Results 81 to 90 of about 552,612 (348)

A pilot study evaluating concordance between blood-based and patient-matched tumor molecular testing within pancreatic cancer patients participating in the Know Your Tumor (KYT) initiative [PDF]

, 2016
Recent improvements in next-generation sequencing (NGS) technology have enabled detection of biomarkers in cell-free DNA in blood and may ultimately replace invasive tissue biopsies.
Aberra, Metasebia, Bender, R. Joseph, Brody, Jonathan, Chung, Vincent, Heartwell, Craig, Hendifar, Andrew, Hoos, William A., Madhavan, Subha, Mason, Kimberly, Matrisian, Lynn M., Mikhail, Sam, Petricoin, Emanuel, III, Picozzi, Vincent, Pishvaian, Michael J., Rahib, Lola, Varieur, Katelyn   +15 more
core   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Theoretical investigation of transgastric and intraductal approaches for ultrasound-based thermal therapy of the pancreas. [PDF]

, 2017
BackgroundThe goal of this study was to theoretically investigate the feasibility of intraductal and transgastric approaches to ultrasound-based thermal therapy of pancreatic tumors, and to evaluate possible treatment strategies.MethodsThis study ...
Adams, Matthew S, Diederich, Chris J, Salgaonkar, Vasant, Scott, Serena J, Sommer, F Graham   +4 more
core   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Challenges and hope: latest research trends in the clinical treatment and prognosis of liposarcoma

Frontiers in Pharmacology
Liposarcoma, as a complex disease, is characterized by intricate interactions between distinct histopathological subtypes and corresponding clinical outcomes, emphasizing the necessity of personalized approaches in diagnosis and treatment strategies ...
Hongliang Liu, Xi Wang, Xiaoyu Wang, Fabo Qiu, Bin Zhou   +4 more
doaj   +1 more source

Subharmonic and Endoscopic Contrast Imaging of Pancreatic Masses: A Pilot Study. [PDF]

, 2017
OBJECTIVES: To use subharmonic imaging (SHI) to depict the vascularity of pancreatic masses compared to contrast-enhanced endoscopic ultrasound (EUS) and pathologic results.
Eisenbrey, John R., Forsberg, Flemming, Fox, Traci, Kowalski, Thomas E., Liu, Ji-Bin, Loren, David E., Lyshchik, Andrej, Miller, Cynthia, O\u27Kane, Patrick, Siddiqui, Ali, Stanczak, Maria   +10 more
core   +2 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Da Vinci robot-assisted retroperitoneal tumor resection in 105 patients: a single-center experience

Frontiers in Oncology
BackgroundThe Da Vinci Surgical System (DVSS) has the advantages of minimal invasion, rapid recovery, safety, and reliability. Although the DVSS has been widely used in various abdominal surgeries, descriptions of its use in robot-assisted ...
Qisheng Hao, Qisheng Hao, Lichao Cha, Lichao Cha, Bin Zhou, Bin Zhou, Xinyu Li, Xinyu Li, Mingkai Gong, Qingze Li, Qingze Li, Guofei Dong, Mengqi Song, Zehua Wu, Zhongyi Guo, Fabo Qiu, Fabo Qiu, Xiaowei Wang, Lantian Tian, Lantian Tian   +19 more
doaj   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

DCM-Net: dual-encoder CNN-Mamba network with cross-branch fusion for robust medical image segmentation

BMC Medical Imaging
Background Medical image segmentation is a critical task for the early detection and diagnosis of various conditions, such as skin cancer, polyps, thyroid nodules, and pancreatic tumors.
Chukwuemeka Clinton Atabansi, Sheng Wang, Hui Li, Jing Nie, Lei Xiang, Cheng Zhang, Haijun Liu, Xichuan Zhou, Dewei Li   +8 more
doaj   +1 more source