Results 41 to 50 of about 14,181 (179)

Pancreatic function in children with non-alcoholic fatty pancreas disease

Zaporožskij Medicinskij Žurnal, 2019
Objective. To study the features of pancreatic function in children with pancreatic steatosis. Materials and methods. We examined 77 children; the average age of patients was (11.59 ± 2.82) years.
Yu. M. Stepanov, O. Yu. Lukianenko, N. Yu. Zavhorodnia, O. M. Tatarchuk, N. H. Hravirovska, I. A. Klenina   +5 more
doaj   +1 more source

Basophils in Immunity: Activation Pathways, Roles in Allergy and AllergoOncology and Application of the Basophil Activation Test

Allergy, EarlyView.
ABSTRACT Basophils, the least abundant leukocytes, are increasingly recognised as potent immunomodulators. Upon activation, they rapidly release preformed granule‐associated mediators including histamine and lipid mediators such as LTC4, while cytokine production occurs over a longer timescale, contributing to downstream immune responses.
Jitesh Chauhan, Sofia Vlasova, Alicia Chenoweth, Debra H. Josephs, Heather J. Bax, Sophia N. Karagiannis   +5 more
wiley   +1 more source

Evaluation of malnutrition with blood ghrelin and fecal elastase levels in acute decompensated heart failure patients

Türk Kardiyoloji Derneği Arşivi, 2015
Objectives: Exocrine pancreatic dysfunction may contribute to malnutrition and lack of appetite in the advanced stages of heart failure. Nutritional assessment was carried out on patients diagnosed with mild or moderate/severe heart failure.
Mustafa Özcan, Güzin Zeren Öztürk, Murat Köse, Samim Emet, Şengül Aydın, Kadem Arslan, Yücel Arman, Vakur Akkaya, Tufan Tükek   +8 more
doaj   +1 more source

Targeting PCSK9 in Vascular Smooth Muscle Cells: An Effective Strategy to Suppress Ferroptosis and Attenuate Abdominal Aortic Aneurysm Progression

Cell Proliferation, EarlyView.
PCSK9 aggravates AAA by promoting ferroptosis in VSMCs. In the pathological AAA environment, PCSK9 upregulation triggers ferritinophagy‐dependent degradation of FTH1, leading to Fe2+ release, triggering lipid peroxidation and ferroptosis, exacerbating AAA.
Mengdie Xia, Man Li, Yanyu Chen, Jialin Chen, Yuting Cui, Xi‐Long Zheng, Jing Yang, Bingzhao Li, Xiaofeng Ma, Miao Liu, Gang Fan, Juan Peng, Xiaoyan Dai, Zhihan Tang   +13 more
wiley   +1 more source

Features of Pancreatic Pathology in Children

Gastroenterologìa, 2016
Background. The prevalence of pancreatitis in children with digestive disorders is 5–25 %. Aim of research: to determine the prevalence of pancreatic pathology in children. Material and methods.
T.V. Sorokman, O.-M.V. Popelyuk
doaj   +1 more source

Biogenesis of TNF‐α‐insights into proteostasis and inflammation

The FEBS Journal, EarlyView.
TNF‐α biogenesis, trafficking, and signalling are tightly and reciprocally coupled to cellular proteostasis systems, including ER chaperones and endoplasmic reticulum‐associated degradation. This bidirectional crosstalk determines whether TNF‐α responses are adaptive or proteotoxic.
Bailasan Haidar, Céline Philippe, Eric Chevet, Jiří Zahradník   +3 more
wiley   +1 more source

Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction

Obesity Reviews, EarlyView.
Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey, Irene Pomares‐Bri, Paula de Juan‐Maciá, Mariló Olivares‐Vicente, Enrique Barrajón‐Catalán, Vicente Micol, Enrique Roche, María Herranz‐López   +7 more
wiley   +1 more source

Clinical features of different variants of excretory pancreatic insufficiency

Терапевтический архив, 2009
Aim. To analyse course of excretory pancreatic insufficiency (EPI) of pancreatic and not origin as well as factors associated with its development. Material and methods.
Mariya Fedorovna Osipenko, Yu Yu Venzhina, M F Osipenko, Yu Yu Venzhina   +3 more
doaj  

Fatty pancreas disease in newly diagnosed type 2 diabetes patients: a case–control study on relationships with glycemic control and exocrine function

Diabetology & Metabolic Syndrome
Background Fatty pancreas disease (FPD) is characterized by abnormal fat accumulation in pancreatic tissue and is often associated with obesity, metabolic syndrome, and type 2 diabetes mellitus (T2DM).
Tahsin Taner Karaevren, Refika Yorulmaz, Mahinur Cerit, Halit Nahit Şendur, Burak Kalafat, Gizem Yaz Aydın, Özlem Gülbahar, Mehmet Muhittin Yalçın, Ayhan Karakoç, Müjde Aktürk, Füsun Baloş Törüner, Alev Eroğlu Altınova, Taha Enes Çetin, Ethem Turgay Cerit   +13 more
doaj   +1 more source

Fragment Coverage: Unified Visualization and Quantitative Assessment of MS/MS Fragmentation Supports Metabolite Identification in Macromolecule Drug Metabolism Studies

Rapid Communications in Mass Spectrometry, Volume 40, Issue 21, 15 November 2026.
ABSTRACT Rationale Peptides and oligonucleotides are increasingly used as therapeutic agents, making the identification and structural elucidation of their metabolites a critical step in drug development. Liquid chromatography–mass spectrometry (LC‐MS/MS) is the primary analytical technique for this purpose; however, extensive backbone fragmentation ...
Paula Cifuentes, Albert Garriga, Fabien Fontaine, Ismael Zamora   +3 more
wiley   +1 more source