Results 51 to 60 of about 25,336 (285)
Removal of luminal content protects the small intestine during hemorrhagic shock but is not sufficient to prevent lung injury. [PDF]
, 2013 The small intestine plays a key role in the pathogenesis of multiple organ failure following circulatory shock. Current results show that reduced perfusion of the small intestine compromises the mucosal epithelial barrier, and the intestinal contents ...
Altshuler, Angelina E +5 more
core +2 more sources
Assessment of Exocrine Pancreatic Insufficiency in Type 2 Diabetic Mellitus Patients Presenting with Dyspepsia: A Cross-sectional Observational Study [PDF]
Avicenna Journal of Medical BiochemistryBackground: Diabetes mellitus (DM) virtually affects the gastrointestinal (GI) tract in protean ways, including but not limited to small intestinal bacterial overgrowth, GI reflux disease, gastroparesis, neuropathy, pancreatopathy, and non-alcoholic ...
Nidhi Bhutra, Ravi Kant
doaj +1 more source
A Bioinformatics Study for Recognition of Hub Genes and Pathways in Pancreatic Ductal Adenocarcinoma [PDF]
arXiv, 2023 Background: The aim of this study is to use bioinformatics to discover the biomarkers associated with patients with Pancreatic Ductal Adenocarcinoma(PDAC). Material and Methods: GSE28735, GSE15471, and GSE62452 are gene microarray datasets drived from the GEO database, included 153 PDAC samples and 145 normal samples. By analyzing both Gene Ontology (
arxiv
Advanced Science, EarlyView.CXCL6's function in cholangiocarcinoma is underexplored. Here it is discovered that CXCL6 is upregulated in cholangiocarcinoma tissues and promotes proliferation and metastasis of it. CXCL6 functions through the CXCR1/2‐JAK‐STAT/PI3K axis and reshaping tumor lipid metabolism.
Tian He +15 more
wiley +1 more source
Diabetic retinopathy: could the alpha-1 antitrypsin be a therapeutic option? [PDF]
, 2014 Diabetic retinopathy is one of the most important causes of blindness. The underlying mechanisms of this disease include inflammatory changes and remodeling processes of the extracellular-matrix (ECM) leading to pericyte and vascular endothelial cell ...
Chuluyan, Hector Eduardo +3 more
core +1 more source
The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis
Advanced Science, EarlyView.This review summarizes recent advances in understanding the immune microenvironment's role in fibrosis, focusing on phenotypic/functional alterations of immune cells and their dynamic interactions with other cellular constituents within tissues. The authors further explore therapeutic opportunities and challenges in targeting immune microenvironment ...
Xiangqi Chen +6 more
wiley +1 more source
Pancreatic function in children with non-alcoholic fatty pancreas disease
Zaporožskij Medicinskij Žurnal, 2019 Objective. To study the features of pancreatic function in children with pancreatic steatosis. Materials and methods. We examined 77 children; the average age of patients was (11.59 ± 2.82) years.
Yu. M. Stepanov +5 more
doaj +1 more source
Brazilian Journal of Pharmaceutical Sciences, 2021 We investigated the effect of Punica granatum peel aqueous extract (PGE), on pulmonary inflammation and alveolar degradation induced by intratracheal administration of Elastase in Sprague Dawley rats.
Zioud Fatma +7 more
doaj +1 more source
Advanced Science, EarlyView.Trypstatin, a 61‐amino acid Kunitz‐type protease inhibitor derived from human Bikunin, potently inhibits TMPRSS2 and related proteases. It blocks spike‐ and hemagglutinin‐mediated entry of multiple respiratory viruses in vitro reduces SARS‐CoV‐2 replication in human airway cultures, and lowers viral load and symptoms in infected hamsters, demonstrating
Jan Lawrenz +24 more
wiley +1 more source
Türk Kardiyoloji Derneği Arşivi, 2015 Objectives: Exocrine pancreatic dysfunction may contribute to malnutrition and lack of appetite in the advanced stages of heart failure. Nutritional assessment was carried out on patients diagnosed with mild or moderate/severe heart failure.
Mustafa Özcan +8 more
doaj +1 more source