Serine Proteases: an Ab Initio Molecular Dynamics Study [PDF]
arXiv, 1999 In serine proteases (SP's), the H-bond between His-57 and Asp-102, and that between Gly-193 and the transition state intermediate play a crucial role for enzymatic function. To shed light on the nature of these interactions, we have carried out ab initio molecular dynamics simulations on complexes representing adducts between the reaction intermediate ...
arxiv
[18F]Fluorothymidine Uptake in the Porcine Pancreatic Elastase-Induced Model of Abdominal Aortic Aneurysm. [PDF]
J Imaging, 2021 Gandhi R +3 more
europepmc +1 more source
Sepsis is a syndrome with hyperactivity of TH17-like innate immunity and hypoactivity of adaptive immunity [PDF]
arXiv, 2013 Currently, there are two major theories for the pathogenesis of sepsis: hyperimmune and hypoimmune. Hyperimmune theory suggests that cytokine storm causes the symptoms of sepsis. On the contrary, hypoimmune theory suggests that immunosuppression causes the manifestations of sepsis.
arxiv
Experimental Physiology, EarlyView.Abstract Circulating cell‐free DNA (cfDNA), circulating tumour DNA (ctDNA) and inflammatory cytokines have prognostic and predictive value in oncology. However, the effects of acute exercise on cfDNA levels are unknown. Here, we explore the kinetics of cfDNA, ctDNA and cytokines upon an incremental exercise test in a pilot cohort of cancer patients ...
Elmo W. I. Neuberger +10 more
wiley +1 more source
The primary structure of porcine pancreatic elastase. The N-terminus and disulphide bridges [PDF]
, 1967 JR Brown, D.L. Kauffman, BS Hartley
openalex +1 more source
Epilobiumpyrricholophum Extract Suppresses Porcine Pancreatic Elastase and Cigarette Smoke Extract-Induced Inflammatory response in a Chronic Obstructive Pulmonary Disease Model. [PDF]
Foods, 2021 Jung SY +9 more
europepmc +1 more source
Pathogenic Deep Intronic PCSK1 Variant Causes Proprotein Convertase 1/3 Deficiency in a Family
Clinical Genetics, Volume 108, Issue 1, Page 102-106, July 2025.Biallelic PCSK1 loss‐of‐function mutations cause proprotein convertase 1/3 (PC1/3) deficiency, a polyendocrinopathy; a total of 36 patients were reported. The first deep intronic PCSK1 variant, (NM_000439.5):c.1196+2681T>A, was found to segregate with the disease in a consanguineous family, and is shown together with 32 reported mutations.
Leah M. Huber +6 more
wiley +1 more source
Detection of Peri-Pancreatic Edema using Deep Learning and Radiomics Techniques [PDF]
arXivIdentifying peri-pancreatic edema is a pivotal indicator for identifying disease progression and prognosis, emphasizing the critical need for accurate detection and assessment in pancreatitis diagnosis and management. This study \textit{introduces a novel CT dataset sourced from 255 patients with pancreatic diseases, featuring annotated pancreas ...
arxiv
Deep Supervision for Pancreatic Cyst Segmentation in Abdominal CT Scans [PDF]
arXiv, 2017 Automatic segmentation of an organ and its cystic region is a prerequisite of computer-aided diagnosis. In this paper, we focus on pancreatic cyst segmentation in abdominal CT scan. This task is important and very useful in clinical practice yet challenging due to the low contrast in boundary, the variability in location, shape and the different stages
arxiv
Advanced Science, Volume 12, Issue 21, June 5, 2025.Diagram illustrating the binding methods of NPs and biological barriers. The biological carrier‐mediated nanomedicine hitchhiking strategy (BCM‐NHS) utilizes two distinct techniques: the surface‐based “Backpack” method, which relies on ligand‐receptor binding, covalent conjugation, and non‐covalent binding, and the encapsulated “Trojan horse” approach,
Yuyan Zhou +17 more
wiley +1 more source