Results 51 to 60 of about 1,457,192 (230)

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

Angewandte Chemie, EarlyView.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma, Komal Sharma, Anku Sharma, Kamya Rao, Rahul Jain, Brett VanVeller   +5 more
wiley   +2 more sources

EFEMP1 binds the EGF receptor and activates MAPK and Akt pathways in pancreatic carcinoma cells [PDF]

, 2009
The EGF-related protein EFEMP1 (EGF-containing fibulin-like extracellular matrix protein 1) has been shown to promote tumor growth in human adenocarcinoma.
Jauch, Karl-Walter, Krebs, Stefan, Blum, Helmut, Bruns, Christiane J., De Toni, Enrico N., Ischenko, Ivan, Camaj, Peter, Seeliger, Hendrik, Faktorova, Dagmar   +8 more
core   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Transformation of Nonfunctioning Pancreatic Neuroendocrine Carcinoma Cells into Insulin Producing Cells after Treatment with Sunitinib [PDF]

Endocrinology and Metabolism, 2013
We report a rare case of severe hypoglycemia after sunitinib treatment for pancreatic neuroendocrine carcinoma. We describe the initial clinical presentation, laboratory results, pathologic findings, and managment in a patient with a nonfunctioning ...
Jung Hun Ohn, Yeong Gi Kim, Se-Hoon Lee, Hye Seung Jung   +3 more
doaj   +1 more source

Case Report: A Difficult-to-Diagnose Case of Hyperinsulinemic Hypoglycemia Surgically Treated After Developing Acute Pancreatitis

Frontiers in Endocrinology, 2021
The patient is a 28-year-old Japanese man diagnosed with severe congenital hyperinsulinemic-hypoglycemia six months after birth. Clinical records revealed no imaging evidence of pancreatic tumor at the time of diagnosis.
Chisa Inoue, Kota Nishihama, Aoi Hayasaki, Yuko Okano, Akinobu Hayashi, Kazuhito Eguchi, Mei Uemura, Toshinari Suzuki, Taro Yasuma, Takeshi Inoue, Tohru Yorifuji, Shugo Mizuno, Esteban C. Gabazza, Yutaka Yano   +13 more
doaj   +1 more source

The North American Neuroendocrine Tumor Society Consensus Paper on the Surgical Management of Pancreatic Neuroendocrine Tumors [PDF]

, 2020
This manuscript is the result of the North American Neuroendocrine Tumor Society consensus conference on the surgical management of pancreatic neuroendocrine tumors from July 19 to 20, 2018.
Halfdanarson, Thorvardur R, Michelle K. Kim, Tseng, Jennifer F, Chan, Jennifer A, Merchant, Nipun B, Hope, Thomas A, Minter, Rebecca M, Lee, Jeffrey E, Terry C. Lairmore, Menda, Yusuf, Claudius Conrad, Drebin, Jeffrey A, Howe, James R, Rodney F. Pommier, Jennifer F. Tseng, Hallet, Julie, Jeffrey E. Lee, Libutti, Steven K, Lairmore, Terry C, Kim, Michelle K, Rebecca M. Minter, Yusuf Menda, Jeffrey A. Drebin, Jennifer A. Chan, Xavier M. Keutgen, Thomas A. Hope, James R. Howe, Steven K. Libutti, Nipun B. Merchant, Keutgen, Xavier M, Gagandeep Singh, Pommier, Rodney F, Thorvardur R. Halfdanarson, Conrad, Claudius, Julie Hallet, Herbert J. Zeh, Zeh, Herbert J, Singh, Gagandeep   +37 more
core   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Outcomes Following Observation of Small Non-Functioning Neuroendocrine Tumors of the Pancreas. Data from the Registry of the Loginov Moscow Clinical Scientific Center

Российский журнал гастроэнтерологии, гепатологии, колопроктологии
Aim: to evaluate results of follow-up of patients with pancreatic non-functioning neuroendocrine tumors of the stage T1–T2 using a medical registry.Materials and methods.
I. E. Khatkov, D. A. Salimgereeva, I. Yu. Feidorov, A. A. Konyakhina, A. L. Petrova   +4 more
doaj   +1 more source

Diabetes mellitus associated with pancreatic somatostatin tumor: A case report

Journal of Clinical and Translational Endocrinology Case Reports, 2016
The finding of diabetes in association with a pancreatic neuroendocrine tumor (PNET) in patients is uncommon. Here, we describe a 74-year-old diabetes patient with a tumor in the pancreatic head.
Bing Han, MD, Hualin Zhai, MD, Jiao Yu, MD, Fangzhen Xia, MD, Yingli Lu, MD   +4 more
doaj   +1 more source