Results 221 to 230 of about 18,206 (254)
Some of the next articles are maybe not open access.
Dangerous liaisons: Pancreatic stellate cells and pancreatic cancer cells
Journal of Gastroenterology and Hepatology (Australia), 2012AbstractOne of the characteristic features of the majority of pancreatic ductal adenocarcinomas is an abundant desmoplastic/stromal reaction. Until recently, this stroma had received little attention from researchers studying the pathogenesis of pancreatic cancer, with most of the research focus resting on the biology of tumor cells themselves. However,
Minoti V Apte, Jeremy S Wilson
exaly +3 more sources
Stellate Cell Activation in Alcoholic Pancreatitis
Pancreas, 2003The pathogenesis of pancreatic fibrosis, a characteristic feature of alcohol-induced chronic pancreatitis, has received increasing attention over the past few years, largely due to the identification and characterization of stellate cells in the pancreas. These cells are morphologically similar to hepatic stellate cells, the principal effector cells in
M V, Apte, J S, Wilson
openaire +2 more sources
Hepatic and pancreatic stellate cells in focus
bchm, 2009Abstract Stellate cells are vitamin A-storing cells of liver and pancreas and have been described in all vertebrates ranging from lampreys (primitive fish) to humans, demonstrating their major importance. This cell type is thought to contribute to fibrosis, a condition characterized by an excess deposition of extracellular matrix ...
Claus, Kordes +2 more
openaire +2 more sources
2015
Of all the different cell types in the pancreatic parenchyma, the most recently discovered cell is the pancreatic stellate cell (PSC). PSCs were first described more than 30 years ago, in 1982. Sixteen years later, in 1998, methods were developed to isolate and culture PSCs from the pancreas, which provided a much-needed impetus to studies on PSC ...
Minoti V. Apte +2 more
openaire +1 more source
Of all the different cell types in the pancreatic parenchyma, the most recently discovered cell is the pancreatic stellate cell (PSC). PSCs were first described more than 30 years ago, in 1982. Sixteen years later, in 1998, methods were developed to isolate and culture PSCs from the pancreas, which provided a much-needed impetus to studies on PSC ...
Minoti V. Apte +2 more
openaire +1 more source
The role of pancreatic stellate cells in pancreatic cancer
Pancreatology, 2013Since conventional and targeted therapies aiming at cancer cells have largely failed to prolong survival in pancreatic cancer, targeting the infrastructure of the tumor, hence its stroma is a novel strategy. It is believed that fibrotic and hypovascular stroma forms a barrier around cancer cells, hindering effective delivery of chemotherapy ...
openaire +2 more sources
Roles of Pancreatic Stellate Cells in Pancreatic Inflammation and Fibrosis
Clinical Gastroenterology and Hepatology, 2009Over a decade, there is accumulating evidence that activated pancreatic stellate cells (PSCs) play a pivotal role in the development of pancreatic fibrosis. In response to pancreatic injury or inflammation, quiescent PSCs are transformed (activated) to myofibroblast-like cells, which express alpha-smooth muscle actin.
Atsushi, Masamune +3 more
openaire +2 more sources
PRESSURE ACTIVATES RAT PANCREATIC STELLATE CELLS.
Pancreas, 2004Pancreatic stellate cells (PSCs) play a central role in development of pancreatic fibrosis. In chronic pancreatitis, pancreatic tissue pressure is higher than that of the normal pancreas. We here evaluate the effects of pressure on the activation of rat PSCs.
Shiro, Watanabe +8 more
openaire +2 more sources
YAP activates pancreatic stellate cells and enhances pancreatic fibrosis
Hepatobiliary & Pancreatic Diseases International, 2022Pancreatic stellate cells (PSCs) foster the progression of pancreatic adenocarcinoma and chronic pancreatitis (CP) by producing a dense fibrotic stroma. However, the incomplete knowledge of PSCs biology hampers the exploration of antifibrotic therapies.
Lennard, Spanehl +4 more
openaire +2 more sources
Pancreatic stellate cells – Multi-functional cells in the pancreas
Pancreatology, 2013There is accumulating evidence that activated pancreatic stellate cells (PSCs) play a pivotal role in pancreatic fibrosis in chronic pancreatitis and pancreatic cancer. In addition, we have seen great progress in our understanding of the cell biology of PSCs and the interactions between PSCs and other cell types in the pancreas.
Atsushi, Masamune, Tooru, Shimosegawa
openaire +2 more sources
Connexins Regulate Cell Functions in Pancreatic Stellate Cells
Pancreas, 2013Pancreatic stellate cells (PSCs) play a pivotal role in pancreatic fibrosis associated with chronic pancreatitis and pancreatic cancer. Connexins (Cxs) allow direct intercellular communications as components of gap junction but also play important roles in the regulation of cell proliferation, cell differentiation, and tissue development.
Atsushi, Masamune +12 more
openaire +2 more sources