Results 91 to 100 of about 439,784 (298)

Homozygosity for a variant in SLC10A2 and infancy onset severe fat‐soluble vitamin deficiency due to bile acid malabsorption

JPGN Reports, EarlyView.
Abstract We present a case of a young female patient with persistent and severe fat‐soluble vitamin deficiency since infancy. Despite extensive investigations during childhood, the underlying cause remained elusive. The patient was generally asymptomatic while receiving continuous vitamin subsidy.
Christine Rungoe, Stefan Stender, Nawar Dalila, Emil D. Bartels, Christian Jakobsen   +4 more
wiley   +1 more source

Long-term endogenous acetylcholine deficiency potentiates pulmonary inflammation in a murine model of elastase-induced emphysema

Scientific Reports, 2021
Acetylcholine (ACh), the neurotransmitter of the cholinergic system, regulates inflammation in several diseases including pulmonary diseases. ACh is also involved in a non-neuronal mechanism that modulates the innate immune response. Because inflammation
Rosana Banzato, Nathalia M. Pinheiro, Clarice R. Olivo, Fernanda R. Santana, Fernanda D. T. Q. S. Lopes, Luciana C. Caperuto, Niels O. Câmara, Milton A. Martins, Iolanda F. L. C. Tibério, Marco Antônio M. Prado, Vânia F. Prado, Carla M. Prado   +11 more
doaj   +1 more source

Origin and characterization of cyclodepsipeptides: Comprehensive structural approaches with focus on mass spectrometry analysis of alkali‐cationized molecular species

Mass Spectrometry Reviews, EarlyView.
Abstract Cyclodepsipeptides (CDPs) represent a huge family of chemically and structurally diverse molecules with a wide ability for molecular interactions. CDPs are cyclic peptide‐related natural products made up of both proteinogenic and nonproteinogenic amino acids linked by amide and ester bonds.
Sophie Liuu, Annelaure Damont, Alain Perret, Olivier Firmesse, François Becher, Gwenaëlle Lavison‐Bompard, Amandine Hueber, Amina S. Woods, Ekaterina Darii, François Fenaille, Jean‐Claude Tabet   +10 more
wiley   +1 more source

Carbohydrate structure of human pancreatic elastase 1 [PDF]

Biochemical Journal, 1991
Human pancreatic elastase 1 (E1) is a glycoprotein containing two potential N-glycosylation sites, one of which carries a carbohydrate moiety [Wendorf, Geyer, Sziegoleit & Linder (1989) FEBS Lett. 249, 275-278]. In order to study its glycosylation, glycoprotein isolated from post-mortem pancreas tissue of 75 donors was digested with trypsin ...
A Sziegoleit, P Wendorf, Rudolf Geyer, Dietmar Linder   +3 more
openaire   +3 more sources

Exocrine Pancreatic Insufficiency, as Assessed by Fecal Elastase-1 Levels, in Diabetic Patients: An Estimate of Prevalence in Prospective Studies

, 2014
Objective: To assess the prevalence of pancreatic exocrine insufficiency (PEI) inpatients with diabetes mellitus (DM). Design: Meta-analysis of prospective, observational studies that used fecal elastase-1 estimation to determine PEI in patients with DM.
A. Andriulli, A. Ippolito, V. Festa, M. R. Valvano, A. Merla, F. Bossa, G. Niro, G. Napolitano, L. Benini, I. Vantini   +9 more
semanticscholar   +1 more source

Micronutrient deficiencies after pancreatico‐duodenectomy: A narrative review of the literature and recommendations for clinical practice

Nutrition in Clinical Practice, EarlyView.
Abstract Micronutrient uptake is impaired after pancreatico‐duodenectomy (PD) because of malabsorption, reduced absorptive capacity, and poor oral intake. Biochemical depletion is reported in cohort studies, but deficiency states are predominantly reported in case reports, making it difficult to assess occurrence rates.
Mary E. Phillips, Callum Livingstone, Adam E. Frampton, Kathryn H. Hart   +3 more
wiley   +1 more source

Epithelial-to-Mesenchymal Transition in Pancreatic Ductal Adenocarcinoma and Pancreatic Tumor Cell Lines: The Role of Neutrophils and Neutrophil-Derived Elastase

Clinical and Developmental Immunology, 2012
Pancreatic ductal adenocarcinoma (PDAC) is frequently associated with fibrosis and a prominent inflammatory infiltrate in the desmoplastic stroma. Moreover, in PDAC, an epithelial-to-mesenchymal transition (EMT) is observed.
Thomas Große-Steffen, Thomas Giese, Nathalia Giese, Thomas Longerich, Peter Schirmacher, G. Maria Hänsch, Matthias M. Gaida   +6 more
doaj   +1 more source

Does pancreatic elastase-1 in stools predict steatorrhea in type 1 diabetes?

Diabetes Care, 2006
Areduction of exocrine pancreas function frequently occurs in type 1 diabetes (1), and its detection has been made easy by measurement of fecal pancreatic elastase-1 (PE-1) (2,3).
F. Cavalot, K. Bonomo, E. Fiora, E. Bacillo, P. Salacone, Massimo Chirio, E. Gaia, M. Trovati   +7 more
semanticscholar   +1 more source

Differences in the Fecal Metabolome of Autoimmune Pancreatitis Patients

United European Gastroenterology Journal, EarlyView.
ABSTRACT Background Chronic pancreatitis is a risk factor for pancreatic cancer. Autoimmune pancreatitis is a unique form of chronic pancreatitis that is primarily characterized by its immune mediate etiology, clinically resembling pancreatic cancer, yet uniquely responsive to steroid treatment.
Vladyslav Dovhalyuk, Fan Yang, Sara Nikolic, Miroslav Vujasinovic, J.‐Matthias Löhr, Daniel Globisch   +5 more
wiley   +1 more source

Emerging pharmacological treatments to prevent abdominal aortic aneurysm growth and rupture [PDF]

, 2015
Abdominal aortic aneurysm (AAA) is a local expansion of the abdominal aorta wall caused by a complex multifactorial maladaptive vascular remodeling. Despite recent advances in the management of cardiovascular diseases, there currently is no established ...
Fraga-Silva, Rodrigo, Stergiopulos, Nikolaos, Trachet, Bram   +2 more
core   +2 more sources