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A journey to and with the stars: The pancreatic stellate cell story
Pancreatology, 2023The George E Palade Prize is the highest honour awarded by the International Association of Pancreatology, that recognises an individual who has made outstanding contributions to the understanding of the pancreas and pancreatic diseases. The 2023 Palade Prize was awarded to Professor Minoti Apte, University of New South Wales Sydney on September 16 ...
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Characterization of Tumor-Derived Pancreatic Stellate Cells
Journal of Surgical Research, 2009Pancreatic stellate cells (PSCs) are key mediators of the desmoplastic reaction that characterizes pancreatic adenocarcinoma. We sought to isolate and characterize tumor-derived pancreatic stellate (TDPS) cells to further understand how these stromal cells influence pancreatic cancer behavior.We established a stable line of non-immortalized PSCs from a
Buckminster, Farrow +3 more
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Curcumin blocks activation of pancreatic stellate cells
Journal of Cellular Biochemistry, 2005AbstractActivated pancreatic stellate cells (PSCs) play a pivotal role in the pathogenesis of pancreatic fibrosis and inflammation. Inhibition of activation and cell functions of PSCs is a potential target for the treatment of pancreatic fibrosis and inflammation.
Atsushi, Masamune +5 more
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Pancreatic stellate cells—role in pancreas cancer
Langenbeck's Archives of Surgery, 2008Adenocarcinomas of the pancreas are characterized by a rapid progression, an early metastasis, a limited response to chemo- and radiotherapy, and an intense fibrotic reaction known as tumor desmoplasia. Carcinoma cells are surrounded by a dense stroma consisting of myofibroblast-like cells, collagens, and fibronectin.This review describes the ...
Max G, Bachem +4 more
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Primary Cultures for Pancreatic Stellate Cells (PSCs)
2018Primary cultures of pancreatic stellate cells (PSCs) remain an important basis for in vitro study. However, effective methods for isolating abundant PSCs are currently lacking. This purpose of this chapter is to report our novel approach to isolating PSCs from normal rat pancreas and human pancreatic ductal adenocarcinoma (PDAC) tissue.
Lei, Tian, Zipeng, Lu, Yi, Miao
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Immunocytes and Activated Stellate Cells in Pancreatic Fibrogenesis
Pancreas, 2003Chronic pancreatitis is a progressive chronic inflammatory disease characterized by irreversible destruction of exocrine pancreatic tissue and extensive fibrosis. Excessive alcohol consumption has been identified as the main etiologic factor of this disease in the Western world. Idiopathic pancreatitis accounts for approximately 30% of cases.
Kaz, Jaskiewicz +3 more
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Pancreatic stellate cells promotes the perineural invasion in pancreatic cancer
Medical Hypotheses, 2012Perineural invasion is a prominent characteristic of pancreatic cancer. Pancreatic cancer has an extremely high incidence of perineural invasion which has been associated with poor survival. Early studies mostly focus on the interaction between cancer cells and nerves.
Yu, Zhou, Quanbo, Zhou, Rufu, Chen
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Pancreatic stellate cells and chronic alcoholic pancreatitis
Zeitschrift für Gastroenterologie, 2001N, Teich, V, Keim
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Pancreatic stellate cells: The new stars of chronic pancreatitis?
Gastroenterology, 1998R G, Wells, J M, Crawford
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