Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Proteomics Approach Highlights Early Changes in Human Fibroblasts-Pancreatic Ductal Adenocarcinoma Cells Crosstalk [PDF]
, 2022 Verena Damiani +10 more
openalex +1 more source
Evaluation and treatment decision of pancreatic tumors by use of MRI with MRCP imaging [PDF]
, 2009 Background: Pancreatic cancer is one of the most malignant tumors. Symptoms are usually nonspecific and insidious such that the cancer is advanced by the time of diagnosis.
Turowska, Aldona +2 more
core
Marked expansion of exocrine and endocrine pancreas with incretin therapy in humans with increased exocrine pancreas dysplasia and the potential for glucagon-producing neuroendocrine tumors. [PDF]
, 2013 Controversy exists regarding the potential regenerative influences of incretin therapy on pancreatic β-cells versus possible adverse pancreatic proliferative effects.
Atkinson, Mark +5 more
core +2 more sources
Interplay between RNA‐protein interactions and RNA structures in gene regulation
FEBS Open Bio, EarlyView.Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko +2 more
wiley +1 more source
Pancreas divisum. Correlation between anatomical abnormalities and bile precipitation in the gallbladder in seven patients [PDF]
, 2016 Pancreas divisum is a genetic defect associated with recurrent acute pancreatitis due to insufficient drainage of the accessory pancreatic duct. Seven young patients diagnosed with pancreatic divisum and thickening of the gallbladder bile as shown on ...
AL MANSOUR, Monir +12 more
core +1 more source
Bioprinting Organs—Science or Fiction?—A Review From Students to Students
Advanced Healthcare Materials, EarlyView.Bioprinting artificial organs has the potential to revolutionize the medical field. This is a comprehensive review of the bioprinting workflow delving into the latest advancements in bioinks, materials and bioprinting techniques, exploring the critical stages of tissue maturation and functionality.
Nicoletta Murenu +18 more
wiley +1 more source
Genetic study of congenital bile-duct dilatation identifies de novo and inherited variants in functionally related genes [PDF]
, 2016 Background: Congenital dilatation of the bile-duct (CDD) is a rare, mostly sporadic, disorder that results in bile retention with severe associated complications. CDD affects mainly Asians.
Campbell, Desmond +12 more
core +1 more source
Advanced Healthcare Materials, EarlyView.Metallofullerenol Sc3N@C80(OH)18 demonstrates strong radioprotective properties as a scavenger of both short‐ and long‐lived radicals. The study reveals protection of human erythrocytes from γ‐radiation–induced biochemical damage via post‐irradiation removal of primary and secondary reactive oxidants, supported by pulse radiolysis kinetics.
Jacek Grebowski +6 more
wiley +1 more source
Wasit Journal for Pure Sciences, 2022 Due to the importance of the pancreas and its secretion in the digestive tract of birds, this study was carried out to compare the histological structure of the exocrine pancreas in ducks and turkeys, these birds differ in their habitats and ...
Atyaf Hussein, Ali Fayadh Bargooth
doaj +1 more source