Results 81 to 90 of about 11,936 (226)

Harnessing Natural Diversity and Rational Design for Enhanced Plant Immunity

Plant, Cell &Environment, EarlyView.
ABSTRACT Plant pathogens cause crop loss. Genetic resistance, through natural genetic diversity or engineered resistance, can be highly effective in protecting plants from infection. Genetic resistance from wild relatives of crops has been successfully introduced into crops to control pathogen infection.
Nathan Diplock, Jennifer D. Lewis
wiley   +1 more source

Cluster efficient pangenome graph construction with nf-core/pangenome

Bioinformatics
Abstract Motivation Pangenome graphs offer a comprehensive way of capturing genomic variability across multiple genomes. However, current construction methods often introduce biases, excluding complex sequences or relying on references. The PanGenome Graph Builder (PGGB) addresses these issues.
Simon Heumos, Michael L Heuer, Friederike Hanssen, Lukas Heumos, Andrea Guarracino, Peter Heringer, Philipp Ehmele, Pjotr Prins, Erik Garrison, Sven Nahnsen   +9 more
openaire   +4 more sources

Whole Genome Characterization of Klebsiella Strains in European Hedgehogs and Human Nosocomial Settings Identified Shared Sequence Types, Antimicrobial Resistance Genes and Plasmids

Zoonoses and Public Health, EarlyView.
ABSTRACT Introduction Klebsiella pneumoniae is a pathogen associated with healthcare‐acquired infections and antimicrobial resistance (AMR) to beta‐lactams and carbapenems. Although wild animals are not typically exposed to antibiotics, they can harbour resistant strains. The European hedgehog (Erinaceus europaeus) is increasingly found in urban areas,
Biel Garcias, Chiara Seminati, Carolin M. Kobras, Samuel K. Sheppard, Rafael A. Molina‐López, Laila Darwich   +5 more
wiley   +1 more source

Pangenome structures : design, construction, and applications [PDF]

The human {pangenome represents a set of genomic sequences of diverse humans. Any two sequences from this set are likely to be identical in large subsequences. Differences (so-called variations) predominantly involve just one or a few nucleotides.
Büchler, Thomas
core   +1 more source

Supplemental File 6. Pangenome Matchtable [PDF]

, 2020
The matchtable produced by the Pangenome pipeline for the NTM genomes. Gzipped for size. Supplemental File 6.
Thomas Clarke (8605536)
core   +1 more source

Molecular insights and translational opportunities to enhance heat tolerance in rice

The Plant Genome, Volume 19, Issue 3, September 2026.
Abstract Heat stress is an increasingly serious threat to rice (Oryza sativa L.) productivity, yet the genetic and regulatory architecture underlying thermotolerance remain poorly resolved and fragmented across studies. Earlier research focused on individual pathways or specific developmental stages; however, recent advances now support an integrated ...
Prabhat Rana, Chanderkant Chaudhary, Rajat Pruthi, Mansi Sharma, Bhupinderjeet Singh, Ravi Kiran Reddy Kondi, Mallesham Bulle, Prasanta K. Subudhi   +7 more
wiley   +1 more source

PharmVar GeneFocus: CYP1A2—Clinical Impact, Genetic Variation, and Updated Nomenclature

Clinical Pharmacology &Therapeutics, Volume 120, Issue 2, Page 313-323, August 2026.
The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the highly polymorphic human CYP1A2 gene. CYP1A2 plays a crucial role in the biotransformation of several commonly used drugs, including antipsychotics, antidepressants, anxiolytics, and methylxanthines.
Katalin Monostory, Gonzalo Villapalos Garcia, Dora Koller, Solomon Adams, Chad A. Bousman, Evangelia Eirini Tsermpini, Michelle Whirl‐Carrillo, Amy J. Turner, Volker M. Lauschke, Mohamed Nagy, Erin C. Boone, Teri E. Klein, Pablo Zubiaur, Andrea Gaedigk   +13 more
wiley   +1 more source

Roary (default settings): pangenome reference [PDF]

, 2019
Roary: pangenome reference of whole collection (n=13 ...
GlobalPneumoSeq Sanger (7427966)
core   +1 more source

A Draft Arab Pangenome Reference

, 2023
Abstract Human pangenomes provide a comprehensive portrayal of genetic diversity of humans, yet it lacks representation of Arab populations. We constructed the Arab Pangenome Reference (APR) from 43 individuals with diverse Arab ethnicities. Nuclear and mitochondrial pangenomes were constructed utilizing 35.52X High fidelity long reads and 53 ...
Nasna Nassir, Mohamed A. Almarri, Muhammad Kumail, Nesrin Mohamed, Bipin Balan, Shehzad Hanif, Maryam AlObathani, Bassam Jamalalail, Hanan Elsokary, Dasuki Kondaramage, Suhana Shiyas, Noor Kosaji, Dharana Satsangi, Madiha Hamdi Saif Abdelmotagali, Ahmad Abou Tayoun, Olfat Zuhair Salem Ahmed, Douaa Fathi Youssef, Hanan Al Suwaidi, Ammar Albanna, Stefan Du Plessis, Hamda Hassan Khansaheb, Alawi Alsheikh-Ali, Mohammed Uddin   +22 more
openaire   +1 more source

Benchmarking pangenome dynamics and horizontal gene transfer in Mycobacterium marinum evolution

Frontiers in Microbiology
Horizontal gene transfer (HGT) is a key driver of microbial evolution, promoting genetic diversity and contributing to the emergence of antibiotic resistance. This study explores the pangenome dynamics and HGT in Mycobacterium marinum (M.
Khandker Shahed, Sk Injamamul Islam, Papungkorn Sangsawad, Won-Kyo Jung, Patima Permpoonpattana, Nguyen Vu Linh   +5 more
doaj   +1 more source