Results 21 to 30 of about 253,620 (220)

Neutrophil-mediated injury to endothelial cells. Enhancement by endotoxin and essential role of neutrophil elastase [PDF]

, 1986
The neutrophil has been implicated as an important mediator of vascular injury, especially after endotoxemia. This study examines neutrophil-mediated injury to human microvascular endothelial cells in vitro. We found that neutrophils stimulated by formyl-
M G Tonnesen, Guthrie, L A, P M Henson, G S Worthen, C Haslett, Tonnesen, M G, Smedly, LA, Worthen, G S, Sandhaus, R A, R B Johnston, Henson, P M, L A Guthrie, L A Smedly, Johnstone Jr., R.B, Haslett, Christopher, R A Sandhaus   +15 more
core   +1 more source

Impaired exocrine pancreatic function in different stages of type 1 diabetes

BMJ Open Diabetes Research & Care, 2021
Introduction Aim of this study was to investigate the pancreatic exocrine function in patients with type 1 diabetes (T1D) by multiple non-invasive tests.Research design and methods The study is a single-center, cross-sectional study of pancreatic ...
Giulia Martina Cavestro, Emanuele Bosi, Manuela Battaglia, Nicoletta Dozio, Rita Indirli, Gian Maria Giamporcaro, Laura Frosio, Alessandra Mandelli, Andrea Laurenzi, Andrea Mario Bolla, Angela Stabilini, Andrea Valle, Massimo Locatelli, Marina Scavini   +13 more
doaj   +1 more source

Interleukin-1α Mediates Pancreatic Fibroblast Activation, Regulates Immune Cell Recruitment and Fibrosis in Acute and Chronic Pancreatitis. [PDF]

Adv Sci (Weinh)
During pancreatitis, IL‐1α is released from necrotic acinar cells. In response to IL‐1α, pancreatic fibroblasts release chemokines and cytokines that regulate the recruitment of immune cells to the damaged organ. Furthermore, IL‐1α primes fibroblasts, resulting in increased tissue fibrosis during chronic pancreatitis.
Mazloum H, Buchholz S, Schifter H, Ameling S, Steil L, Becker BL, Hammer E, Homuth G, Völker U, Bröker BM, Zierke L, Weiss FU, Glaubitz J, Sendler M.   +13 more
europepmc   +2 more sources

Paternal mosaicism proves the pathogenic nature of mutations in neutrophil elastase in severe congenital neutropenia [PDF]

, 2002
Heterozygous mutations in neutrophil elastase have been detected in many sporadic cases of congenital neutropenia. However, a convincing pathogenetic mechanism has not been established, and it is unclear whether the effects of the mutant enzyme occur ...
Ancliff, PJ, Gale, RE, David C. Linch, Rosemary E. Gale, Ri Liesner, Phil J. Ancliff, Ian M. Hann, Strobel, S, Liesner, R, Hann, IM, Watts, MJ, Michael J. Watts, Stephan Strobel, Linch, DC   +13 more
core   +1 more source

EXOCRINE PANCREATIC INSUFFICIENCY IN CHILDREN WITH TYPE 1 DIABETES MELLITUS: A NEW PROBLEM OF PEDIATRIC GASTROENTEROLOGY

Вопросы современной педиатрии, 2013
One of the complications of diabetes mellitus is the development of pancreatic exocrine insufficiency. Fecal elastase 1 is a good marker of pancreatic exocrine secretion.
A. A. Nizhevich, G. M. Yakupova, O. A. Malievskii, E. N. Akhmadeeva, A. M. Farkhutdinova   +4 more
doaj   +1 more source

Assessment of bioelectrical impedance analysis in patients with chronic pancreatitis and chronic obstructive pulmonary disease considering exocrine pancreatic insufficiency

Journal of Education, Health and Sport, 2021
The article describes and analyzes the results of bioelectrical impedance analysis in patients with chronic pancreatitis and chronic obstructive pulmonary disease considering the level of fecal elastase-1.The aim of our study was to investigate the ...
T. Lazaruk, O. Fediv
doaj   +1 more source

COMPARISON OF FECAL ELASTASE 1 FOR EXOCRINE PANCREATIC INSUFFICIENCY EVALUATION BETWEEN EX-ALCOHOLICS AND CHRONIC PANCREATITIS PATIENTS

Arquivos de Gastroenterologia, 2014
Context Fecal elastase is a noninvasive test for pancreatic insufficiency diagnosis. Objectives Evaluate the usefulness of fecal elastase 1 for the indication of exocrine pancreatic insufficiency among former alcohol addicts and patients with chronic ...
Rejane MATTAR, Gustavo André Silva LIMA, Marianges Zadrozny Gouvêa da COSTA, Joyce M Kinoshita SILVA-ETTO, Dulce GUARITA, Flair José CARRILHO   +5 more
doaj   +1 more source

Studies on porcine pancreatic elastase activity. I. Radioimmuoassay of porcine pancreatic elastase.

The Tohoku Journal of Experimental Medicine, 1980
An improved method of radioimmunoassay was devised to offer a successful formula for determining blood concentration of elastase. With porcine pancreatic elastase as the antigen, rabbits were immunized to obtain antiserum. Iodinated elastase labeled by the chloramine-T procedure using 131I (or 125I) had a specific activity of 200-300 mCi/mg. The double
NAKAJIMA, YASUYUKI, MATSUNO, SEIKI, NOTO, NOBORU, SAITOR, YOICHI, SATO, TOSHIO   +4 more
openaire   +3 more sources

Fecal elastase-1 and ultrasonography for assessment of exocrine pancreatic function in children with cystic fibrosis [PDF]

Zagazig University Medical Journal
Background: Cystic fibrosis (CF) is an autosomal recessive disorder affecting the exocrine functions of many organs including the pancreas. Clinical and laboratory recognition of pancreatic insufficiency is important for proper treatment.
Khalid Salah, Aya Abd-Allah, Sameh Hegab, Hanan Sameer, Dina Sarhan   +4 more
doaj   +1 more source

Cyclic AMP signalling in pancreatic islets [PDF]

, 2010
Cyclic 3'5'AMP (cAMP) is an important physiological amplifier of glucose-induced insulin secretion by the pancreatic islet β-cell, where it is formed by the activity of adenylyl cyclases, which are stimulated by glucose, through elevation in ...
Nigel J. Pyne, Pyne, Nigel J., Brian Furman, Wee Kiat Ong, Furman, Brian L., Ong, Wee Kiat, Ong, W.K., Furman, Brian   +7 more
core   +4 more sources