Chronic Pancreatitis and Pancreatic Cancer [PDF]
Gastroenterology, 2014 <b><i>Background:</i></b> Pancreatic cancer (PC) is one of the most lethal diseases with an incidence rate almost equal to the rate of mortality. Chronic pancreatitis (CP) is a common chronic inflammatory disease of unknown etiology that affects the pancreas.
Bai-Rong Li, Liang-Hao Hu, Zhao-Shen Li
openaire +6 more sources
Pancreatic Cancer in Chronic Pancreatitis [PDF]
Indian Journal of Surgical Oncology, 2015 Data exists to indicate a definite association between chronic pancreatitis and pancreatic cancer. The strength of this association varies between various causes of pancreatitis, with hereditary and tropical pancreatitis more likely to result in malignancy. Pathogenesis may involve genetic factors, diabetes, smoking and alcohol consumption.
Puneet Dhar, S. Kalghatgi, Vivek Saraf
openaire +3 more sources
The global, regional, and national burden of pancreatic cancer and its attributable risk factors in 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. [PDF]
, 2019 BACKGROUND: Worldwide, both the incidence and death rates of pancreatic cancer are increasing. Evaluation of pancreatic cancer burden and its global, regional, and national patterns is crucial to policy making and better resource allocation for ...
GBD 2017 Pancreatic Cancer Collaborators
core +2 more sources
Loss of TRAIL-receptors is a recurrent feature in pancreatic cancer and determines the prognosis of patients with no nodal metastasis after surgery. [PDF]
, 2013 Agonistic antibodies targeting TRAIL-receptors 1 and 2 (TRAIL-R1 and TRAIL-R2) are being developed as a novel therapeutic approach in cancer therapy including pancreatic cancer.
Bader, Dominik C. +8 more
core +13 more sources
The role of necroptosis in cancer biology and therapy
Molecular Cancer, 2019 Apoptosis resistance is to a large extent a major obstacle leading to chemotherapy failure during cancer treatment. Bypassing the apoptotic pathway to induce cancer cell death is considered to be a promising approach to overcoming this problem ...
Yitao Gong +10 more
doaj +1 more source
PARP inhibitors in pancreatic cancer: molecular mechanisms and clinical applications
Molecular Cancer, 2020 Pancreatic cancer is a highly lethal disease with a poor prognosis, and existing therapies offer only limited effectiveness. Mutation gene sequencing has shown several gene associations that may account for its carcinogenesis, revealing a promising ...
Heng Zhu +10 more
doaj +1 more source
The Lancet, 2020 Pancreatic cancer is a highly fatal disease with a 5-year survival rate of approximately 10% in the USA, and it is becoming an increasingly common cause of cancer mortality. Risk factors for developing pancreatic cancer include family history, obesity, type 2 diabetes, and tobacco use.
Jonathan D, Mizrahi +3 more
openaire +4 more sources
Targeting apoptosis signaling in pancreatic cancer [PDF]
, 2011 The ability to escape apoptosis or programmed cell death is a hallmark of human cancers, for example pancreatic cancer. This can promote tumorigenesis, since too little cell death by apoptosis disturbs tissue homeostasis.
Fulda, Simone
core +2 more sources
DeformableFormer: Classification of Endoscopic Ultrasound Guided Fine Needle Biopsy in Pancreatic Diseases [PDF]
arXiv, 2023 Endoscopic Ultrasound-Fine Needle Aspiration (EUS-FNA) is used to examine pancreatic cancer. EUS-FNA is an examination using EUS to insert a thin needle into the tumor and collect pancreatic tissue fragments. Then collected pancreatic tissue fragments are then stained to classify whether they are pancreatic cancer.
arxiv
Epigallocatechin-3-Gallate (EGCG) Suppresses Pancreatic Cancer Cell Growth, Invasion, and Migration partly through the Inhibition of Akt Pathway and Epithelial-Mesenchymal Transition: Enhanced Efficacy when Combined with Gemcitabine. [PDF]
, 2019 Most pancreatic cancers are usually diagnosed at an advanced stage when they have already metastasized. Epigallocatechin-3-gallate (EGCG), a major polyphenolic constituent of green tea, has been shown to reduce pancreatic cancer growth, but its effect on
Hackman, Robert M +4 more
core +2 more sources