Results 21 to 30 of about 641,720 (354)
Hypermutation In Pancreatic Cancer [PDF]
Gastroenterology, 2017 Pancreatic cancer is molecularly diverse, with few effective therapies. Increased mutation burden and defective DNA repair are associated with response to immune checkpoint inhibitors in several other cancer types. We interrogated 385 pancreatic cancer genomes to define hypermutation and its causes. Mutational signatures inferring defects in DNA repair Ivana Cataldo, Andrew V. Biankin, Anirban Maitra, Anthony J. Gill, Anthony J. Gill, Anthony J. Gill, Andreia V. Pinho, Nikolajs Zeps, Richard D. Schulick, Marc D. Jones, Marc D. Jones, Oliver Hofmann, Timothy J. C. Bruxner, Felicity Newell, Felicity Newell, Skye McKay, John V. Pearson, John V. Pearson, Margaret A. Tempero, Jaswinder S. Samra, Jaswinder S. Samra, Conrad Leonard, Conrad Leonard, Ivon Harliwong, Marc Giry-Laterriere, Matthew J. Anderson, Andrew Barbour, Roberto Salvia, Fraser Duthie, Nicola Waddell, Nicola Waddell, Amanda Mawson, Oliver Holmes, Oliver Holmes, Peter J. Wilson, Ilse Rooman, Suzanne Manning, J. Lynn Fink, Giampaolo Tortora, Nick Waddell, Craig Nourse, Craig Nourse, Robert Grützmann, Angelika N. Christ, Nigel B. Jamieson, Nigel B. Jamieson, Karin A. Oien, C. Ross Carter, Jeremy L. Humphris, Venessa T. Chin, Christopher J. Scarlett, Christopher J. Scarlett, Peter Bailey, Peter Bailey, Christine A. Iacobuzio-Donahue, Rita T. Lawlor, Janet Graham, Janet Graham, Marina Pajic, Marina Pajic, Jennifer P. Morton, Ronald S Mead, Karin S. Kassahn, Karin S. Kassahn, David Miller, David Miller, Mark Pinese, Lorraine A. Chantrill, Lorraine A. Chantrill, David K. Chang, Angela Chou, Angela Chou, Stephen H. Kazakoff, Stephen H. Kazakoff, Owen J. Sansom, Krishna Epari, Nam Q. Nguyen, Ann-Marie Patch, Ann-Marie Patch, Elizabeth A. Musgrove, Elizabeth A. Musgrove, Elizabeth A. Musgrove, Andrew Stone, Christopher L. Wolfgang, Christian Pilarsky, Ehsan Nourbakhsh, Katia Nones, Katia Nones, Borislav Rusev, Neil D. Merrett, Jianmin Wu, Vincenzo Corbo, Senel Idrisoglu, Colin J. McKay, Ralph H. Hruban, Sean M. Grimmond, Sean M. Grimmond, Qinying Xu, Qinying Xu, Euan J. Dickson, Christopher W. Toon, Mark J. Cowley, Mark J. Cowley, Amber L. Johns, Adnan Nagrial, James R. Eshleman, James G. Kench, James G. Kench, James G. Kench, Aldo Scarpa, Jane Hair, Scott Wood, Scott Wood, Michael C.J. Quinn, Michael C.J. Quinn, Richard A. Morgan +115 moreopenaire +5 more sourcesExome-wide association study of pancreatic cancer risk [PDF]
, 2018 We conducted a case-control exome-wide association study to discover germline variants in coding regions that affect risk for pancreatic cancer, combining data from 5 studies. We analyzed exome and genome sequencing data from 437 patients with pancreatic Biankin, Andrew, Borgida, Ayelet, Cleary, Sean, Connor, Ashton A., Cook, Natalie, Denroche, Robert E., Gallinger, Steven, Grant, Robert C., Grimmond, Sean M., Klein, Alison P., Lemire, Mathieu, Moore, Malcolm, Peterson, Gloria, Roberts, Nicholas J., Smith, Alyssa L., Stein, Lincoln, Virtanen, Carl, Wilson, Julie M., Zogopolous, George +18 morecore +1 more sourceRole of tumor mutation burden-related signatures in the prognosis and immune microenvironment of pancreatic ductal adenocarcinoma
Cancer Cell International, 2021 Background High tumor mutation burden (TMB) has gradually become a sensitive biomarker for predicting the response to immunotherapy in many cancers, including lung, bladder and head and neck cancers.Rong Tang, Xiaomeng Liu, Wei Wang, Jie Hua, Jin Xu, Chen Liang, Qingcai Meng, Jiang Liu, Bo Zhang, Xianjun Yu, Si Shi +10 moredoaj +1 more sourceMucins and Pancreatic Cancer [PDF]
