Results 131 to 140 of about 451,958 (353)

Tryptophan‐sensing receptor GPR142 expression levels are directly regulated by proinflammatory cytokines in ghrelin‐producing cells

FEBS Open Bio, EarlyView.
GPR142, a tryptophan‐sensing receptor, stimulates gastrointestinal hormones like ghrelin and is linked to inflammation regulation. Proinflammatory cytokines suppress ghrelin production, while tryptophan levels decrease via IDO1 activation. Our findings reveal that proinflammatory cytokines directly regulate GPR142 expression in ghrelin‐producing cells,
Yoko Ueda, Hiroshi Iwakura, Takuya Ensho, Mika Bando‐Shimizu, Asako Doi, Norihiko Matsutani, Shuhei Morita, Hidefumi Inaba, Hiroyuki Ariyasu, Naoki Fukuda, Keiji Hayata, Toshiyasu Ojima, Masahiro Nishi, Taka‐aki Matsuoka, Hiroki Yamaue, Takashi Akamizu   +15 more
wiley   +1 more source

A combined radiomics and clinical model for preoperative differentiation of intrahepatic cholangiocarcinoma and intrahepatic bile duct stones with cholangitis: a machine learning approach

Frontiers in Oncology
BackgroundThis study aimed to develop and validate a predictive model integrating radiomics features and clinical variables to differentiate intrahepatic bile duct stones with cholangitis (IBDS-IL) from intrahepatic cholangiocarcinoma (ICC ...
Hongwei Qian, Hongwei Qian, Yanhua Huang, Yuxing Dong, Luohang Xu, Ruanchang Chen, Fangzheng Zhou, Difan Zhou, Difan Zhou, Jianhua Yu, Jianhua Yu, Baochun Lu, Baochun Lu   +12 more
doaj   +1 more source

Determination of Rottlerin, a Natural Protein Kinases C Inhibitor, in Pancreatic Cancer Cells and Mouse Xenografts by RP-HPLC Method. [PDF]

, 2013
Rottlerin is a natural polyphenolic ketone isolated from the pericarps of Mallotus phillippinensis. In previous studies we showed that parenteral administration of rottlerin reduced tumor growth in murine xenograft models of pancreatic cancer. The aim of
Edderkaoui, Mouad, Eibl, Guido, Go, Vay-Liang, Lu, Qing-Yi, Lugea, Aurelia, Moro, Aune, Pandol, Stephen, Zhang, Lifeng   +7 more
core   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Pancreatic Tumor Segmentation as Anomaly Detection in CT Images Using Denoising Diffusion Models [PDF]

arXiv
Despite the advances in medicine, cancer has remained a formidable challenge. Particularly in the case of pancreatic tumors, characterized by their diversity and late diagnosis, early detection poses a significant challenge crucial for effective treatment.
arxiv  

Adenosine A3 receptor antagonists as anti‐tumor treatment in human prostate cancer: an in vitro study

FEBS Open Bio, EarlyView.
The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.
Maria Beatrice Morelli, Andrea Spinaci, Cui Chang, Rosaria Volpini, Catia Lambertucci, Matteo Landriscina, Vincenza Conteduca, Consuelo Amantini, Cristina Aguzzi, Laura Zeppa, Martina Giangrossi, Laura Soverchia, Matteo Santoni, Massimo Nabissi, Giorgio Santoni, Carlo Polidori   +15 more
wiley   +1 more source

Cross-Organ Domain Adaptive Neural Network for Pancreatic Endoscopic Ultrasound Image Segmentation [PDF]

arXiv
Accurate segmentation of lesions in pancreatic endoscopic ultrasound (EUS) images is crucial for effective diagnosis and treatment. However, the collection of enough crisp EUS images for effective diagnosis is arduous. Recently, domain adaptation (DA) has been employed to address these challenges by leveraging related knowledge from other domains. Most
arxiv  

The human pancreatic islet cells and their tumors.II. Ulcerogenic and diarrheogenic tumors [PDF]

, 1974
Marie H. Greider, Juan Rosaí, James E. McGuigan   +2 more
openalex   +1 more source

Possible role of human ribonuclease dicer in the regulation of R loops

FEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik, Paulina Krzeminska, Anna Kurzynska‐Kokorniak   +2 more
wiley   +1 more source

A continuous approach of modeling tumorigenesis and axons regulation for the pancreatic cancer [PDF]

arXiv
The pancreatic innervation undergoes dynamic remodeling during the development of pancreatic ductal adenocarcinoma (PDAC). Denervation experiments have shown that different types of axons can exert either pro- or anti-tumor effects, but conflicting results exist in the literature, leaving the overall influence of the nervous system on PDAC incompletely
arxiv