasis on diagnosis, prognosis, cancer recurrence, as well as treatment monitoring.
Yoshinori Hayashi, Janelle‐Cheri Millen, Romela Irene Ramos, Jennifer A. Linehan, Timothy G. Wilson, Dave S. B. Hoon, Matias A. Bustos   +6 more
wiley   +1 more source

Identification and management of pancreas divisum

Expert Review of Gastroenterology & Hepatology, 2019
Introduction: Pancreas divisum is the most common congenital malformation of the pancreas with the majority asymptomatic. The etiological role, pathogenesis, clinical significance and management of pancreas divisum in pancreatic disease has not been ...
A. Gutta, E. Fogel, S. Sherman
semanticscholar   +1 more source

Effect of partial pancreatectomy on diabetic status in BALB/c mice. [PDF]

, 1999
Pancreatic regeneration after pancreatectomy has been well documented in animal models. However, the phenomenon of pancreatic regeneration in diabetes has not been exploited as yet.
Bhonde, RR, Hardikar, AA, Karandikar, MS
core   +1 more source

Trends in 5-year cancer survival disparities by race and ethnicity in the US between 2002–2006 and 2015–2019

Scientific Reports
Racial and ethnic disparities persist in cancer survival rates across the United States, despite overall improvements. This comprehensive analysis examines trends in 5-year relative survival rates from 2002–2006 to 2015–2019 for major cancer types ...
Chongfa Chen, Lingdi Yin, Chunhui Lu, Guangfu Wang, Zhenyu Li, Feihu Sun, Huijuan Wang, Chenchen Li, Shangnan Dai, Nan Lv, Jishu Wei, Zipeng Lu, Feng Guo, Min Tu, Bin Xiao, Chunhua Xi, Kai Zhang, Qiang Li, Junli Wu, Wentao Gao, Xu Feng, Kuirong Jiang, Yi Miao   +22 more
doaj   +1 more source