Results 111 to 120 of about 552,612 (348)

PLEK2 promotes gallbladder cancer invasion and metastasis through EGFR/CCL2 pathway

Journal of Experimental & Clinical Cancer Research, 2019
Background Gallbladder cancer (GBC) is an extremely malignant tumor with a high mortality rate. Little is known about its invasion and metastasis mechanism so far.
Hui Shen, Min He, Ruirong Lin, Ming Zhan, Sunwang Xu, Xince Huang, Chu Xu, Wei Chen, Yanhua Yao, Man Mohan, Jian Wang   +10 more
doaj   +1 more source

RNA‐Micelles as Self‐Assembling Structures for Efficient Co‐Delivery of Synergistic siRNA and Nucleoside Analogues to Treat CRC Lung Metastasis

Advanced Functional Materials, EarlyView.
Two kinds of self‐assembled RNA micelles were used to co‐deliver synergistic siRNA and nucleoside analogues for the treatment of colorectal cancer lung metastases. Near‐complete elimination of lung cancer metastases was confirmed in an orthotopic lung metastasis model constructed using human colorectal cancer lung metastases patient surgical samples to
Kai Jin, Piotr Rychahou, Daniel W. Binzel, B. Mark Evers, Peixuan Guo   +4 more
wiley   +1 more source

Metabolic dysfunction-associated steatotic liver disease accelerates pancreatic cancer progression and metastasis via the macrophage migration inhibitory factor-CD44 axis

Signal Transduction and Targeted Therapy
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with a poor prognosis, particularly in the presence of liver metastases. The mechanisms by which metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as
Qian Yu, Hui Song, Xiao-ya Shi, Liang Zhu, Yu Liang, Rui-ning Gong, Xiao-wu Dong, Shang-long Liu, Hai-zhen Wang, Ying-luo Wang, Jiu-fa Cui, Xiao-nan Yang, Ying Chen, Chao Gao, Zhan Yang, Qing-tian Zhu, Chang Li, Huan Zhang, Jie-er Ying, Mei-fang Zheng, Yan-tao Tian, Hai-tao Hu, Xin-xin Shao, Yue Li, Ming-guang Mo, Yun Lu, Zheng Ma, Shun-li Fu, Qing-hui Niu, Yuan-yu Liao, Chen-yang Zhao, Xin Liu, Ashok K. Saluja, Ji-gang Wang, Xiao-yu Li, Song-yue Guo, Wei-hua Wang, Song Wang, Bin Liu, Guo-tao Lu, He Ren   +40 more
doaj   +1 more source

Membrane Fusion‐Inspired Nanomaterials: Emerging Strategies for Infectious Disease and Cancer Diagnostics

Advanced Healthcare Materials, EarlyView.
Membrane fusion‐inspired nanomaterials offer transformative potential in diagnostics by mimicking natural fusion processes to achieve highly sensitive and specific detection of disease biomarkers. This review highlights recent advancements in nanomaterial functionalization strategies, signal amplification systems, and stimuli‐responsive fusion designs,
Sojeong Lee, Khulan Nyamzaya, Jueun Han, Yejin Song, Jihee Lee, Jung Hyun Jo, Seungmin Bang, Eun‐Kyung Lim, Seungjoo Haam, Eunjung Kim   +9 more
wiley   +1 more source

Bioprinting Organs—Science or Fiction?—A Review From Students to Students

Advanced Healthcare Materials, EarlyView.
Bioprinting artificial organs has the potential to revolutionize the medical field. This is a comprehensive review of the bioprinting workflow delving into the latest advancements in bioinks, materials and bioprinting techniques, exploring the critical stages of tissue maturation and functionality.
Nicoletta Murenu, Camilla Mussoni, Mateo S. Andrade Mier, Paula Buettner, Nathaly Chicaiza‐Cabezas, Yi‐Yu Robin Dai, Jessica Faber, Maren Fiedler, Zan Lamberger, Xuen Jen Ng, Vanessa Moessler, Anna Rederer, Jonas Roeder, Sabrina Stecher, Katinka Theis, Jeanette Weigelt, Silvia Budday, Gregor Lang, Natascha Schaefer   +18 more
wiley   +1 more source

From Mind to Liver: Exploring the Causal Relationship Between Anxiety Disorders and Non-Alcoholic Fatty Liver Disease Through Mendelian Randomization and UK Biobank Validation

Journal of Multidisciplinary Healthcare
Hui Song,1,* Xiaowu Dong,2,* Qinghui Niu,3 Qian Yu,1 Xiangjia Zhu,4 Hong Zhao,5 Chang Li,6 Guotao Lu,2 Xin Liu7 1Tumor Immunology and Cytotherapy of Medical Research Center, Shandong Provincial Key Laboratory of Clinical Research for ...
Song H, Dong X, Niu Q, Yu Q, Zhu X, Zhao H, Li C, Lu G, Liu X   +8 more
doaj  

Identification of immunogenic cell death signature genes in hepatocellular carcinoma: from single-cell transcriptomics to in vitro mechanistic validation and comprehensive prognostic modeling with hundreds of machine learning algorithms

Frontiers in Immunology
BackgroundHepatocellular carcinoma (HCC) lacks reliable prognostic biomarkers for immunotherapy. Immunogenic cell death (ICD) represents a promising therapeutic target, but its comprehensive characterization in HCC remains unexplored.MethodsWe performed ...
Hongliang Liu, Hongliang Liu, Zhenni Sun, Xi Wang, Bin Zhou, Bin Zhou, Lichao Cha, Lichao Cha   +7 more
doaj   +1 more source

Bioengineered Pancreatic Cancer Immunosuppressive Microenvironment Models for Screening Immunotherapies

Advanced Healthcare Materials, EarlyView.
Bioengineering tumor‐stroma pancreatic cancer models with potential to emulate the native immunosuppressive tumor microenvironment. Cancer‐on‐a‐bead models exhibited higher relevance for screening immunotherapies and modulating the protumoral PDAC microenvironment. ABSTRACT Pancreatic cancer is notably resistant to treatment, primarily due to its dense
Maria V. Monteiro, Margarida Henriques‐Pereira, Bruno M. Neves, Vítor M. Gaspar, João F. Mano   +4 more
wiley   +1 more source

Comparative analysis of deep learning and radiomics models in predicting hepatocellular carcinoma differentiation via ultrasound

Frontiers in Medicine
ObjectiveThis study aimed to develop and compare predictive models for hepatocellular carcinoma (HCC) differentiation using ultrasound-based radiomics and deep learning, and to evaluate the clinical utility of a combined model.MethodsRadiomics and deep ...
Luohang Xu, Yanhua Huang, Hong Fu, Hong Fu, Jianhua Yu, Jianhua Yu, Baochun Lu, Baochun Lu, Yalan Zheng, Jiaxuan Qian, Hongwei Qian, Hongwei Qian   +11 more
doaj   +1 more source

Enhancing Magnetic Hyperthermia at the Cell Membrane by Anchoring 92R‐Functionalized Magnetic Nanoparticles to Low‐Endocytic CCR9 Surface Receptors

Advanced Healthcare Materials, EarlyView.
We present a strategy to enhance magnetic hyperthermia therapy by modulating nanoparticle–cell interactions. Antibody‐functionalized magnetic nanoparticles targeting the low‐internalizing CCR9 receptor enable spatially controlled membrane anchoring, reducing aggregation and maximizing heat generation under alternating magnetic fields.
David Egea‐Benavente, Isabel Corraliza‐Gorjón, Thomas S. van Zanten, María del Puerto Morales, Leonor Kremer, Domingo F. Barber   +5 more
wiley   +1 more source