Results 11 to 20 of about 253,620 (220)

Evaluation of pancreatic elastase-1 measurement during health checkups for detection of pancreatic cancer in asymptomatic individuals

Cancer Treatment and Research Communications
Objectives: Early detection of pancreatic cancer before symptom onset improves curability. This study evaluated the utility of blood elastase-1 as a screening tool for pancreatic cancer in asymptomatic individuals. Methods: A total of 200,583 individuals
Haruka Itoh, Satomi Asai, Shinji Takashimizu, Toshio Nakagohri, Yasuhiro Nishizaki, Hayato Miyachi   +5 more
doaj   +2 more sources

Exocrine pancreatic insufficiency: prevalence, diagnosis, and management

Clinical and Experimental Gastroenterology, 2019
Gabriele Capurso,1 Mariaemilia Traini,1 Matteo Piciucchi,2 Marianna Signoretti,2 Paolo Giorgio Arcidiacono1 1Pancreato-Biliary Endoscopy and Endosonography Division, Pancreas Translational and Clinical Research Centre, San Raffaele Scientific Institute ...
Capurso G, Traini M, Piciucchi M, Signoretti M, Arcidiacono PG   +4 more
doaj   +1 more source

Fragment Coverage: Unified Visualization and Quantitative Assessment of MS/MS Fragmentation Supports Metabolite Identification in Macromolecule Drug Metabolism Studies. [PDF]

Rapid Commun Mass Spectrom
ABSTRACT Rationale Peptides and oligonucleotides are increasingly used as therapeutic agents, making the identification and structural elucidation of their metabolites a critical step in drug development. Liquid chromatography–mass spectrometry (LC‐MS/MS) is the primary analytical technique for this purpose; however, extensive backbone fragmentation ...
Cifuentes P, Garriga A, Fontaine F, Zamora I.   +3 more
europepmc   +2 more sources

Dorsal Pancreatic Agenesis Associated With New-Onset Diabetes Mellitus and Acute Pancreatitis in an 18-Year-Old Man: A Case Report. [PDF]

Clin Case Rep
ABSTRACT Dorsal pancreatic agenesis (DPA) is a rare congenital disorder resulting from failure of development of the dorsal pancreatic bud. Complete DPA implies absence of the pancreatic neck, body, and tail and can be associated with both diabetes mellitus and pancreatitis. The patient was an 18‐year‐old man admitted with a history of epigastric pain,
Rab M, Javaid MH, Numani RN, Khanam F, Khalid M, Segawa F.   +5 more
europepmc   +2 more sources

Aetiology-Specific Pancreatic Enzyme Dose Requirements and Treatment Outcomes in Pancreatic Exocrine Insufficiency: The Multicentre EURO-PEI Registry. [PDF]

United European Gastroenterol J
ABSTRACT Background Pancreatic exocrine insufficiency (PEI) is a maldigestion syndrome leading to symptoms and nutritional deficiencies. Prospective real‐world data on pancreatic enzyme replacement therapy (PERT) dose requirements across aetiologies are limited. Objective To define PERT dose requirements and treatment outcomes across PEI aetiologies in
Domínguez-Muñoz JE, Domínguez-Novoa Y, Martínez-Seara X, Hegyi P, Rebours V, Phillips ME, Bolado F, Capurso G, de Marchi G, Roberts KJ, Eperjesi O, Salmeron S, Ruiz-Clavijo D, Lauri G, Brillo A, Powell-Brett S, Lariño-Noia J, Iglesias-García J.   +17 more
europepmc   +2 more sources

The level of pancreatic fecal elastase-1 and the risk of cardiovascular complications in patients with chronic pancreatitis combined with arterial hypertension

Gastroenterologìa, 2023
Background. Chronic pancreatitis and malnutrition are associated with cardiovascular diseases and cardiovascular events, while the role of exocrine pancreatic insufficiency as a risk factor for cardiovascular events is unknown.
A.Yu. Filippova, V.V. Kryvoshei
doaj   +1 more source

Pancreatic biomarkers: role in diabetes mellitus

Journal of Pancreatology, 2023
Diabetes mellitus refers to a group of diseases that cause high blood sugar levels. The most common type is type 2 diabetes, which is caused by insulin resistance and inadequate insulin production.
Sana Rafaqat, Ramsha Hafeez, Rida Mairaj, Abeerah Saleem, Saira Rafaqat   +4 more
doaj   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Shear Stress Induces the Release of an Endothelial Elastase: Role in Integrin alpha(v)beta(3)-Mediated FGF-2 Release [PDF]

, 2011
Background/Aims: Laminar shear stress is an important stimulus in the endothelium-dependent control of vascular tone and of vascular remodeling processes.
Hennig, Theres, Christina Mogensen, Gloe, Torsten, Kirsch, Julian, Julian Kirsch, Torsten Gloe, Ulrich Pohl, Pohl, Ulrich, Theres Hennig, Mogensen, Christina   +9 more
core   +1 more source

Parallel Murine and Human Aortic Wall Genomics Reveals Metabolic Reprogramming as Key Driver of Abdominal Aortic Aneurysm Progression

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background While numerous interventions effectively interfered with abdominal aortic aneurysm (AAA) formation/progression in preclinical models, none of the successes translated into clinical success.
Gabor Gäbel, Bernd H. Northoff, Amanda Balboa, Mediha Becirovic‐ Agic, Marcelo Petri, Albert Busch, Lars Maegdefessel, Adrian Mahlmann, Stefan Ludwig, Daniel Teupser, Vivian de Waard, Jonathan Golledge, Anders Wanhainen, Dick Wågsäter, Lesca M. Holdt, Jan H. N. Lindeman   +15 more
doaj   +1 more source