Results 71 to 80 of about 21,347 (255)

Development of a High‐Throughput LC–MS/MS Method for Simultaneous Quantification of Four Therapeutic Monoclonal Antibodies in Human Serum: Application in Clinical Therapeutic Drug Monitoring

Biomedical Chromatography, Volume 40, Issue 3, March 2026.
ABSTRACT Monoclonal antibody (mAb) therapies have revolutionized cancer treatment, significantly improving patient outcomes. However, the pharmacokinetics (PK) and pharmacodynamics (PD) of mAbs exhibit considerable variability due to nonlinear kinetics and individual differences, highlighting the need for therapeutic drug monitoring (TDM).
Yuan Yao, Guang‐Yao Huang, Ting‐Ting Wu, Ting‐Fei Tan, Feng‐Mei Hu, Chao Huang, Shan Gao, An‐Ping Guo, Jun‐Ping Wang   +8 more
wiley   +1 more source

Effect of Four Commonly Used Dissolution Media Surfactants on Pancreatin Proteolytic Activity

AAPS PharmSciTech, 2017
Proteolytic enzymes are often used in dissolution testing of cross-linked gelatin capsules that do not conform to the dissolution specification. Their catalytic activity, however, can be affected when they are added to a dissolution media containing ...
M. Guncheva, Erika S. Stippler
semanticscholar   +1 more source

In Vitro Assessment of the Impact of Industrial Processes on the Gastrointestinal Digestion of Milk Protein Matrices Using the INFOGEST Protocol

Foods, 2020
The goal of this study was to determine the impact of industrial processes on the digestion of six milk protein matrices using the harmonized INFOGEST in vitro static digestion protocol.
Nathalie Atallah, Barbara Deracinois, Audrey Boulier, Alain Baniel, Delphine Jouan-Rimbaud Bouveresse, Rozenn Ravallec, Christophe Flahaut, Benoit Cudennec   +7 more
doaj   +1 more source

Composition, Techno‐Functional Properties, and Biological Potential of Velvet and African Yam Beans as Plant Protein Sources

Sustainable Food Proteins, Volume 4, Issue 1, March 2026.
Graphical Overview of Protein quality characterization of velvet and African yam beans. ABSTRACT The increasing demand for plant‐based foods has intensified research in alternative protein sources. This study assessed the chemical composition, functional properties, and biological qualities of velvet bean (VB) and African yam bean (AYB) flours to ...
Chiemeziem Adanma Obike, Paul Ndubuisi Anyiam, Chinedum Uche Emelike, Emmanuel Nnaemeka Uhuo, Solomon Fanyam Igbazenda   +4 more
wiley   +1 more source

Cellulase, Coca-Cola®, pancreatin and ursodeoxycholic acid in the dissolution of gastric bezoars: why not all together?

Revista Espanola de Enfermedades Digestivas, 2018
Two cases of a chemical dissolution of gastric phytobezoars are presented. The novel approach of that management is the pharmacological mixture than completely made disappear the bezoars in patients fated to surgery removal.
Antonio Cerezo Ruiz, J. L. Domínguez Jiménez, Antonio Uceda-Vaño   +2 more
semanticscholar   +1 more source

Antioxidant Potential of Mung Bean (Vigna radiata) Albumin Peptides Produced by Enzymatic Hydrolysis Analyzed by Biochemical and In Silico Methods

Foods, 2020
The objective of this study was to investigate the biochemical antioxidant potential of peptides derived from enzymatically hydrolyzed mung bean (Vigna radiata) albumins using an 2,2′-Azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical ...
Jennifer Kusumah, Luis M. Real Hernandez, Elvira Gonzalez de Mejia   +2 more
doaj   +1 more source

An in vitro assay for neural crest cell migration through the somites [PDF]

, 1986
Neural crest cells in the trunk of the avian embryo come into contact with the somites and neural tube during the course of their migration. However, the relationship between the somites and the early migratory routes followed by these cells is not yet ...
Bronner-Fraser, Marianne, Guillory, Georgia   +1 more
core  

Identification of ACE-inhibitory peptides from Phaseolus vulgaris after in vitro gastrointestinal digestion [PDF]

, 2015
The objective of this study was to identify the angiotensin I-converting enzyme (ACE)-inhibitory peptides released from thermally treated Phaseolus vulgaris (pinto) whole beans after in vitro gastrointestinal digestion. The degree of hydrolysis increased
Bellesia, Andrea, Conte, Angela, Martini, Serena, Tagliazucchi, Davide   +3 more
core   +1 more source

Neuroprotective Nanoplatform Integrating Antioxidant MXene Nanozymes and Ferroptosis Inhibitors for Targeted Therapy of Cerebral Ischemia‐Reperfusion Injury

Advanced Science, Volume 13, Issue 7, 3 February 2026.
Cerebral ischemia‐reperfusion injury (CIRI) is a key pathological process limiting the efficacy of stroke therapy. This study has developed an innovative, multifunctional, brain‐targeted nanoplatform (RFP) containing MXene nanoenzymes and ferroptosis inhibitors.
Lu Wang, Chao Hou, Shuo Li, Lizhi Yang, Yiqun Lin, Sen Wang, Xiaohua Jia, Hui Hui, Wen He, Wei Zhang   +9 more
wiley   +1 more source

THE BIOTECHNOLOGICAL ASPECTS OF WHEY PROTEINS HYDROLYSATE ANTIOXIDANT ACTIVITY INCREASING IN THE DIGESTION MODEL

Современная наука и инновации, 2022
In the modeling of digestion using the complex of pepsin and pancreatin on protein substrates (KSB80, ISB90, ISB95) the most antioxidant activity have demonstrated ISB95 in a minimal time (30 minutes), which allows using it as a functional additive for ...
Elena Vladimirovna Budkevich, Roman Olegovich Budkevich, Aleksey Alekseyevich Martak, Nikita Mikhaylovich Fedortsov, Anastasiya Igorevna Eryomina   +4 more
doaj