Results 91 to 100 of about 974,159 (389)

Efficacy of second-line treatment for gemcitabine-refractory unresectable pancreatic cancer in a real-world setting

BMC Cancer
Background This study aimed to compare the benefits and identify the best second-line treatment regimen for gemcitabine-refractory unresectable pancreatic cancers.
Qianqian Wang, Nan Lv, Dong Xu, Yang Wu, Junli Wu, Wentao Gao, Jishu Wei, Bin Xiao, Min Tu, Kuirong Jiang   +9 more
doaj   +1 more source

Coagulation parameters for the differential diagnosis of pancreatic cancer in the early stage: a retrospective study

European Journal of Medical Research, 2023
Background In recent years, conventional coagulation (CC) and thromboelastography (TEG) parameters have been reported to be closely related to the progression of pancreatic cancer (PC).
Li Jiaao, Ge Wanli, Zhang Kai, Guo Feng, Peng Yunpeng   +4 more
doaj   +1 more source

Identification and management of pancreas divisum

Expert Review of Gastroenterology & Hepatology, 2019
Introduction: Pancreas divisum is the most common congenital malformation of the pancreas with the majority asymptomatic. The etiological role, pathogenesis, clinical significance and management of pancreas divisum in pancreatic disease has not been ...
A. Gutta, E. Fogel, S. Sherman
semanticscholar   +1 more source

A unified model for Duchenne muscular dystrophy gene involvement in cancer: context‐dependent tumour suppression and oncogenicity

FEBS Open Bio, EarlyView.
We propose a context‐dependent model where the Duchenne muscular dystrophy (DMD) gene acts as a tumour suppressor in aggressive tumours and as an oncogene in less aggressive ones. We propose this model as a unified framework to explain the opposing survival associations with DMD expression and to guide experimental exploration of the dual role of DMD ...
Lee Machado, Leanne Jones, Sonika Divakar, Michael Naidoo, Karen Anthony   +4 more
wiley   +1 more source

Solid-pseudopapillary tumor of the pancreas: A single center experience [PDF]

, 2016
open6noAim of this study was to review the institutional experience of solid-pseudopapillary tumors of the pancreas with particular attention to the problems of preoperative diagnosis and treatment.
Alberto Fantin, Cosimo Sperti, Enrico Dalla Bona, Gioia Pozza, Michele Valmasoni, Valentina Beltrame   +5 more
core   +3 more sources

Short‐term actions of epigalocatechin‐3‐gallate in the liver: a mechanistic insight into hypoglycemic and potential toxic effects

FEBS Open Bio, EarlyView.
Epigallocatechin‐3‐gallate (EGCG) acutely inhibited gluconeogenesis and enhanced glycolysis, glycogenolysis, and fatty acid oxidation in perfused rat livers. Mechanistic assays revealed mitochondrial uncoupling, inhibition of pyruvate carboxylation and glucose‐6‐phosphatase, shift of NADH/NAD+ ratios toward oxidation, and loss of membrane integrity ...
Carla Indianara Bonetti, Bruna Lopes Correia, Francielle Cristina Nakamura Manicardi, Nairana Mithieli de Queiroz Eskuarek Melo, Vanesa de Oliveira Pateis, Jurandir Fernando Comar, Anacharis Babeto de Sá‐Nakanishi, Adelar Bracht, Lívia Bracht   +8 more
wiley   +1 more source

Trends in 5-year cancer survival disparities by race and ethnicity in the US between 2002–2006 and 2015–2019

Scientific Reports
Racial and ethnic disparities persist in cancer survival rates across the United States, despite overall improvements. This comprehensive analysis examines trends in 5-year relative survival rates from 2002–2006 to 2015–2019 for major cancer types ...
Chongfa Chen, Lingdi Yin, Chunhui Lu, Guangfu Wang, Zhenyu Li, Feihu Sun, Huijuan Wang, Chenchen Li, Shangnan Dai, Nan Lv, Jishu Wei, Zipeng Lu, Feng Guo, Min Tu, Bin Xiao, Chunhua Xi, Kai Zhang, Qiang Li, Junli Wu, Wentao Gao, Xu Feng, Kuirong Jiang, Yi Miao   +22 more
doaj   +1 more source

Molecular Mechanisms of Amylin Turnover, Misfolding and Toxicity in the Pancreas [PDF]

, 2022
Diti Chatterjee Bhowmick, Zhanar Kudaibergenova, Lydia Burnett, Aleksandar Jeremić   +3 more
openalex   +1 more source

Pancreatic adaptive responses in alcohol abuse: Role of the unfolded protein response. [PDF]

, 2015
The majority of those who drink excessive amounts of alcohol do not develop pancreatic disease. One overarching hypothesis is that alcohol abuse requires additional risk factors, either environmental or genetic, for disease to occur.
Lugea, Aurelia, Pandol, Stephen J, Waldron, Richard T   +2 more
core   +1 more source

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source