Cancers, 2010 Pancreatic cancer is characterized by an often dramatic outcome (five year survival < 5%) related to a late diagnosis and a lack of efficient therapy. Therefore, clinicians desperately need new biomarkers and new therapeutic tools to develop new efficient therapies. Mucins belong to an ever increasing family of O-glycoproteins.Jonckheere, Nicolas, Skrypek, Nicolas, van Seuningen, Isabelle +2 moreopenaire +5 more sourcesA novel protein isoform of the RON tyrosine kinase receptor transforms human pancreatic duct epithelial cells. [PDF]
, 2016 The MST1R gene is overexpressed in pancreatic cancer producing elevated levels of the RON tyrosine kinase receptor protein. While mutations in MST1R are rare, alternative splice variants have been previously reported in epithelial cancers.Babicky, M, Chakedis, J, French, R, Holman, P, Howard, H, Jaquish, D, Lam, R, Lowy, AM, Miyamoto, J, Mose, E, Walterscheid, Z +10 morecore +2 more sourcesFrom the Immune Profile to the Immunoscore: Signatures for Improving Postsurgical Prognostic Prediction of Pancreatic Neuroendocrine Tumors
Frontiers in Immunology, 2021 ObjectiveImmune infiltration plays an important role in tumor development and progression and shows promising prognostic value in numerous tumors. In this study, we aimed to identify the role of immune infiltration in pancreatic neuroendocrine tumors ...Miaoyan Wei, Miaoyan Wei, Miaoyan Wei, Miaoyan Wei, Miaoyan Wei, Jin Xu, Jin Xu, Jin Xu, Jin Xu, Jin Xu, Jie Hua, Jie Hua, Jie Hua, Jie Hua, Jie Hua, Qingcai Meng, Qingcai Meng, Qingcai Meng, Qingcai Meng, Qingcai Meng, Chen Liang, Chen Liang, Chen Liang, Chen Liang, Chen Liang, Jiang Liu, Jiang Liu, Jiang Liu, Jiang Liu, Jiang Liu, Bo Zhang, Bo Zhang, Bo Zhang, Bo Zhang, Bo Zhang, Wei Wang, Wei Wang, Wei Wang, Wei Wang, Wei Wang, Xianjun Yu, Xianjun Yu, Xianjun Yu, Xianjun Yu, Xianjun Yu, Si Shi, Si Shi, Si Shi, Si Shi, Si Shi +49 moredoaj +1 more sourcePancreatic cancer cachexia: a review of mechanisms and therapeutics. [PDF]
, 2014 Over the last decade, we have gained new insight into the pathophysiology of cachexia associated with pancreatic cancer. Unfortunately, its treatment is complex and remains a challenge.Andrew Eugene Hendifar, Andrew Eugene Hendifar, Carlyn Rose Tan, Laith eJamil, Nick eNissen, Patrick eYaffee, Richard eTuli, Simon eLo, Stephen J Pandol +8 morecore +2 more sourcesHypoxia-reprogrammed regulatory group 2 innate lymphoid cells promote immunosuppression in pancreatic cancer
EBioMedicine, 2022 Summary: Background: Previously, we uncovered a patient subgroup with highly malignant pancreatic cancer with serum markers CEA+/CA125+/CA19-9 ≥ 1000 U/mL (triple-positive, TP).Longyun Ye, Kaizhou Jin, Zhenyu Liao, Zhiwen Xiao, Huaxiang Xu, Xuan Lin, Hao Li, Tianjiao Li, Wuhu Zhang, Xuan Han, Wenquan Wang, Heli Gao, Liang Liu, Weiding Wu, Xianjun Yu +14 moredoaj Combined resection of the transpancreatic common hepatic artery preserving the gastric arterial arcade without arterial reconstruction in hepatopancreatoduodenectomy: a case report
Surgical Case Reports, 2018 Background Surgeons sometimes must plan pancreatoduodenectomy (PD) for patients with a variant common hepatic artery (CHA) branching from the superior mesenteric artery (SMA) penetrating the pancreatic parenchyma, known as a transpancreatic CHA (tp-CHA). Takashi Miyata, Yusuke Yamamoto, Teiichi Sugiura, Yukiyasu Okamura, Takaaki Ito, Ryo Ashida, Sunao Uemura, Yoshiyasu Kato, Katsuhisa Ohgi, Atsushi Kohga, Tsuneyuki Uchida, Shusei Sano, Katsuhiko Uesaka +12 moredoaj +1 more sourceCrosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives
Molecular Cancer, 2021 Cancer-associated fibroblasts (CAFs), a stromal cell population with cell-of-origin, phenotypic and functional heterogeneity, are the most essential components of the tumor microenvironment (TME).Xiaoqi Mao, Jin Xu, Wei Wang, Chen Liang, Jie Hua, Jiang Liu, Bo Zhang, Qingcai Meng, Xianjun Yu, Si Shi +9 moredoaj +1 more source
