Results 11 to 20 of about 5,109,346 (334)
Clinical Chemistry, 2013 Pancreatic cancer (PC) is the 10th most common cancer type and the fourth leading cause of cancer-related deaths. The vast majority of PCs are pancreatic adenocarcinomas. Diagnosis of small tumors at an early stage or dysplastic premalignant lesions that
C. Chrystoja +5 more
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PARP inhibitors in pancreatic cancer: molecular mechanisms and clinical applications
Molecular Cancer, 2020 Pancreatic cancer is a highly lethal disease with a poor prognosis, and existing therapies offer only limited effectiveness. Mutation gene sequencing has shown several gene associations that may account for its carcinogenesis, revealing a promising ...
Heng Zhu +10 more
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JAMA, 2021 Importance Pancreatic ductal adenocarcinoma (PDAC) is a relatively uncommon cancer, with approximately 60 430 new diagnoses expected in 2021 in the US. The incidence of PDAC is increasing by 0.5% to 1.0% per year, and it is projected to become the second-
Wungki Park, A. Chawla, E. O’Reilly
semanticscholar +3 more sources
The Lancet, 2020 Pancreatic cancer is a highly fatal disease with a 5-year survival rate of approximately 10% in the USA, and it is becoming an increasingly common cause of cancer mortality. Risk factors for developing pancreatic cancer include family history, obesity, type 2 diabetes, and tobacco use.
J. Mizrahi +3 more
semanticscholar +5 more sources
European Journal of Surgical Oncology, 2023 The need for a common education and training track in surgical oncology across Europe has been emphasized. ESSO provides several hands-on courses for skills training and face-to-face discussions. The core curriculum provides a framework for the overall theoretical requirements in surgical oncology. The UEMS/EBSQ fellowship exam is designed to test core
Kjetil Søreide +4 more
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Gastroenterology, 2023 Pancreatic cancer usually results in poor survival with limited options for treatment, as most affected individuals present with advanced disease. Early detection of pre-invasive pancreatic neoplasia and identifying molecular therapeutic targets provide ...
E. Stoffel, R. Brand, M. Goggins
semanticscholar +1 more source
Journal of Hematology & Oncology, 2022 Many types of human cells self-destruct to maintain biological homeostasis and defend the body against pathogenic substances. This process, called regulated cell death (RCD), is important for various biological activities, including the clearance of ...
Xuhui Tong +8 more
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Nature Reviews Disease Primers, 2016 Pancreatic cancer is a major cause of cancer-associated mortality, with a dismal overall prognosis that has remained virtually unchanged for many decades. Currently, prevention or early diagnosis at a curable stage is exceedingly difficult; patients rarely exhibit symptoms and tumours do not display sensitive and specific markers to aid detection ...
Kleeff, J +10 more
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World Journal of Surgical Oncology, 2021 Background Glutamine-fructose-6-phosphate transaminase 1 (GFPT1) is the first rate-limiting enzyme of the hexosamine biosynthesis pathway (HBP), which plays a pivotal role in the progression of pancreatic ductal adenocarcinoma (PDAC).
Yitao Gong +11 more
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Oncogenesis, 2022 Pancreatic ductal adenocarcinoma (PDAC) is a well-known lethal and heterogeneous disease. Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like (APOBEC) is an important mutagenic driver that has seldom been investigated in PDAC. Therefore, this
Yunzhen Qian +13 more
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