Results 51 to 60 of about 11,936 (226)

Whole‐Genome Sequencing Pilot of the Central Asian Genomic Diversity Project Reveals Distinct Histories, Adaptation, and Introgression

Advanced Science, EarlyView.
As a pilot phase of the Central Asian Genomic Diversity Project, whole‐genome sequencing of 166 individuals from 20 Central Asian and Afghan Hazara populations reveals fine‐scale substructure shaped by repeated trans‐Eurasian migration and admixture. Integrated analyses uncover post‐admixture adaptation, archaic introgression, and medically relevant ...
Mengge Wang, Shuhan Duan, Qiuxia Sun, Renkuan Tang, Lintao Luo, Jie Zhong, Zhaxylyk Sabitov, CAGDP Consortium†, Lan‐Hai Wei, Chao Liu, Maxat Zhabagin, Guanglin He   +11 more
wiley   +1 more source

Plant pangenomics, current practice and future direction

Agriculture Communications
A pangenome encompasses the complete genetic diversity of a species, by assembling a range of representative individuals from various populations. This review describes the advances in plant pangenomics, tracing its evolution since the initial plant ...
Haifei Hu, Jian Wang, Shuai Nie, Junliang Zhao, Jacqueline Batley, David Edwards   +5 more
doaj   +1 more source

Why prokaryotes have pangenomes [PDF]

Nature Microbiology, 2017
The existence of large amounts of within-species genome content variability is puzzling. Population genetics tells us that fitness effects of new variants—either deleterious, neutral or advantageous—combined with the long-term effective population size of the species determines the likelihood of a new variant being removed, spreading to fixation or ...
James O. McInerney, Alan McNally, Mary J. O'Connell   +2 more
openaire   +3 more sources

PG-SCUnK: measuring pangenome graph representativeness using single-copy and universal K-mers

BMC Bioinformatics
Background Pangenome graphs integrate multiple assemblies to represent non-redundant genetic diversity. However, current evaluations of pangenome graphs rely primarily on technical parameters (e.g., total length, number of nodes/edges, growth curves ...
Tristan Cumer, Sotiria Milia, Alexander S. Leonard, Hubert Pausch   +3 more
doaj   +1 more source

A Pan‐Methylome Framework for Population‐Scale Bacterial Epigenomics

Advanced Science, EarlyView.
A scalable quantitative framework unlocks population‐level comparative epigenomics in bacteria. By transforming site‐level data into standardized traits, this approach reconstructs methylation‐informed phylogenies and defines the core epigenome.
Bin Ma, Huimin Gong, Ran Zhuo, Zaixiao Rao, Yanxi Wan, Mingyang Wang, Zahra Zeinalzadeh, Yuan Gao, Aohan Guan, Xinrun Li, Wanting Chen, Xiliang Wang, Yun Wan, Sihua Zhang, Yuncai Xiao, Qi Huang, Paul R. Langford, Xiangru Wang, Rui Zhou, Rui Luo, Hongbo Zhou, Chengliang Zhu, Hui Jin   +22 more
wiley   +1 more source

Pangenomes of multiple species for the "Cluster efficient pangenome graph construction with nf-core/pangenome" manuscript. [PDF]

<p>Pangenomes of multiple species for the "Cluster efficient pangenome graph construction with nf-core/pangenome" manuscript.</p> <p>Each pangenome is represented in a FASTA format file.
Heumos, Simon
core   +1 more source

Phased genome assemblies and pangenome graphs of human populations of Japan and Saudi Arabia

Scientific Data
The selection of a reference sequence in genome analysis is critical, as it serves as the foundation for all downstream analyses. Recently, the pangenome graph has been proposed as a data model that incorporates haplotypes from multiple individuals. Here
Maxat Kulmanov, Saeideh Ashouri, Yang Liu, Marwa Abdelhakim, Ebtehal Alsolme, Masao Nagasaki, Yasuyuki Ohkawa, Yutaka Suzuki, Rund Tawfiq, Katsushi Tokunaga, Toshiaki Katayama, Malak S. Abedalthagafi, Robert Hoehndorf, Yosuke Kawai   +13 more
doaj   +1 more source

Rice Pangenome Research Progress: From Diversity Dissection to Breeding Applications

Guangdong nongye kexue
Rice is one of the world's most important staple crops. Traditional rice genomic research has long relied on a single reference genome (e.g., Nipponbare), which suffers from "reference bias" and fails to capture the full breadth of genetic diversity in ...
Haifei HU, Wenli TENG, Hai ZHOU, Junliang ZHAO, Jingbo ZHOU   +4 more
doaj   +1 more source

Adaptive Responses of Tropical Crops: A Multi‐Scale Omics Integrated Perspective

Advanced Science, EarlyView.
Tropical crops integrate genomic, morphological, physiological, and ecological adaptations to thrive under extreme and variable environments. This review highlights how natural selection, domestication, and breeding shape stress resilience, resource‐use strategies, and productivity in sugarcane, banana, cassava, rubber and oil palm, offering new routes
Peilin Wang, Chenhui Li, Dongjiao Wang, Qibin Wu, Zhen Zeng, Huiming Guo, Han Cheng, Songbi Chen, Hongxing Cao, Hongmei Cheng, Jianghui Xie, Youxiong Que   +11 more
wiley   +1 more source

Computational Intelligence Accelerates CRISPR‐Cas‐Based Diagnostic Design

iLABMED, EarlyView.
Computational intelligence, including pangenome‐guided target mining, machine‐learning‐based guide RNA optimization, and autonomous AI agents, is shifting CRISPR diagnostic design from empirical screening to systematic, data‐driven engineering and accelerating the path from pathogen discovery to deployable diagnostics.
Hengyu Wang, Qiurun He, Xuhu Mao, Yong Sheng   +3 more
wiley   +1 more source