Results 61 to 70 of about 39,716 (234)

Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies

Advanced Science, EarlyView.
In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang, Xinxin Zou, Jiansong Zhou, Qinmiao Sun, Dahua Chen   +4 more
wiley   +1 more source

CCT2 Promotes Prostate Cancer Progression Through EIF3F‐Dependent Stabilization of FASN

Advanced Science, EarlyView.
ABSTRACT Prostate cancer (PCa) is increasingly recognized to be driven by dysregulated lipid metabolism. Although fatty acid synthase (FASN) is highly expressed in PCa, the mechanisms governing FASN protein stability and its functional integration into oncogenic lipid metabolism remain poorly defined.
Shun Xu, Yifan Zhang, Haolin Li, Shengyu Zhao, Xiaoran Dai, Qili Xu, Mintian Fei, Chun Li, Zhihui Zou, Baojun Wang, Li Zhang, Hui Wang, Ligang Zhang, Chaozhao Liang   +13 more
wiley   +1 more source

Real-World Effectiveness of Capecitabine and Temozolomide Across Endocrine and Neuroendocrine Neoplasm Subtypes (ENENs): A Population-Based Cohort Study from Alberta, Canada (2011–2021)

Current Oncology
Capecitabine plus temozolomide (CAPTEM) improves progression-free survival (PFS) in pancreatic endocrine and neuroendocrine neoplasms (PNENs), yet its real-world effectiveness across other endocrine and neuroendocrine neoplasm (ENEN) subtypes remains ...
Alda Aleksi, Kaiden D. Jobin, Malek B. Hannouf, Patrik Husi, Heather Halperin, Chris White-Gloria, Tasnima Abedin, Dean Ruether   +7 more
doaj   +1 more source

A rare presentation of an ACTH‐producing high‐grade large cell neuroendocrine carcinoma with Cushing’s syndrome

Clinical Case Reports, 2021
High‐grade neuroendocrine tumors (HGNET) are rare neoplasms composed of neural and hormonal with only around 42 cases reported in the last 20 years1.
Francis Essien, Christine Persaud, David Dado, Rina Eden, Joshua Tate, George Shahin   +5 more
doaj   +1 more source

Advances in Cancer Immunotherapy for Solid Tumors

Advanced Science, EarlyView.
Cancer immunotherapy for solid tumors is rapidly evolving beyond classical checkpoint blockade toward more precise strategies. Emerging checkpoint targets, bispecific antibodies, antibody–drug conjugate combinations, personalized vaccines, cellular therapies, and engineered cytokines are expanding therapeutic possibilities, while biomarker‐guided ...
Shira Gabizon‐Peretz, Harriet M. Kluger   +1 more
wiley   +1 more source

Rare breast and subcutaneous metastases from pancreatic neuroendocrine tumor: a case report

World Journal of Surgical Oncology, 2019
Background Neuroendocrine tumors are a group of rare neoplasms, and the pancreatic neuroendocrine tumors (PNETs) represent only 1–2% of all pancreatic malignant tumors.
Dorotea Bosco, Salvatore Perrotti, Corrado Spatola, Giada Maria Vecchio, Rosalia Latino, Antonio Di Cataldo   +5 more
doaj   +1 more source

Endoscopic Ultrasound-Guided Ablation of Focal Pancreatic Lesions: The GRUPUGE Perspective

GE: Portuguese Journal of Gastroenterology, 2020
Focal pancreatic lesions include a heterogeneous group of solid and cystic lesions, with different natures and variable clinical, imagiological, and pathological characteristics.
Miguel Bispo, Ana Caldeira, Sílvia Leite, Susana Marques, Teresa Moreira, Pedro Moutinho-Ribeiro, Nuno Nunes   +6 more
doaj   +1 more source

Current update on imaging for pancreatic neuroendocrine neoplasms

World Journal of Clinical Oncology, 2021
Pancreatic neuroendocrine neoplasms (panNEN) are a heterogeneous group of tumors with differing pathological, genetic, and clinical features. Based on clinical findings, they may be categorized into functioning and nonfunctioning tumors. Adoption of the 2017 World Health Organization classification system, particularly its differentiation between grade
Segaran, Nicole, Devine, Catherine, Wang, Mindy, Ganeshan, Dhakshinamoorthy   +3 more
openaire   +2 more sources

Rising Pancreatic Cancer Incidence in Young Japanese Women and Increasing Distal Pancreatectomy in Older Adults: A Nationwide Claims‐Based Analysis From 2016 to 2023

Annals of Gastroenterological Surgery, EarlyView.
This nationwide claims‐based study analyzed recent trends in pancreatic cancer incidence (2016–2021) and surgery (2016–2023) in Japan. The study revealed a rising incidence of pancreatic cancer, notably among young women, and an increasing use of distal pancreatectomy among older adults.
Masamitsu Kido, Ryo Morimura, Yusuke Yamamoto, Tomohiro Arita, Shingo Nakashima, Katsutoshi Shoda, Taisuke Imamura, Hidemasa Kubo, Kengo Yoshii, Iichiroh Onishi, Atsushi Shiozaki   +10 more
wiley   +1 more source

Exosomal miRNA signatures of pancreatic lesions

BMC Gastroenterology, 2020
Background Pancreatic and peri-pancreatic neoplasms encompass a variety of histotypes characterized by a heterogeneous prognostic impact. miRNAs are considered efficient candidate biomarkers due to their high stability in tissues and body fluids.
Caterina Vicentini, Federica Calore, Giovanni Nigita, Paolo Fadda, Michele Simbolo, Nicola Sperandio, Claudio Luchini, Rita T. Lawlor, Carlo Maria Croce, Vincenzo Corbo, Matteo Fassan, Aldo Scarpa   +11 more
doaj   +1 more source