Integrating Dialysis in Ex Situ Machine Perfusion: A Systematic Review and Meta‐Analysis of Outcomes
Artificial Organs, EarlyView.Dialysis‐enhanced EVMP effectively maintains biochemical homeostasis, potentially mitigating metabolic stress and extending perfusion duration. Functional outcomes varied depending on the organ type, with the most pronounced benefits observed in cardiac perfusion.
Yomna E. Dean +12 more
wiley +1 more source
Possible heterogeneity of initial pancreatic islet beta‐cell autoimmunity heralding type 1 diabetes [PDF]
, 2023 Åke Lernmark +9 more
openalex +1 more source
Treatment options for immune‐related adverse events associated with immune checkpoint inhibitors
British Journal of Pharmacology, EarlyView.Abstract The immunotherapy revolution with the use of immune checkpoint inhibitors (ICIs) started with the clinical use of the first ICI, ipilimumab, in 2011. Since then, the field of ICI therapy has rapidly expanded — with the FDA approval of 10 different ICI drugs so far and their incorporation into the therapeutic regimens of a range of malignancies.
Yu Hua Chen +3 more
wiley +1 more source
Diphenylhydantoin Suppresses Glucose-Induced Insulin Release by Decreasing Cytoplasmic H+ Concentration in Pancreatic Islets [PDF]
, 2006 Koichiro Nabe +9 more
openalex +1 more source
Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?
British Journal of Pharmacology, EarlyView.Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli +7 more
wiley +1 more source
Cell Transplantation, 2006 Development of an efficient preculture system of islets is ideal. Toward that goal, we constructed a human pancreatic islet-derived fibroblast cell line MNNK-1 for a source as a coculture system for freshly isolated islets to maintain islet functions ...
Atsushi Miki +15 more
doaj +1 more source
Stillbirth in pregnancies with flat OGTT: Placental clues to occult maternal dysmetabolism
International Journal of Gynecology &Obstetrics, EarlyView.
Emma Bertucci +10 more
wiley +1 more source
The return of metabolism: biochemistry and physiology of glycolysis
Biological Reviews, EarlyView.ABSTRACT Glycolysis is a fundamental metabolic pathway central to the bioenergetics and physiology of virtually all living organisms. In this comprehensive review, we explore the intricate biochemical principles and evolutionary origins of glycolytic pathways, from the classical Embden–Meyerhof–Parnas (EMP) pathway in humans to various prokaryotic and ...
Nana‐Maria Grüning +19 more
wiley +1 more source
Revisiting pancreatic islet isolation in murine models: A practical and effective technical protocol
Physiological ReportsThe endocrine pancreas is composed of clusters of cell groups called pancreatic islets. These cells are responsible for the synthesis and secretion of hormones crucial for glycemic homeostasis, such as insulin and glucagon.
Aline Fernandes‐da‐Silva +3 more
doaj +1 more source
Regulation of Insulin Secretion Through Long‐Chain Fatty Acid Receptors
iNew Medicine, EarlyView.
Stefan Offermanns
wiley +1 more source